PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PKD1	18	SIAH1	2	two hybrid, affinity chromatography technology	Kim H (2004), Kim H (2004)	2
GAN	4	PKD1	18	affinity chromatography technology	Johnson-Kerner BL (2015)	1
JADE1	6	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, enzymatic study	Chitalia VC (2008), Chitalia VC (2008), Chitalia VC (2008)	3
PKD1	18	MARK2	6	enzymatic study	Watkins JL (2008)	1
PKD1	18	RGS7	4	two hybrid, affinity chromatography technology, pull down	Kim E (1999), Kim E (1999), Kim E (1999)	3
PTK2	2	PKD1	18	affinity chromatography technology	Geng L (2000)	1
CFTR	5	PKD1	18	affinity chromatography technology	Wang X (2006)	1
PKD2	1	ATP1A1	9	biochemical	Newby LJ (2002)	1
PKD1	18	COL2A1	9	pull down	Weston BS (2001)	1
PKD1	18	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Geng L (2000), Geng L (2000)	2
PKD1	18	PKD1	18	biochemical	Newby LJ (2002)	1
PKD1	18	KRT18	2	pull down	Xu GM (2001)	1
CFTR	5	CTNNB1	30	affinity chromatography technology	Pankow S (2015)	1
FN1	17	KRT18	2	affinity chromatography technology	Humphries JD (2009)	1
CFTR	5	KRT18	2	affinity chromatography technology	Pankow S (2015)	1
PKD1	18	ATP1A1	9	biochemical	Newby LJ (2002)	1
HDAC9	7	PKD1	18	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study	Dequiedt F (2005), Dequiedt F (2005), Parra M (2005), Parra M (2005), Parra M (2005)	5
PKD1	18	COL1A1	1	pull down	Malhas AN (2002)	1
PKD1	18	JADE1	6	affinity chromatography technology, affinity chromatography technology	Foy RL (2012), Foy RL (2012)	2
PKD1	18	PKD2	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Tsiokas L (1997), Tsiokas L (1999), Tsiokas L (1997), Newby LJ (2002), Newby LJ (2002), Newby LJ (2002)	6
PKD1	18	FN1	17	pull down	Malhas AN (2002)	1
SIAH1	2	CTNNB1	30	enzymatic study, affinity chromatography technology, affinity chromatography technology	Dimitrova YN (2010), Jumpertz S (2014), Shin M (2016)	3