PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PIM1	2	MDM2	2	enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Wood NT (2009), Hogan C (2008), Hogan C (2008), Hogan C (2008), Hogan C (2008)	5
CDC20	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PIM1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mizuno K (2001), Mizuno K (2001), Mizuno K (2001), Shay KP (2005), Shay KP (2005)	5
SNX6	1	EGFR	5	affinity chromatography technology	Parks WT (2001)	1
EGFR	5	PIM1	2	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
FZR1	1	CDC25A	2	affinity chromatography technology, pull down, enzymatic study	Gao D (2009), Donzelli M (2002), Donzelli M (2002)	3
MDM2	2	SND1	4	affinity chromatography technology	Jacob AG (2014)	1
PIN1	0	PPP2CA	7	biochemical	Havugimana PC (2012)	1
SKP2	2	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, imaging technique	Amador V (2007), Hwang CY (2007), Calvisi DF (2009), Bendjennat M (2003), Wu L (2012), Wu L (2012), Abbas T (2008), Ungermannova D (2005), Chen TC (2014)	9
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
HSP90AA1	7	FZR1	1	genetic interference	Srivas R (2016)	1
EGFR	5	HSPA4	3	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Deribe YL (2009), Deribe YL (2009), Citri A (2002), Tong J (2008), Kotlyar M (2015), Petschnigg J (2014)	6
PIM1	2	DCP1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSP90AA1	7	MYC	2	affinity chromatography technology	Carystinos GD (2003)	1
PIM1	2	SND1	4	two hybrid, affinity chromatography technology	Leverson JD (1998), Leverson JD (1998)	2
PIM1	2	MYC	2	affinity chromatography technology, affinity chromatography technology	Zippo A (2007), Zippo A (2007)	2
FBXO7	1	HSP90AA1	7	affinity chromatography technology	Teixeira FR (2016)	1
TFPT	0	APP	1	pull down	Olah J (2011)	1
PIM1	2	PIM1	2	enzymatic study	Bachmann M (2004)	1
CBX1	0	CBX3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Rosnoblet C (2011), Hauri S (2016), Hauri S (2016)	8
CDC25A	2	EGFR	5	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Wang Z (2002), Wang Z (2002), Wang Z (2002), Wang Z (2002)	4
MAX	0	PPP2CA	7	affinity chromatography technology	Cheng J (2017)	1
CDC34	3	FBXO7	1	enzymatic study, pull down	Cenciarelli C (1999), Vingill S (2016)	2
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
MYC	2	PIN1	0	affinity chromatography technology, affinity chromatography technology	Arnold HK (2009), Yeh E (2004)	2
FBXO7	1	PIM1	2	enzymatic study	Teixeira FR (2016)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
BANP	1	CDC20	1	affinity chromatography technology, affinity chromatography technology	Paul D (2017), Paul D (2017)	2
PIM1	2	HSPA4	3	affinity chromatography technology	Shay KP (2005)	1
PPP2CA	7	PIM1	2	enzymatic study	Ma J (2007)	1
PIM1	2	BANP	1	two hybrid	Rolland T (2014)	1
CDKN1A	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe, affinity chromatography technology, imaging technique	Zhang Z (2004), Zhang Z (2004), Zhang Z (2004), Jin Y (2003), Jin Y (2003), Wang B (2010), Xu H (2010), Xu H (2010), Frum R (2007), Chen TC (2014)	10
FBXO7	1	SHMT1	1	enzymatic study	Teixeira FR (2016)	1
FZR1	1	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PIM1	2	BEND7	0	two hybrid	Rolland T (2014)	1
PIM1	2	EDC3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAX	0	BANP	1	two hybrid	Rolland T (2014)	1
HSP90AA1	7	SKP2	2	affinity chromatography technology	Taipale M (2012)	1
DCP1A	1	DDX6	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fenger-Gron M (2005), Fenger-Gron M (2005), Fenger-Gron M (2005), Li S (2014), Taipale M (2014), Taipale M (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
PIM1	2	ZBTB1	4	two hybrid	Rolland T (2014)	1
ELAVL1	0	CBX3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	SNX6	1	affinity chromatography technology	Abdelmohsen K (2009)	1
APP	1	MYC	2	pull down	Virok DP (2011)	1
SKP2	2	MYC	2	affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), Zhang Q (2013), Kim TA (2013), Jamal A (2015), Fujii M (2006)	9
DCP1B	1	DDX6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fenger-Gron M (2005), Taipale M (2014), Taipale M (2014), Huttlin EL (2015), Huttlin EL (2017)	5
PIM1	2	DCAF4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SKP2	2	CDC34	3	pull down, enzymatic study, pull down	Cen B (2010), Umanskaya K (2007), Ji P (2006)	3
DCP1B	1	DCP1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fenger-Gron M (2005), Fenger-Gron M (2005), Li S (2014), Li S (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	8
PIM1	2	NUMA1	10	affinity chromatography technology, enzymatic study	Bhattacharya N (2002), Bhattacharya N (2002)	2
CDC20	1	PPP2CA	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Craney A (2016), Craney A (2016), Craney A (2016)	3
FZR1	1	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Stewart S (2005), Stewart S (2005), Wang Y (2007), Wang Y (2007), Tian W (2012), Hyun SY (2013), Hyun SY (2013)	7
SHMT1	1	PIM1	2	two hybrid	Stelzl U (2005)	1
CDC34	3	PIM1	2	affinity chromatography technology	Cen B (2010)	1
SND1	4	APP	1	pull down	Olah J (2011)	1
MDM2	2	HSPA4	3	affinity chromatography technology	Lu TL (2010)	1
PIM1	2	CDKN1A	1	enzymatic study, pull down	Wang Z (2002), Wang Z (2002)	2
PIM1	2	FZR1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Cen B (2010), Cen B (2010), Cen B (2010)	3
ELAVL1	0	SKP2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
HSPA4	3	APP	1	affinity chromatography technology	Kumar P (2007)	1
PIM1	2	CBX1	0	affinity chromatography technology	Bhattacharya N (2002)	1
DCP1A	1	EDC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Fenger-Gron M (2005), Fenger-Gron M (2005), Fenger-Gron M (2005), Fenger-Gron M (2005), Fenger-Gron M (2005), Li S (2014), Taipale M (2014), Taipale M (2014), Huttlin EL (2015), Hein MY (2015), Tenekeci U (2016), Tenekeci U (2016), Huttlin EL (2017)	13
HEXIM2	0	BANP	1	affinity chromatography technology	Huttlin EL (2017)	1
MAX	0	CBX3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheng J (2017), Hauri S (2016), Hauri S (2016)	3
PIM1	2	CBX3	1	two hybrid, enzymatic study, pull down, affinity chromatography technology	Koike N (2000), Koike N (2000), Koike N (2000), Koike N (2000)	4
PIM1	2	MARK3	2	two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Bachmann M (2004), Bachmann M (2004), Bachmann M (2004), Huttlin EL (2015), Huttlin EL (2017)	5
CDC20	1	CDKN1A	1	affinity chromatography technology, affinity chromatography technology	Amador V (2007), Fogeron ML (2013)	2
PIN1	0	HEXIM2	0	two hybrid	Rolland T (2014)	1
MYC	2	MDM2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM2	2	HSP90AA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, biochemical, unspecified method, affinity chromatography technology	Lu TL (2010), Burch L (2004), Burch L (2004), Burch L (2004), Burch L (2004), Burch LR (2004), Okoro DR (2013)	7
ELAVL1	0	MYC	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CDKN1A	1	APP	1	pull down	Olah J (2011)	1
MYC	2	MAX	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, two hybrid, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), McMahon SB (2000), McMahon SB (1998), Cheng SW (1999), Mac Partlin M (2003), Mac Partlin M (2003), Blackwood EM (1991), Lee CM (2002), Billin AN (1999), Gupta K (1998), Meroni G (1997), Nair SK (2003), Nair SK (2003), FitzGerald MJ (1999), Meroni G (2000), Hatakeyama S (2005), Bandyopadhyay S (2010), Matsuoka Y (2009), Cowling VH (2006), Wang Z (2006), Faiola F (2005), Siegel PM (2003), Veldman T (2003), Patel JH (2004), Liu T (2007), Zhang Y (2007), Gordan JD (2007), Gordan JD (2007), Gargano B (2007), Zippo A (2007), Zippo A (2007), Zhang P (2010), Kim J (2010), Kim J (2010), Kim J (2010), Kim J (2010), Koch HB (2007), Koch HB (2007), Patel JH (2006), Lavigne P (1998), Amente S (2007), Ayer DE (1993), Huang Z (2004), Huang Z (2004), Okano HJ (1999), Agrawal P (2010), Agrawal P (2010), Wong WJ (2013), Wang J (2011), Yu L (2009), Liu X (2003), Hein MY (2015), Li X (2015), Li X (2015), Kalkat M (2014), Hauri S (2016)	56
PIM1	2	HIST2H3C	0	enzymatic study	Zippo A (2007)	1
FH	0	PIM1	2	two hybrid	Rolland T (2014)	1
PIM1	2	TFPT	0	two hybrid	Rolland T (2014)	1
PIM1	2	ABCB1	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Xie Y (2010), Xie Y (2010), Xie Y (2010), Xie Y (2010)	4
FBXO7	1	MARK3	2	enzymatic study	Teixeira FR (2016)	1
NHLH1	0	PIM1	2	two hybrid	Rolland T (2014)	1
PIM1	2	FXR2	2	two hybrid	Rolland T (2014)	1
PIM1	2	NFATC1	12	enzymatic study, affinity chromatography technology	Rainio EM (2002), Rainio EM (2002)	2
CBX1	0	MAX	0	affinity chromatography technology	Hauri S (2016)	1
PIM1	2	PPP2R5B	1	affinity chromatography technology, affinity chromatography technology	Ma J (2007), Ma J (2007)	2
SHMT1	1	SNX6	1	biochemical	Kristensen AR (2012)	1
DCP1B	1	EDC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Fenger-Gron M (2005), Li S (2014), Taipale M (2014), Taipale M (2014), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	8
SKP2	2	FZR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Calvisi DF (2009), Cen B (2010), Bashir T (2004), Bashir T (2004), Hu D (2011), Fukushima H (2013), Gao D (2009), Gao D (2009), Inuzuka H (2012), Inuzuka H (2012), Inuzuka H (2012), Huttlin EL (2017)	12
MYC	2	PPP2CA	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Arnold HK (2009), Junttila MR (2007), Cianfanelli V (2015), Cianfanelli V (2015)	4
CDC25A	2	CDC20	1	affinity chromatography technology	Li X (2016)	1
HSP90AA1	7	MAX	0	affinity chromatography technology	Taipale M (2012)	1
EDC3	1	DDX6	0	affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology	Fenger-Gron M (2005), Fenger-Gron M (2005), Fenger-Gron M (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	6
PIM1	2	PIN1	0	affinity chromatography technology	Ma J (2007)	1
ELAVL1	0	NHLH1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
MAX	0	TFPT	0	affinity chromatography technology	Boldt K (2016)	1
BANP	1	MDM2	2	pull down, affinity chromatography technology, affinity chromatography technology	Pavithra L (2009), Pavithra L (2009), Adhikary A (2014)	3
PIM1	2	DDX6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PIM1	2	CDC20	1	affinity chromatography technology, enzymatic study	Cen B (2010), Cen B (2010)	2
PPP2CA	7	PPP2R5B	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), McCright B (1996), McCright B (1996), Shamay M (2012), Letourneux C (2006), Letourneux C (2006), St-Denis N (2016), Yadav L (2017)	8
PIM1	2	SNX6	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Ishibashi Y (2001), Ishibashi Y (2001), Ishibashi Y (2001), Parks WT (2001)	4
PIM1	2	CDC25A	2	pull down, affinity chromatography technology	Mochizuki T (1999), Mochizuki T (1999)	2
SKP2	2	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cen B (2010), Bashir T (2004), Kelly A (2014), Craney A (2016), Huttlin EL (2017)	5
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
HSP90AA1	7	NUMA1	10	affinity chromatography technology	Falsone SF (2005)	1
DDX6	0	BEND7	0	two hybrid	Rolland T (2014)	1
PIM1	2	SKP2	2	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Cen B (2010), Cen B (2010), Cen B (2010), Cen B (2010)	4
PIM1	2	HEXIM2	0	two hybrid	Rolland T (2014)	1
HSP90AA1	7	CDKN1A	1	affinity chromatography technology	Jascur T (2005)	1
CDC25A	2	APP	1	pull down	Olah J (2011)	1
ELAVL1	0	PIM1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
MAX	0	PIM1	2	affinity chromatography technology, affinity chromatography technology	Zippo A (2007), Zippo A (2007)	2
PIM1	2	APP	1	pull down	Olah J (2011)	1
PIM1	2	DCP1B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2