PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FXYD6	0	TP53	0	two hybrid	Stelzl U (2005)	1
FXYD6	0	TRIM27	2	two hybrid	Stelzl U (2005)	1
FXYD6	0	CREB3L1	1	two hybrid	Rolland T (2014)	1
FXYD6	0	RBM48	1	two hybrid	Stelzl U (2005)	1
LMNA	2	FXYD6	0	two hybrid	Dittmer TA (2014)	1
C4BPA	3	FXYD6	0	two hybrid	Wang J (2011)	1
PPP1CC	2	FXYD6	0	two hybrid	Esteves SL (2012)	1
BCAR1	6	FXYD6	0	two hybrid	Stelzl U (2005)	1
CREB3	1	FXYD6	0	two hybrid	Yu H (2011)	1
TP53	0	LMNA	2	affinity chromatography technology	Horikawa I (2014)	1
LMNA	2	CREB3	1	two hybrid	Dittmer TA (2014)	1
FXYD6	0	CCDC90B	2	two hybrid	Stelzl U (2005)	1
FXYD6	0	HAUS2	2	two hybrid	Stelzl U (2005)	1
PPP1CC	2	TP53	0	affinity chromatography technology	Flores-Delgado G (2007)	1
SPPL2B	0	FXYD6	0	affinity chromatography technology	Huttlin EL (2017)	1
PPP1CC	2	LMNA	2	affinity chromatography technology, affinity chromatography technology	Cid C (2007), Depreux FF (2015)	2
FXYD6	0	SLC35E1	1	two hybrid	Stelzl U (2005)	1
FXYD6	0	TLE1	6	two hybrid	Stelzl U (2005)	1
TRIM27	2	TP53	0	affinity chromatography technology, pull down, enzymatic study	Chu Y (2011), Chu Y (2011), Chu Y (2011)	3
SLC39A12	8	FXYD6	0	affinity chromatography technology	Huttlin EL (2017)	1
FXYD6	0	GDF9	2	two hybrid	Stelzl U (2005)	1
CREB3L1	1	CREB3	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
FXYD6	0	UNC119	4	two hybrid	Stelzl U (2005)	1