PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDH5	2	PLD1	5	affinity chromatography technology	Huttlin EL (2017)	1
TEX264	0	PLD1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VHL	0	PLD1	5	affinity chromatography technology, pull down, pull down	Park MH (2014), Park MH (2014), Park MH (2014)	3
PLCG2	11	PRKCA	7	affinity chromatography technology	Wang J (2006)	1
SPACA1	1	PLD1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PLD1	5	ARF6	0	affinity chromatography technology	Vitale N (2002)	1
VHL	0	EGLN1	3	affinity chromatography technology, affinity chromatography technology, pull down	Foxler DE (2012), Zhang CS (2015), Zhang CS (2015)	3
ARF1	1	PLD1	5	affinity chromatography technology, biochemical	Kim JH (1998), Wan C (2015)	2
APBA2	1	PLD1	5	affinity chromatography technology	Huttlin EL (2017)	1
CDC42	3	PLD1	5	pull down, affinity chromatography technology	Walker SJ (2000), Walker SJ (2000)	2
ZRANB2	0	PLD1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RHOA	0	PKN1	4	pull down, two hybrid, pull down, two hybrid, far western blotting, pull down, x-ray crystallography	Riento K (2003), Riento K (2003), Alberts AS (1998), Flynn P (1998), Flynn P (1998), Flynn P (1998), Maesaki R (1999)	7
SRC	2	SNCA	0	enzymatic study	Ellis CE (2001)	1
PLD1	5	PEA15	0	two hybrid, pull down, affinity chromatography technology, two hybrid	Zhang Y (2000), Zhang Y (2000), Zhang Y (2000), Nagarajan A (2014)	4
PLD1	5	HIF1A	1	affinity chromatography technology, pull down	Park MH (2014), Park MH (2014)	2
UBE2O	5	PLD1	5	affinity chromatography technology	Huttlin EL (2017)	1
ATP6AP2	2	RHOA	0	affinity chromatography technology	Hein MY (2015)	1
TNFRSF19	5	PLD1	5	affinity chromatography technology	Huttlin EL (2017)	1
KCTD17	0	PLD1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PLD1	5	SNCA	0	affinity chromatography technology, pull down	Ahn BH (2002), Ahn BH (2002)	2
AMPH	4	BIN1	2	affinity chromatography technology, affinity chromatography technology	Wigge P (1997), Huttlin EL (2017)	2
VHL	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, far western blotting, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down, protein complementation assay, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Corn PG (2003), Li Z (2003), Mahon PC (2001), Tanimoto K (2000), Min JH (2002), Yu F (2001), Yu F (2001), Jung JE (2008), Jung JE (2008), Andre H (2008), Park YK (2008), Kim BY (2008), Park SS (2008), Baek JH (2007), Baek JH (2007), Baek JH (2007), Kondo S (2006), Ietta F (2006), Kwon SJ (2005), Bae MK (2005), Baek JH (2005), Hon WC (2002), Hon WC (2002), Lewis MD (2004), Kasuno K (2004), Metzen E (2003), Metzen E (2003), Zhou J (2003), Yuan Y (2003), Maynard MA (2003), Jeong JW (2002), Yoo YG (2008), Hansen WJ (2002), Masson N (2001), Masson N (2001), Clifford SC (2001), Jaakkola P (2001), Jaakkola P (2001), Kamura T (2000), Kamura T (2000), Kamura T (2000), Ohh M (2000), Ohh M (2000), Cockman ME (2000), Cockman ME (2000), Sufan RI (2006), Chang CC (2011), Sufan RI (2009), Stickle NH (2004), Luo W (2010), Lee HY (2011), Roe JS (2011), Ivan M (2001), Ivan M (2001), Huang LE (2002), Callapina M (2005), Callapina M (2005), Maranchie JK (2002), DAngelo G (2003), DAngelo G (2003), Miller F (2005), Grosfeld A (2007), Grosfeld A (2007), Rajakumar A (2008), Bonicalzi ME (2001), Bemis L (2004), Berra E (2001), Yu F (2001), Bex C (2007), Zhou J (2012), Wiesener MS (2002), Maxwell PH (1999), Maxwell PH (1999), Lee SH (2012), Lee SH (2012), Ivan M (2002), Aprelikova O (2009), Choi CY (2009), Choi CY (2009), Heir P (2013), Russell RC (2008), Russell RC (2008), Park JH (2011), Park JH (2011), Liu Q (2013), Yeh IJ (2013), Choi YK (2010), Yang F (2014), Yang F (2014), Yang F (2014), Parsanejad M (2014), Yang C (2013), Yang C (2013), Chen K (2013), Park MH (2014), Gerez J (2015), Hein MY (2015), Park MH (2015), Fu R (2016), Alahari S (2015), Zhang CS (2015), Song D (2013), Chen K (2016), Hicks KC (2016), Groulx I (2002), Groulx I (2002), Groulx I (2002), Huttlin EL (2017), Guo J (2016), Sun W (2017), Sun W (2017), Guo J (2016), Li YM (2005), Yoo YG (2004), Kimura M (2008), Ferrer CM (2014)	116
PLD1	5	ACTG1	5	affinity chromatography technology, pull down	Kusner DJ (2002), Kusner DJ (2002)	2
EGLN1	3	SRC	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Lee HY (2011), Lee HY (2011), Lee HY (2011), Lee HY (2011), Lee HY (2011)	5
RHEX	0	PKN1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIF1A	1	SRC	2	imaging technique, affinity chromatography technology	Gray MJ (2005), Ruas JL (2005)	2
SRC	2	PLD1	5	enzymatic study	Ahn BH (2003)	1
PLCG2	11	PLD1	5	affinity chromatography technology	Wang J (2006)	1
PLD1	5	RHOA	0	enzymatic study, pull down, affinity chromatography technology, pull down, unspecified method	Genth H (2003), Genth H (2003), Cai S (2001), Cai S (2001), Cai S (2001)	5
PRKCA	7	PLD1	5	affinity chromatography technology	Oka M (2003)	1
RALA	1	ARF1	1	pull down	Kim JH (1998)	1
POLH	1	PLD1	5	affinity chromatography technology	Hein MY (2015)	1
CACNG5	0	PLD1	5	affinity chromatography technology	Huttlin EL (2017)	1
PLCG2	11	KCTD17	0	two hybrid	Grossmann A (2015)	1
HIF1A	1	EGLN1	3	pull down, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Percy MJ (2006), Baek JH (2005), Yoo YG (2008), Chowdhury R (2009), Choi YK (2010), Park MH (2014), Park MH (2015), Park MH (2015), Barth S (2007), Song D (2013), Guo J (2016), Kumar P (2015)	12
ATP6AP2	2	PLD1	5	affinity chromatography technology	Hein MY (2015)	1
RALA	1	PLD1	5	pull down, pull down	Luo JQ (1997), Kim JH (1998)	2
PLD1	5	AMPH	4	genetic interference, pull down, affinity chromatography technology	Lee C (2000), Lee C (2000), Lee C (2000)	3
GPR156	2	PLD1	5	affinity chromatography technology	Huttlin EL (2017)	1
EGLN1	3	PLD1	5	affinity chromatography technology, pull down, affinity chromatography technology	Park MH (2014), Park MH (2014), Park MH (2014)	3
PLD1	5	BIN1	2	genetic interference, pull down	Lee C (2000), Lee C (2000)	2
RHEX	0	PLD1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ING3	3	PLD1	5	affinity chromatography technology	Hein MY (2015)	1
RHEB	2	PLD1	5	affinity chromatography technology, pull down, enzymatic study	Sun Y (2008), Sun Y (2008), Sun Y (2008)	3
PLD1	5	PKN1	4	affinity chromatography technology, pull down	Oishi K (2001), Oishi K (2001)	2
C5AR2	1	PLD1	5	affinity chromatography technology	Huttlin EL (2017)	1
MIER2	0	PLD1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OSBPL5	5	PLD1	5	affinity chromatography technology	Huttlin EL (2017)	1
RALA	1	ARF6	0	affinity chromatography technology	Xu L (2003)	1
ATP6AP2	2	RALA	1	affinity chromatography technology	Hein MY (2015)	1
CEP135	2	PLD1	5	affinity chromatography technology	Hein MY (2015)	1