PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FN1	17	PLG	3	pull down	Moser TL (1993)	1
KLK2	0	SERPINF2	0	pull down	Mikolajczyk SD (1998)	1
SERPINF2	0	SSR1	1	two hybrid	Wang J (2011)	1
BCAP31	0	SERPINF2	0	two hybrid	Wang J (2011)	1
SERPINF2	0	CFD	2	pull down	Turner RB (2002)	1
ELANE	0	SERPINF2	0	enzymatic study, enzymatic study	Brower MS (1982), Shieh BH (1987)	2
PRSS1	0	SERPINF2	0	enzymatic study	Shieh BH (1987)	1
FN1	17	SERPINF2	0	affinity chromatography technology	Moussavi-Harami SF (2013)	1
PLG	3	SERPINF2	0	pull down, enzymatic study	Wiman B (1979), Shieh BH (1987)	2
CANX	4	SERPINF2	0	affinity chromatography technology	Chung DH (2000)	1
KLK13	1	SERPINF2	0	pull down	Kapadia C (2004)	1
BCAP31	0	CANX	4	affinity chromatography technology, biochemical	Zuppini A (2002), Breckenridge DG (2002)	2