PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RTCB	1	MTA2	1	affinity chromatography technology	Boldt K (2016)	1
RFX3	7	MTA2	1	affinity chromatography technology	Boldt K (2016)	1
PDZD2	5	PTOV1	3	affinity chromatography technology	Pokharel YR (2015)	1
HDAC6	0	PTOV1	3	unspecified method	Hard RL (2010)	1
C16orf71	1	KLHDC2	1	affinity chromatography technology	Huttlin EL (2017)	1
BECN1	2	PTOV1	3	affinity chromatography technology	Behrends C (2010)	1
SFN	1	RACK1	2	affinity chromatography technology	Wilker EW (2007)	1
HDAC6	0	UBC	7	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Pai MT (2007), Pozo FM (2011), Sekimoto T (2010), Kovacs JJ (2004), Hao R (2013), Lee JH (2013), Nakashima H (2014), Banerjee I (2014), Hao R (2013), Zhang X (2017), Yu Q (2018)	11
SFN	1	RPS6	1	affinity chromatography technology	Wilker EW (2007)	1
MAPK6	1	UBC	7	affinity chromatography technology	Rodriguez J (2016)	1
PTOV1	3	PIN1	0	two hybrid	Stelzl U (2005)	1
PTOV1	3	DMTN	3	two hybrid	Stelzl U (2005)	1
SFN	1	PTOV1	3	affinity chromatography technology	Benzinger A (2005)	1
EGLN3	0	MAPK6	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Rodriguez J (2016), Rodriguez J (2016), Rodriguez J (2016), Rodriguez J (2016)	5
BECN1	2	UBC	7	pull down	Shi CS (2010)	1
RASSF9	0	PTOV1	3	affinity chromatography technology	Hauri S (2013)	1
CUL2	3	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Bish RA (2007), Wu K (2016)	3
PTOV1	3	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
RACK1	2	RPS6	1	biochemical	Marques N (2013)	1
PTOV1	3	RPS6	1	affinity chromatography technology, biochemical, imaging technique	Marques N (2013), Marques N (2013), Marques N (2013)	3
KLHDC2	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008), Bennett EJ (2010), Huttlin EL (2017)	4
CREBBP	29	PTOV1	3	affinity chromatography technology	Lee HK (2007)	1
KLHDC2	1	PTOV1	3	affinity chromatography technology	Huttlin EL (2017)	1
USP16	0	UBC	7	unspecified method, enzymatic study, pull down, unspecified method, pull down, pull down	Pai MT (2007), Faesen AC (2011), Kovacs JJ (2004), Ernst A (2013), Zhang X (2017), Kwasna D (2018)	6
XYLT2	3	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
HDAC1	4	PIN1	0	biochemical	Wan C (2015)	1
RTCB	1	XYLT2	3	affinity chromatography technology	Boldt K (2016)	1
RFX3	7	RTCB	1	affinity chromatography technology	Boldt K (2016)	1
MAPK6	1	PTOV1	3	affinity chromatography technology	Rodriguez J (2016)	1
RFX3	7	XYLT2	3	affinity chromatography technology	Boldt K (2016)	1
HDAC6	0	RPS6	1	biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology	Kappeler KV (2012), Kappeler KV (2012), Kappeler KV (2012), New M (2013)	4
UBC	7	PTOV1	3	pull down	Nathan JA (2013)	1
MAPK6	1	RACK1	2	two hybrid	Vinayagam A (2011)	1
C16orf71	1	PTOV1	3	affinity chromatography technology	Huttlin EL (2017)	1
RFX3	7	PTOV1	3	affinity chromatography technology	Boldt K (2016)	1
PTOV1	3	RACK1	2	two hybrid, affinity chromatography technology, pull down, pull down, imaging technique	Marques N (2013), Marques N (2013), Marques N (2013), Marques N (2013), Marques N (2013)	5
PTOV1	3	MTA2	1	affinity chromatography technology	Boldt K (2016)	1
UBC	7	FLOT1	0	affinity chromatography technology	Matsumoto M (2005)	1
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
PTOV1	3	SPTAN1	9	two hybrid	Stelzl U (2005)	1
PEX19	2	PTOV1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PTOV1	3	FLOT1	0	affinity chromatography technology, biochemical, imaging technique	Santamaria A (2005), Santamaria A (2005), Santamaria A (2005)	3
RACK1	2	CUL2	3	affinity chromatography technology	Zhang W (2008)	1
CUL2	3	RPS6	1	affinity chromatography technology	Bennett EJ (2010)	1
PTOV1	3	RTCB	1	affinity chromatography technology	Boldt K (2016)	1
PTOV1	3	XYLT2	3	affinity chromatography technology	Boldt K (2016)	1
EGLN3	0	PTOV1	3	affinity chromatography technology	Rodriguez J (2016)	1
RTCB	1	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
RIPK4	0	PTOV1	3	affinity chromatography technology	Rodriguez J (2016)	1
CUL2	3	PTOV1	3	affinity chromatography technology	Bennett EJ (2010)	1
MAPK6	1	SPTAN1	9	two hybrid	Vinayagam A (2011)	1
HDAC1	4	MTA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Yao YL (2003), You A (2001), Zhang Y (1999), Zhang Y (1999), Yasui D (2002), Banach-Orlowska M (2009), Banach-Orlowska M (2009), Cui Y (2006), Pflum MK (2001), Feng Q (2001), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Zhang Y (1998), Terhune SS (2010), Opsahl JA (2010), Wang Y (2009), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	27
XYLT2	3	MTA2	1	affinity chromatography technology	Boldt K (2016)	1
YWHAH	0	PTOV1	3	affinity chromatography technology	Hein MY (2015)	1
CUL2	3	RTCB	1	affinity chromatography technology	Bennett EJ (2010)	1
SFN	1	KLHDC2	1	affinity chromatography technology	Benzinger A (2005)	1
RFX3	7	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
USP16	0	PTOV1	3	unspecified method	Hard RL (2010)	1
EGLN3	0	CREBBP	29	affinity chromatography technology	Rodriguez J (2016)	1
RIPK4	0	YWHAH	0	affinity chromatography technology	Rodriguez J (2016)	1