PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
STAT1	1	KIT	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique	Deberry C (1997), Deberry C (1997), Deberry C (1997), Deberry C (1997), Chen TC (2014)	5
KIT	4	PIK3R1	6	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	De Sepulveda P (1999), van Dijk TB (2000), Serve H (1994), Zhu MJ (2007), Zhu MJ (2007), Yokouchi M (1997), Chen TC (2014)	7
PIK3CA	8	ARAF	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
DDX5	2	RPS20	1	biochemical	Havugimana PC (2012)	1
MYC	2	SQSTM1	0	affinity chromatography technology	Koch HB (2007)	1
EGFR	5	APPL1	1	unspecified method	Jones RB (2006)	1
KIT	4	PIK3R2	3	two hybrid	De Sepulveda P (1999)	1
NOTCH1	25	CBL	7	affinity chromatography technology, affinity chromatography technology	Jehn BM (2002), Platonova N (2015)	2
PIK3R2	3	PIK3CA	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Kuchay S (2013), Hein MY (2015)	3
RNF19B	0	PIK3CA	8	affinity chromatography technology	Huttlin EL (2017)	1
FASLG	0	PIK3R1	6	imaging technique	Chen TC (2014)	1
PIK3R1	6	IRS1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology	Hadari YR (1992), Morrison KB (2002), Gual P (2003), Hamer I (2002), Bazuine M (2003), Tzatsos A (2006), Calegari VC (2005), Tzatsos A (2009), Liu BA (2012), Sung CK (1994), Ren W (2013), Sung CK (1998), Grossmann A (2015), Grossmann A (2015), Antonetti DA (1996), Luo M (2007), Luo M (2007)	17
AKT1	1	ERBB3	3	affinity chromatography technology	Kim CK (2011)	1
IRS1	7	UBTF	8	affinity chromatography technology, affinity chromatography technology	Sun H (2003), Dalmizrak O (2007)	2
IRS4	2	PIK3CA	8	affinity chromatography technology	Sano H (2002)	1
PIK3R1	6	PIK3CA	8	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Woscholski R (1994), Chamberlain MD (2004), Ren SY (2005), Kamal M (2010), Sun M (2010), Hein MY (2015), Fang D (2001), Xiong Y (2009), Ivanov AA (2017)	9
BRAF	12	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SMAD3	1	IRS1	7	affinity chromatography technology	Brown KA (2008)	1
GSN	3	PIK3CA	8	affinity chromatography technology	Chellaiah MA (2001)	1
PTTG1	0	PIK3CA	8	affinity chromatography technology	Chamaon K (2005)	1
ESR1	0	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mo R (2006), Mo R (2006), Shi L (2011), Shi L (2011)	4
CDK9	3	ATR	6	affinity chromatography technology	Yu DS (2010)	1
NLGN3	3	PIK3CA	8	affinity chromatography technology	Huttlin EL (2017)	1
BRAF	12	YWHAH	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Huttlin EL (2017), Eisenhardt AE (2016)	3
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
PIK3CA	8	PDK1	1	protein complementation assay	Miao B (2010)	1
NTRK1	1	IRS2	6	affinity chromatography technology	Emdal KB (2015)	1
ERBB3	3	PIK3R2	3	affinity chromatography technology, unspecified method, affinity chromatography technology	Schulze WX (2006), Jones RB (2006), Li J (2013)	3
HDAC1	4	PIK3CA	8	affinity chromatography technology	Hein MY (2015)	1
HDAC1	4	ESR1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Kawai H (2003), Kawai H (2003), Varshochi R (2005), Varshochi R (2005), Kurtev V (2004), Liu XF (2004), Itoh Y (2007), Tarallo R (2011), Yoshimaru T (2013)	9
CSF1R	0	KIT	4	affinity chromatography technology, enzymatic study	Tsujimura T (1999), Tsujimura T (1999)	2
PCBP1	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NLGN3	3	PIK3R1	6	affinity chromatography technology	Huttlin EL (2017)	1
CBL	7	PIK3R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Lin H (2001), Hartley D (1995), Feshchenko EA (2004), Alcazar I (2009), Brehme M (2009), Brehme M (2009), Grossmann A (2015)	7
PIK3CA	8	SMAD3	1	pull down	Richard KC (2006)	1
HRAS	2	IL24	0	two hybrid	Arroyo R (2015)	1
CDK9	3	PDGFRA	3	genetic interference	Shen JP (2017)	1
PIK3CA	8	CYTH3	1	protein complementation assay	Miao B (2010)	1
ESR1	0	PIK3R2	3	affinity chromatography technology	Cabodi S (2004)	1
CDK9	3	CHEK1	2	genetic interference	Shen JP (2017)	1
PIK3R2	3	SQSTM1	0	affinity chromatography technology	Sung CK (1998)	1
HAVCR2	0	PIK3R3	0	affinity chromatography technology	Huttlin EL (2017)	1
IRS4	2	PIK3R3	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
NTRK1	1	STAT1	1	affinity chromatography technology	Emdal KB (2015)	1
NEDD4L	3	BRAF	12	enzymatic study	Persaud A (2009)	1
CSF1R	0	GRB2	2	two hybrid, pull down, affinity chromatography technology	Mancini A (1997), Mancini A (1997), Wang Y (1999)	3
TMEM52B	0	PIK3CA	8	affinity chromatography technology	Huttlin EL (2017)	1
LCK	0	PIK3R1	6	pull down	Kapeller R (1994)	1
MYC	2	PDK1	1	genetic interference	Toyoshima M (2012)	1
PIK3CA	8	ITIH1	2	two hybrid	Wang J (2008)	1
RNF19B	0	PIK3R1	6	affinity chromatography technology	Huttlin EL (2017)	1
BRAF	12	EGFR	5	genetic interference	Shen JP (2017)	1
PCBP1	2	PIK3CA	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	PCBP1	2	affinity chromatography technology	Emdal KB (2015)	1
SUN2	1	PIK3CA	8	affinity chromatography technology	Huttlin EL (2017)	1
CD40	3	SGK1	4	affinity chromatography technology	Ewing RM (2007)	1
DERL1	2	DDX5	2	affinity chromatography technology	You H (2017)	1
HAVCR2	0	PIK3CA	8	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	PIK3R1	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Saleem A (1995), Saleem A (1995), Wang J (1995), Wang J (1995), Wang J (1995), Bandyopadhyay S (2010), Takahashi Y (1999), Gelkop S (2001), Jain SK (1997), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Cerboni C (1998), Bisson N (2011), Bisson N (2011), Weinger JG (2008), Weinger JG (2008), Weinger JG (2008)	18
PDGFRA	3	PIK3CA	8	affinity chromatography technology, enzymatic study	Valius M (1993), Valius M (1993)	2
NTRK1	1	PIK3R2	3	affinity chromatography technology	Emdal KB (2015)	1
AKT1	1	ESR1	0	enzymatic study	Campbell RA (2001)	1
HAVCR2	0	PIK3R1	6	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Xiong Y (2009), Xiong Y (2009), Ivanov AA (2017)	3
NTRK1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takahashi Y (2011), Emdal KB (2015), Emdal KB (2015)	3
PDGFRA	3	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PIK3CA	8	IL24	0	two hybrid	Arroyo R (2015)	1
PIK3CA	8	DGKZ	6	enzymatic study, affinity chromatography technology	Luo B (2003), Luo B (2003)	2
IRS4	2	PIK3R2	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
IRS2	6	GRB2	2	unspecified method, affinity chromatography technology	Liu BA (2012), Bisson N (2011)	2
EFNB2	0	PIK3R1	6	affinity chromatography technology	Huttlin EL (2015)	1
SQSTM1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanji K (2012), Yan J (2013), Yan J (2013), Chen Q (2015)	4
IRS2	6	UBTF	8	affinity chromatography technology	Sun H (2003)	1
EGFR	5	PIK3R2	3	affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, protein complementation assay	Tong J (2009), Jones RB (2006), Foerster S (2013), Kotlyar M (2015), Gout I (1992), Petschnigg J (2014)	6
AKT1	1	IL13RA2	0	two hybrid	Arroyo R (2015)	1
SGK1	4	HRAS	2	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
PDGFRA	3	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AKT1	1	THRSP	0	two hybrid	Arroyo R (2015)	1
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
APPL1	1	PIK3R2	3	two hybrid	Grossmann A (2015)	1
EGFR	5	IRS1	7	unspecified method	Jones RB (2006)	1
STK11	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HRAS	2	CBL	7	affinity chromatography technology	Lito P (2008)	1
ERBB3	3	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Verma N (2017), Verma N (2017)	2
DERL1	2	IRS4	2	affinity chromatography technology	You H (2017)	1
EGFR	5	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, imaging technique	Tong J (2009), Wen G (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Chen TC (2014)	6
DERL1	2	EGFR	5	affinity chromatography technology, affinity chromatography technology	Dong QZ (2013), Dong QZ (2013)	2
TNFRSF1A	3	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PTTG1	0	PIK3R1	6	affinity chromatography technology	Chamaon K (2005)	1
HRAS	2	BRAF	12	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Stang S (1997), Reuter CW (1995), Huttlin EL (2017), Eisenhardt AE (2016), Ivanov AA (2017)	5
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
YWHAH	0	IRS2	6	affinity chromatography technology	Hein MY (2015)	1
FASLG	0	GRB2	2	affinity chromatography technology, pull down, pull down	Ghadimi MP (2002), Ghadimi MP (2002), Wenzel J (2001)	3
IRS1	7	PIK3R3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Xia X (1999), Mothe I (1997), Grossmann A (2015), Grossmann A (2015)	4
GLIS2	2	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK9	3	SMAD3	1	enzymatic study	Alarcon C (2009)	1
ATR	6	ARHGEF1	5	unspecified method	Kim ST (1999)	1
FLRT1	4	PIK3CA	8	affinity chromatography technology	Huttlin EL (2017)	1
ARAF	0	KRAS	1	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Rolland T (2014), So J (2015), Ivanov AA (2017)	3
RASD2	1	GNB1	4	two hybrid	Hill C (2009)	1
KRAS	1	THRSP	0	two hybrid	Arroyo R (2015)	1
HDAC1	4	UBTF	8	imaging technique, affinity chromatography technology, biochemical	Ali SA (2012), Ali SA (2012), Ali SA (2012)	3
PDGFRA	3	CRK	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Yokote K (1998), Matsumoto T (2000), Matsumoto T (2000), Chen TC (2014)	4
KRAS	1	GRB2	2	genetic interference	Hart T (2015)	1
ERBB3	3	CRK	0	unspecified method	Jones RB (2006)	1
ZDHHC1	2	PIK3CA	8	affinity chromatography technology	Huttlin EL (2017)	1
LCK	0	PIK3CA	8	affinity chromatography technology, pull down	Sade H (2004), Prasad KV (1993)	2
MYC	2	DNAJB6	3	affinity chromatography technology	Koch HB (2007)	1
TMEM52B	0	PIK3R2	3	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	SUN2	1	affinity chromatography technology	Emdal KB (2015)	1
STK11	2	THRSP	0	two hybrid	Arroyo R (2015)	1
LCK	0	SQSTM1	0	pull down	Joung I (1996)	1
ARAF	0	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGFR	5	TNFRSF1A	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ARAF	0	GLIS2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ESR1	0	MYC	2	affinity chromatography technology	Cheng AS (2006)	1
EGFR	5	HDAC1	4	affinity chromatography technology	Yao Z (2017)	1
NLGN3	3	PIK3R3	0	affinity chromatography technology	Huttlin EL (2017)	1
RASD2	1	PIK3R1	6	affinity chromatography technology, pull down	Bang S (2012), Bang S (2012)	2
PIK3CA	8	STAT1	1	enzymatic study	Nguyen H (2001)	1
NEDD9	3	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Minegishi M (1996), Ohashi Y (1998), Ohashi Y (1998), Ohashi Y (1998), Kanda H (1997)	5
SQSTM1	0	PIK3R1	6	far western blotting, affinity chromatography technology	Sung CK (1998), Sung CK (1998)	2
CRK	0	PIK3R3	0	affinity chromatography technology, two hybrid	Brehme M (2009), Grossmann A (2015)	2
LCK	0	NOTCH1	25	affinity chromatography technology, affinity chromatography technology	Sade H (2004), Sade H (2004)	2
GLIS2	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
WDR5	2	DPY30	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mak AB (2010), Bailey JK (2015), Hauri S (2016)	3
KRAS	1	UBTF	8	genetic interference	Luo J (2009)	1
NTRK1	1	DDX5	2	affinity chromatography technology	Emdal KB (2015)	1
CD28	0	PIK3R2	3	affinity chromatography technology	Alcazar I (2009)	1
IRS4	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
PIK3CA	8	SGK1	4	pull down	Park J (1999)	1
NTRK1	1	DNAJB6	3	affinity chromatography technology	Emdal KB (2015)	1
PIK3CA	8	AMBP	1	two hybrid	Wang J (2008)	1
SMAD3	1	HDAC1	4	two hybrid, pull down	Liberati NT (2001), Akiyoshi S (1999)	2
CHEK1	2	PIK3CA	8	genetic interference	Shen JP (2017)	1
ESR1	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Castoria G (2001), Simoncini T (2000), Simoncini T (2000)	3
EGFR	5	HDAC6	0	affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Gao YS (2010), Deribe YL (2009), Deribe YL (2009), Deribe YL (2009), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	7
GNB1	4	GNAQ	1	biochemical	Wan C (2015)	1
NTRK1	1	GNB1	4	affinity chromatography technology	Emdal KB (2015)	1
CD40	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	Ha YJ (2011), Ha YJ (2011)	2
PIK3CA	8	SQSTM1	0	two hybrid	Wang J (2008)	1
IRS4	2	YWHAH	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
KIT	4	GRB2	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down	De Sepulveda P (1999), Thoemmes K (1999), Feng GS (1996), Sun J (2007), Zhu MJ (2007), Wollberg P (2003), Brizzi MF (1996)	7
DEFA5	1	PIK3CA	8	affinity chromatography technology	Huttlin EL (2017)	1
ARAF	0	PIK3R1	6	pull down	Fang Y (2002)	1
HDAC1	4	STAT1	1	affinity chromatography technology	Kraemer OH (2006)	1
GNB1	4	PIK3CA	8	affinity chromatography technology	Xiong Y (2009)	1
IRS2	6	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Argetsinger LS (1996), Verdier F (1997), Kim B (1998), Hamer I (2002), Calegari VC (2005), Tzatsos A (2009), Ren W (2013), Hein MY (2015)	8
BRAF	12	PIK3CA	8	genetic interference	Shen JP (2017)	1
RNF19B	0	PIK3R2	3	affinity chromatography technology	Huttlin EL (2017)	1
TNFSF13	0	TNFRSF1A	3	pull down	Kelly K (2000)	1
PIK3R1	6	HRAS	2	affinity chromatography technology, pull down, imaging technique	Hanna AN (1999), Rodriguez-Viciana P (1997), Chen TC (2014)	3
ESR1	0	IRS1	7	affinity chromatography technology, affinity chromatography technology	Morelli C (2003), Morelli C (2003)	2
ATR	6	PIK3CA	8	unspecified method	Kim ST (1999)	1
CBL	7	CSF1R	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mancini A (2002), Mancini A (2002), Mancini A (2002), Wilhelmsen K (2002), Wilhelmsen K (2002), Wang Y (1999), Wang Y (1999), Tanaka S (1995), Ota J (2000), Ota J (2000)	10
APPL1	1	PIK3R1	6	affinity chromatography technology, two hybrid	Yang L (2003), Grossmann A (2015)	2
KIT	4	CRK	0	two hybrid	Yokouchi M (1997)	1
NTRK1	1	ARHGEF1	5	affinity chromatography technology	Emdal KB (2015)	1
KRAS	1	PIK3R2	3	two hybrid	Wang J (2011)	1
FLRT1	4	PIK3R2	3	affinity chromatography technology	Huttlin EL (2017)	1
KRAS	1	TNFSF13	0	two hybrid	Arroyo R (2015)	1
PIK3CA	8	ATPIF1	0	two hybrid	Wang J (2008)	1
EGFR	5	PIK3R3	0	unspecified method, two hybrid, imaging technique, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014)	4
FLRT1	4	PIK3R1	6	affinity chromatography technology	Huttlin EL (2017)	1
MYC	2	IRS2	6	genetic interference	Toyoshima M (2012)	1
PIK3CA	8	UFD1	1	two hybrid	Wang J (2008)	1
MYC	2	SMAD2	5	affinity chromatography technology, pull down, two hybrid, fluorescent resonance energy transfe	Feng XH (2002), Feng XH (2002), Feng XH (2002), Ivanov AA (2017)	4
FLRT1	4	PIK3R3	0	affinity chromatography technology	Huttlin EL (2017)	1
CD28	0	PIK3CA	8	affinity chromatography technology	Slavik JM (1999)	1
CBL	7	IRS1	7	affinity chromatography technology	Ahmed Z (2000)	1
DNAJB6	3	HDAC6	0	affinity chromatography technology, affinity chromatography technology	Hageman J (2010), Hageman J (2010)	2
EGFR	5	DDX5	2	affinity chromatography technology	Yao Z (2017)	1
IRS1	7	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Skolnik EY (1993), Skolnik EY (1993), Skolnik EY (1993), Morrison KB (2002), Giorgetti-Peraldi S (1995), Liu BA (2012), Bisson N (2011)	7
NEDD4L	3	NTRK1	1	enzymatic study	Persaud A (2009)	1
MYC	2	NTRK1	1	genetic interference	Toyoshima M (2012)	1
GNAQ	1	PIK3R1	6	affinity chromatography technology	Ballou LM (2003)	1
NTRK1	1	APPL1	1	affinity chromatography technology	Emdal KB (2015)	1
GLIS2	2	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PDGFRA	3	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAH	0	IRS1	7	affinity chromatography technology	Ichimura T (2002)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
PDGFRA	3	KIT	4	affinity chromatography technology	Zhu MJ (2007)	1
LCK	0	SMAD2	5	pull down	Richard KC (2006)	1
GLIS2	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARAF	0	DDX5	2	affinity chromatography technology	So J (2015)	1
GRB2	2	CD28	0	pull down, pull down	Okkenhaug K (1998), Nunes JA (1996)	2
PIK3CA	8	TNFSF13	0	two hybrid	Arroyo R (2015)	1
CD40	3	CBL	7	affinity chromatography technology	Deregibus MC (2003)	1
GRB2	2	AMBP	1	two hybrid	Wang J (2008)	1
BRAF	12	KRAS	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Huttlin EL (2017), Eisenhardt AE (2016), Ivanov AA (2017)	3
HDAC1	4	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Xu Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	5
GNB1	4	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	Xiong Y (2009), Xiong Y (2009)	2
AKT1	1	CHEK1	2	genetic interference	Shen JP (2017)	1
PIK3CA	8	THRSP	0	two hybrid	Arroyo R (2015)	1
TNFRSF1A	3	STAT1	1	affinity chromatography technology	Wang Y (2000)	1
EIPR1	1	PIK3CA	8	genetic interference	Blomen VA (2015)	1
PIK3R3	0	PIK3R1	6	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	PIK3R1	6	affinity chromatography technology	Emdal KB (2015)	1
ESR1	0	GNB1	4	affinity chromatography technology, affinity chromatography technology	Tarallo R (2011), Han SJ (2016)	2
PDGFRA	3	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	CDK9	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kanazawa S (2003), Bres V (2009), Eberhardy SR (2001), Gargano B (2007), Jaenicke LA (2016)	5
NEDD9	3	SMAD3	1	two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Feng L (2004), Nourry C (2004), Feng L (2004), Feng L (2004), Liu X (2000), Liu X (2000)	6
EGFR	5	PDK1	1	affinity chromatography technology	Tong J (2014)	1
IL20RA	2	PIK3R1	6	affinity chromatography technology	Huttlin EL (2017)	1
PIK3CA	8	RRM2	2	genetic interference	Shen JP (2017)	1
CCND2	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGFR	5	UMPS	4	affinity chromatography technology	Tong J (2014)	1
MYC	2	IRS4	2	affinity chromatography technology	Koch HB (2007)	1
IRS4	2	EGFR	5	unspecified method, affinity chromatography technology	Jones RB (2006), Tong J (2014)	2
EGFR	5	CRK	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Schulze WX (2006), Hashimoto Y (1998), Hashimoto Y (1998), Katayama H (1999), Ota S (1998), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	9
HAVCR2	0	PIK3R2	3	affinity chromatography technology	Huttlin EL (2017)	1
ESR1	0	PSMC3IP	0	two hybrid	Arroyo R (2015)	1
DERL1	2	PIK3CA	8	affinity chromatography technology, affinity chromatography technology	Dong Q (2017), Dong Q (2017)	2
SQSTM1	0	NOTCH1	25	affinity chromatography technology, affinity chromatography technology	Ahn JS (2016), Ahn JS (2016)	2
APPL1	1	CBL	7	two hybrid	Grossmann A (2015)	1
PIK3CA	8	RPS20	1	two hybrid	Wang J (2008)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
FASLG	0	CRK	0	unspecified method	Voss M (2009)	1
SMAD3	1	NOTCH1	25	pull down, affinity chromatography technology	Blokzijl A (2003), Blokzijl A (2003)	2
GNAQ	1	PIK3CA	8	affinity chromatography technology	Ballou LM (2003)	1
NOTCH1	25	PIK3CA	8	affinity chromatography technology	Sade H (2004)	1
IRS4	2	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fantin VR (1998), Bisson N (2011), Bisson N (2011)	3
CRK	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	Gelkop S (2001), Gelkop S (2001), Garcia-Guzman M (2000), Brehme M (2009), Grossmann A (2015), Chen TC (2014)	6
PIK3CA	8	TSPAN14	1	affinity chromatography technology	Hein MY (2015)	1
ARHGEF1	5	PIK3CA	8	affinity chromatography technology, affinity chromatography technology	Holinstat M (2003), Holinstat M (2003)	2
LCK	0	CBL	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Rao N (2002), Tsygankov AY (1996), Reedquist KA (1996), Nervi S (2005)	4
FASLG	0	LCK	0	pull down	Wenzel J (2001)	1
CRK	0	PTTG1	0	two hybrid	Grossmann A (2015)	1
PIK3R2	3	PIK3R3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
SMAD2	5	AKT1	1	affinity chromatography technology	Song K (2006)	1
IRS1	7	IRS2	6	biochemical	Sun H (2003)	1
SMAD2	5	NEDD9	3	affinity chromatography technology	Liu X (2000)	1
SMAD3	1	DDX5	2	pull down	Gao S (2009)	1
CRK	0	PIK3CA	8	affinity chromatography technology	Brehme M (2009)	1
EFNB2	0	PIK3R3	0	affinity chromatography technology	Huttlin EL (2015)	1
ESR1	0	DNAJB6	3	affinity chromatography technology	Dhamad AE (2016)	1
TNFRSF1A	3	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
STAT1	1	PDGFRA	3	imaging technique	Chen TC (2014)	1
YWHAH	0	ARAF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ichimura T (2002), So J (2015), Hein MY (2015)	3
NTRK1	1	YWHAH	0	affinity chromatography technology	Emdal KB (2015)	1
PIK3R3	0	PIK3CA	8	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Mothe I (1997), Grossmann A (2015), Hein MY (2015), Huttlin EL (2017)	4
ERBB3	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Crovello CS (1998), Li J (2013)	3
BRAF	12	ARAF	0	affinity chromatography technology, imaging technique, affinity chromatography technology, fluorescent resonance energy transfe	Gloeckner CJ (2007), Chen TC (2014), Huttlin EL (2017), Ivanov AA (2017)	4
PIK3R3	0	AMBP	1	two hybrid	Wang J (2008)	1
PIK3CA	8	GLIS2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PIK3CA	8	SMAD2	5	pull down	Richard KC (2006)	1
ARAF	0	HRAS	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LCK	0	SMAD3	1	pull down	Richard KC (2006)	1
DGKZ	6	HRAS	2	affinity chromatography technology	Topham MK (2001)	1
CBL	7	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015)	61
PIK3CA	8	HRAS	2	pull down, two hybrid, pull down	Vargiu P (2004), Li W (2000), Rodriguez-Viciana P (1996)	3
MANSC1	4	PIK3R2	3	affinity chromatography technology	Huttlin EL (2017)	1
PIK3CA	8	BEX2	0	two hybrid	Arroyo R (2015)	1
CBL	7	PDGFRA	3	affinity chromatography technology, pull down	Bonita DP (1997), Bonita DP (1997)	2
TMEM52B	0	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SQSTM1	0	NTRK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wooten MW (2001), Geetha T (2003), Jadhav T (2008), Wooten MW (2008), Wooten MW (2008), Zheng C (2015)	6
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
CSF1R	0	PIK3R1	6	affinity chromatography technology, imaging technique	Wang Y (1999), Chen TC (2014)	2
ARAF	0	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HDAC1	4	DDX5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wilson BJ (2004), Wilson BJ (2004), Guo J (2010), Jacobs AM (2007), Mooney SM (2010), Mooney SM (2010)	6
PIK3CA	8	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sattler M (1997), Sattler M (1997), Chernock RD (2001), Chernock RD (2001), Brehme M (2009)	5
PIK3CA	8	DPY30	1	affinity chromatography technology	Hein MY (2015)	1
KRAS	1	EFNB2	0	genetic interference	Luo J (2009)	1
APPL1	1	AKT1	1	affinity chromatography technology, two hybrid, imaging technique	Yang L (2003), Grossmann A (2015), Chen TC (2014)	3
SMAD2	5	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Wotton D (1999), Takeda M (2004), Lo RS (2001)	4
KIT	4	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zeng S (2005), Brizzi MF (1996), Dong Y (2015)	3
ESR1	0	UBTF	8	affinity chromatography technology	Tarallo R (2011)	1
NTRK1	1	WDR5	2	affinity chromatography technology	Emdal KB (2015)	1
MANSC1	4	PIK3CA	8	affinity chromatography technology	Huttlin EL (2017)	1
PIK3CA	8	UMPS	4	two hybrid	Arroyo R (2015)	1
IRS1	7	PIK3CA	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tzatsos A (2006), Bazuine M (2003), Whiteman EL (2003), Kuchay S (2013)	4
NTRK1	1	HDAC6	0	affinity chromatography technology	Emdal KB (2015)	1
PDGFRA	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, imaging technique	Zhu MJ (2007), Zhu MJ (2007), Chen TC (2014)	3
NEDD4L	3	PIK3CA	8	enzymatic study	Wang Z (2016)	1
TNFRSF1A	3	PIK3R1	6	affinity chromatography technology	Pincheira R (2008)	1
IL13RA2	0	CHEK1	2	affinity chromatography technology	Huttlin EL (2017)	1
HDAC1	4	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuoka Y (2008), Matsuoka Y (2008), Liu T (2007), Liu T (2007), Liu T (2007), Koch HB (2007), Hwang IY (2012), Hein MY (2015)	8
ARHGEF1	5	HRAS	2	enzymatic study	Kuiperij HB (2003)	1
NEDD9	3	LCK	0	affinity chromatography technology	Minegishi M (1996)	1
TNFRSF1A	3	CBL	7	affinity chromatography technology	Narita T (2005)	1
CDK9	3	PIK3CA	8	genetic interference	Shen JP (2017)	1
ESR1	0	GSN	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ambrosino C (2010), Ambrosino C (2010), Tarallo R (2011)	3
EGFR	5	PDGFRA	3	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
CDK9	3	DDX5	2	affinity chromatography technology	Jeronimo C (2007)	1
GRB2	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Hildt E (1999), Kurada BR (2009)	2
EFNB2	0	PIK3CA	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PDK1	1	SGK1	4	enzymatic study	Seong HA (2007)	1
YWHAH	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Subramanian RR (2001), Taipale M (2014), Taipale M (2014)	3
SMAD3	1	SQSTM1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
PIK3R2	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
EGFR	5	ATR	6	affinity chromatography technology	Foerster S (2013)	1
ERBB3	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hellyer NJ (2001), Lin J (1999), Crovello CS (1998), Graus-Porta D (1997), Jones RB (2006), Li J (2013), Servidei T (2008), Servidei T (2008), Ritch PS (2005), Tang X (2002)	10
PIK3CA	8	RAC1	7	affinity chromatography technology	Eller-Borges R (2015)	1
PDGFRA	3	RRM2	2	genetic interference	Shen JP (2017)	1
ARAF	0	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
KRAS	1	EGFR	5	genetic interference	Hart T (2015)	1
EGFR	5	RPS20	1	affinity chromatography technology	Yao Z (2017)	1
ESR1	0	RPS20	1	affinity chromatography technology	Tarallo R (2011)	1
AKT1	1	GNB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klein JB (2005), Xiong Y (2009), Xiong Y (2009)	3
IRS2	6	PIK3CA	8	affinity chromatography technology, affinity chromatography technology	Whiteman EL (2003), Fukushima T (2015)	2
RPS20	1	SUN2	1	two hybrid	Wang J (2011)	1
NTRK1	1	PDGFRA	3	affinity chromatography technology	Emdal KB (2015)	1
MYC	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGFR	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hitosugi T (2007), Hitosugi T (2007), Yao Z (2017)	3
CCND2	2	GSN	3	affinity chromatography technology	Russo LC (2017)	1
PIK3CA	8	CYTH2	2	protein complementation assay	Miao B (2010)	1
CYTH2	2	GNAQ	1	affinity chromatography technology, pull down	Giguere P (2006), Giguere P (2006)	2
NTRK1	1	PIK3CA	8	affinity chromatography technology	Emdal KB (2015)	1
AKT1	1	DDX5	2	affinity chromatography technology, affinity chromatography technology	Zhu QS (2011), Zhu QS (2011)	2
NEDD4L	3	NOTCH1	25	affinity chromatography technology	Puca L (2013)	1
MYC	2	PCBP1	2	affinity chromatography technology	Koch HB (2007)	1
PIK3R1	6	CD28	0	unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pages F (1996), Pages F (1996), Alcazar I (2009), Fang D (2001)	4
ARAF	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TNFRSF1A	3	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PIK3CA	8	RASGRP3	3	enzymatic study	Brodie C (2004)	1
CBL	7	SMAD3	1	affinity chromatography technology, affinity chromatography technology	Kang JM (2012), Kang JM (2012)	2
MYC	2	SMAD3	1	affinity chromatography technology, pull down, two hybrid	Feng XH (2002), Feng XH (2002), Feng XH (2002)	3
TNFRSF1A	3	PIK3CA	8	affinity chromatography technology	Narita T (2005)	1
APPL1	1	HDAC1	4	affinity chromatography technology, pull down, imaging technique	Banach-Orlowska M (2009), Banach-Orlowska M (2009), Chen TC (2014)	3
ESR1	0	IRS2	6	affinity chromatography technology, affinity chromatography technology	Morelli C (2003), Morelli C (2003)	2
TMEM52B	0	PIK3R3	0	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	IL24	0	two hybrid	Arroyo R (2015)	1
IRS1	7	PIK3R2	3	affinity chromatography technology	Kuchay S (2013)	1
AKT1	1	BRAF	12	affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique, fluorescent resonance energy transfe	Guan KL (2000), Guan KL (2000), Guan KL (2000), Chen TC (2014), Ivanov AA (2017)	5
CD40	3	PIK3CA	8	affinity chromatography technology	Deregibus MC (2003)	1
ADAP1	3	PIK3CA	8	pull down, enzymatic study	Zemlickova E (2003), Zemlickova E (2003)	2
IRS2	6	PIK3R3	0	affinity chromatography technology, affinity chromatography technology	Xia X (1999), Huttlin EL (2017)	2
ATR	6	CHEK1	2	unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, genetic interference	Kim ST (1999), Sun TP (2009), Zhao H (2001), Rocha S (2005), Choi JH (2007), Ha K (2011), Srivas R (2016)	7
TNFRSF1A	3	ATR	6	affinity chromatography technology	Huttlin EL (2017)	1
SGK1	4	NEDD4L	3	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Nagaki K (2006), Heise CJ (2010), Wiemuth D (2010), Xu BE (2005), Lamothe S (2013), Gao S (2009)	6
DEFA5	1	PIK3R1	6	affinity chromatography technology	Huttlin EL (2017)	1
KRAS	1	PIK3CA	8	two hybrid, genetic interference	Li W (2000), Hart T (2015)	2
ERBB3	3	PIK3R3	0	unspecified method, affinity chromatography technology	Jones RB (2006), Li J (2013)	2
PIK3CA	8	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CSF1R	0	PIK3R2	3	pull down	Gout I (1992)	1
PIK3CA	8	RASD2	1	pull down	Vargiu P (2004)	1
IRS1	7	AKT1	1	affinity chromatography technology, enzymatic study	Paz K (1999), Luo M (2007)	2
GRB2	2	PIK3R2	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
PIK3CA	8	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ESR1	0	PIK3CA	8	affinity chromatography technology, affinity chromatography technology	Simoncini T (2000), Yoshimaru T (2013)	2
PIK3CA	8	PSMC3IP	0	two hybrid	Arroyo R (2015)	1
BRAF	12	DNAJB6	3	affinity chromatography technology	Eisenhardt AE (2016)	1
NTRK1	1	UBTF	8	affinity chromatography technology	Emdal KB (2015)	1
GRB2	2	FTL	0	two hybrid	Wang J (2008)	1
PDGFRA	3	GRB2	2	affinity chromatography technology, affinity chromatography technology	Bazenet CE (1996), Severe N (2011)	2
NTRK1	1	RRM2	2	affinity chromatography technology	Emdal KB (2015)	1
PIK3CA	8	BEX1	0	two hybrid	Arroyo R (2015)	1
ESR1	0	DDX5	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ambrosino C (2010), Ambrosino C (2010), Fujita T (2003), Mooney SM (2010), Tarallo R (2011), Mooney SM (2010)	6
PIK3CA	8	EGFR	5	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LCK	0	KIT	4	affinity chromatography technology	Krystal GW (1998)	1
WDR5	2	PIK3CA	8	affinity chromatography technology	Gan Q (2011)	1
ATR	6	HDAC1	4	affinity chromatography technology	Schmidt DR (1999)	1
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
EGFR	5	IRS2	6	affinity chromatography technology	Tong J (2008)	1
PIK3CA	8	AKT1	1	affinity chromatography technology, protein complementation assay, affinity chromatography technology, enzymatic study	Mitra S (2011), Miao B (2010), Xiong Y (2009), Akil H (2015)	4
CSF1R	0	PIK3CA	8	pull down, two hybrid	Mancini A (1997), Mancini A (1997)	2
MYC	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PIK3CA	8	NEDD9	3	two hybrid	Wang J (2008)	1
FASLG	0	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Legler DF (2003)	2
AKT1	1	RAC1	7	enzymatic study	Kwon T (2000)	1
EFNB2	0	PIK3R2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NOTCH1	25	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Yatim A (2012)	2
KRAS	1	IL24	0	two hybrid	Arroyo R (2015)	1
CRK	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, two hybrid	Gesbert F (1998), Husson H (1997), Ingham RJ (1996), Ingham RJ (1996), Delehanty LL (2003), Garcia-Guzman M (2000), Garcia-Guzman M (2000), Barber DL (1997), Buday L (1996), Sawasdikosol S (1996), Sawasdikosol S (1996), Thien CB (1997), van Leeuwen JE (1999), Ribon V (1996), Lottin-Divoux S (2006), Reedquist KA (1996), Brehme M (2009), Brehme M (2009), Ota S (1998), Peterson ME (2008), Liu BA (2012), Fukazawa T (1996), Umehara H (2002), Grossmann A (2015)	24
IL20RA	2	PIK3CA	8	affinity chromatography technology	Huttlin EL (2017)	1
UBTF	8	PIK3CA	8	affinity chromatography technology	Dalmizrak O (2007)	1
CRK	0	IRS4	2	affinity chromatography technology, pull down	Karas M (2001), Koval AP (1998)	2
GRB2	2	RPS20	1	affinity chromatography technology	Brehme M (2009)	1
YWHAH	0	PIK3CA	8	affinity chromatography technology	Ichimura T (2002)	1
APPL1	1	PIK3CA	8	imaging technique	Chen TC (2014)	1
PIK3CA	8	DNAJB6	3	two hybrid	Wang J (2008)	1
CRK	0	DDX5	2	affinity chromatography technology	Brehme M (2009)	1
PIK3CA	8	FTL	0	two hybrid	Wang J (2008)	1
SMAD2	5	NEDD4L	3	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Gao S (2009), Colland F (2004), Gao S (2009), Yan X (2016)	4
PIK3CA	8	VARS2	0	two hybrid	Wang J (2008)	1
CYTH3	1	GNAQ	1	affinity chromatography technology	Laroche G (2007)	1
PIK3CA	8	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GRB2	2	PIK3R3	0	affinity chromatography technology	Bisson N (2011)	1
GRB2	2	PIK3CA	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Bisson N (2011), Huttlin EL (2017)	3
RASD2	1	AKT1	1	affinity chromatography technology	Bang S (2012)	1
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
PIK3CA	8	DDX5	2	two hybrid	Wang J (2008)	1
WDR5	2	MYC	2	affinity chromatography technology	Carugo A (2016)	1
HAVCR2	0	LCK	0	affinity chromatography technology	Rangachari M (2012)	1
CDK9	3	SMAD2	5	enzymatic study	Alarcon C (2009)	1
EGFR	5	STAT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Olayioye MA (1999), Xia L (2002), Andl CD (2004), Foerster S (2013), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	8
SMAD3	1	AKT1	1	affinity chromatography technology, imaging technique	Song K (2006), Chen TC (2014)	2
PIK3CA	8	IL13RA2	0	two hybrid	Arroyo R (2015)	1
CDK9	3	SQSTM1	0	biochemical	Garcia-Martinez LF (1997)	1
FASLG	0	PIK3CA	8	unspecified method	Voss M (2009)	1
ESR1	0	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Matsuda T (2001), Ito I (2010), Ito I (2010), Ito I (2010)	4
NEDD4L	3	YWHAH	0	affinity chromatography technology	Nagaki K (2006)	1
GRB2	2	YWHAH	0	affinity chromatography technology	Bisson N (2011)	1
SMAD3	1	ESR1	0	affinity chromatography technology	Ito I (2010)	1
CBL	7	PIK3R3	0	two hybrid, two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015), Grossmann A (2015)	3
PIK3R2	3	CRK	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Brehme M (2009), Brehme M (2009), Grossmann A (2015)	3
KIT	4	PIK3CA	8	affinity chromatography technology	Furitsu T (1993)	1
CCND2	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RAC1	7	GRB2	2	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4L	3	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology	Gao S (2009), Gao S (2009), Aragon E (2012), Herhaus L (2013), Gao S (2009), Gao S (2009), Yan X (2016)	7
HDAC6	0	ERBB3	3	protein complementation assay	Deribe YL (2009)	1
AKT1	1	NOTCH1	25	enzymatic study, two hybrid	Song J (2008), Daakour S (2016)	2
CDK9	3	RRM2	2	genetic interference	Shen JP (2017)	1
ERBB3	3	PIK3CA	8	affinity chromatography technology, affinity chromatography technology	Li J (2013), Hellyer NJ (2001)	2
HDAC6	0	PIK3CA	8	genetic interference	Shen JP (2017)	1