PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PML	7	PIN1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Reineke EL (2008), Reineke EL (2008), Reineke EL (2010), Reineke EL (2010), Lim JH (2011), El Asmi F (2014)	6
PIN1	0	SMAD3	1	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, two hybrid	Nakano A (2009), Nakano A (2009), Nakano A (2009), Aragon E (2011), Matsuura I (2010), Matsuura I (2010), Wang J (2011)	7
PLK1	0	CDC25C	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology	Roshak AK (2000), Izumi H (2009), Izumi H (2009), Yun SM (2009)	4
PIN1	0	SMAD2	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakano A (2009), Nakano A (2009), Matsuura I (2010), Matsuura I (2010)	4
PLK1	0	TP53	0	enzymatic study	Dias SS (2009)	1
PIN1	0	TP53	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down	Wulf GM (2002), Wulf GM (2002), Zacchi P (2002), Zacchi P (2002), Vinayagam A (2011), Mantovani F (2007)	6
SMAD3	1	NCOA3	3	affinity chromatography technology	Xi Q (2008)	1
PIN1	0	PLK1	0	affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Shen M (1998), Shen M (1998), Shen M (1998), Lu PJ (1999), Eckerdt F (2005), Eckerdt F (2005)	6
TP53	0	SMAD2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Tateossian H (2009), Lu D (2013), Chen TC (2014)	5
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
PIN1	0	FADD	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Oh J (2013), Oh J (2013), Oh J (2013), Oh J (2013)	4
TP53	0	PML	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014)	15
PIN1	0	PKM	1	two hybrid, pull down, pull down, affinity chromatography technology, unspecified method, enzymatic study	Vinayagam A (2011), Ingham RJ (2005), Yang W (2012), Yang W (2012), Yang W (2012), Yang W (2012)	6
PIN1	0	CDC25C	0	affinity chromatography technology, far western blotting, affinity chromatography technology, unspecified method, affinity chromatography technology	Shen M (1998), Shen M (1998), Shen M (1998), Goldstrohm AC (2001), Lu PJ (1999)	5
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
PML	7	PKM	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shimada N (2008), Shimada N (2008), Shimada N (2008)	3
NCOA3	3	PIN1	0	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Yi P (2005), Yi P (2005), Yi P (2005), Yi P (2005), Yi P (2005)	5
SMAD3	1	PML	7	affinity chromatography technology	Lin HK (2004)	1
PML	7	SMAD2	5	affinity chromatography technology	Lin HK (2004)	1
TP53	0	NCOA3	3	pull down	Lee SK (1999)	1
SMAD2	5	NCOA3	3	affinity chromatography technology, affinity chromatography technology	Xi Q (2008), He W (2006)	2