PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PITX3	2	PARK7	0	imaging technique	Reddy SD (2011)	1
PITX3	2	MTA1	3	imaging technique	Reddy SD (2011)	1
SFPQ	2	NONO	3	two hybrid, affinity chromatography technology, pull down, pull down, pull down, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Peng R (2002), Peng R (2002), Peng R (2002), Ito T (2008), Dong X (2007), Havugimana PC (2012), Wang J (2011), Hall-Pogar T (2007), Wan C (2015), Huttlin EL (2017)	10
MTA1	3	PARK7	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Reddy SD (2011), Reddy SD (2011), Reddy SD (2011), Opsahl JA (2010)	4
PITX3	2	NONO	3	affinity chromatography technology	Jacobs FM (2009)	1
PARK7	0	SFPQ	2	affinity chromatography technology, affinity chromatography technology	Xu J (2005), Xu J (2005)	2
PITX3	2	SFPQ	2	affinity chromatography technology, affinity chromatography technology	Jacobs FM (2009), Jacobs FM (2009)	2
NONO	3	PARK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang C (2008), Xu J (2005), Xu J (2005)	3