PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TNIP1	1	PIK3CD	4	affinity chromatography technology	Wang HB (2007)	1
PIK3CD	4	PIK3R1	6	pull down, affinity chromatography technology, affinity chromatography technology	Vanhaesebroeck B (1997), Vanhaesebroeck B (1997), Hein MY (2015)	3
PIK3CD	4	PIK3CG	3	pull down, affinity chromatography technology	Vanhaesebroeck B (1997), Vanhaesebroeck B (1997)	2
CRK	0	PIK3R3	0	affinity chromatography technology, two hybrid	Brehme M (2009), Grossmann A (2015)	2
HRAS	2	PIK3CG	3	x-ray crystallography	Pacold ME (2000)	1
PIK3R3	0	PIK3CD	4	affinity chromatography technology	Huttlin EL (2017)	1
PIK3R1	6	HRAS	2	affinity chromatography technology, pull down, imaging technique	Hanna AN (1999), Rodriguez-Viciana P (1997), Chen TC (2014)	3
CRK	0	PIK3CD	4	affinity chromatography technology	Brehme M (2009)	1
PIK3R3	0	PIK3R1	6	affinity chromatography technology	Huttlin EL (2017)	1
PIK3CD	4	PIK3R2	3	pull down, affinity chromatography technology, affinity chromatography technology	Vanhaesebroeck B (1997), Vanhaesebroeck B (1997), Brehme M (2009)	3
TAGLN	1	PIK3CD	4	affinity chromatography technology, pull down	Lv P (2012), Lv P (2012)	2
CRK	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	Gelkop S (2001), Gelkop S (2001), Garcia-Guzman M (2000), Brehme M (2009), Grossmann A (2015), Chen TC (2014)	6
PIK3R2	3	PIK3R3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
HRAS	2	PIK3CD	4	two hybrid	Boettner B (2000)	1
TNIP1	1	PIK3R1	6	affinity chromatography technology	Wang HB (2007)	1
PIK3R2	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
AKT2	1	PIK3CD	4	biochemical	Wan C (2015)	1
ASCC2	3	PIK3CD	4	two hybrid	Stelzl U (2005)	1
PIK3R2	3	CRK	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Brehme M (2009), Brehme M (2009), Grossmann A (2015)	3