PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CSNK1G1	0	RELA	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang Y (2014), Wang Y (2014), Wang Y (2014)	3
PPP1R14A	0	CSNK1G2	1	pull down	Zemlickova E (2004)	1
TMEM185A	0	CSNK1G2	1	affinity chromatography technology	Huttlin EL (2015)	1
CSNK1G1	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CSNK1G1	0	CEP76	1	two hybrid	Rolland T (2014)	1
CSNK1G3	5	CSNK1G1	0	affinity chromatography technology	Huttlin EL (2017)	1
CSNK1G1	0	CSNK1G2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PIFO	0	CSNK1G1	0	affinity chromatography technology	Huttlin EL (2017)	1
CSNK1G2	1	APP	1	pull down	Olah J (2011)	1
CSNK1G1	0	MKRN1	1	two hybrid	Vinayagam A (2011)	1
PPP1R14A	0	CSNK1G3	5	pull down	Zemlickova E (2004)	1
CSNK1G2	1	RUNDC3B	4	two hybrid	Vinayagam A (2011)	1
CSNK1G1	0	IKZF1	2	two hybrid	Vinayagam A (2011)	1
CSNK1G2	1	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
CSNK1G1	0	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
CSNK1G2	1	CSNK1G3	5	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	APP	1	pull down	Olah J (2011)	1
PPP1R14A	0	CSNK1G1	0	pull down	Zemlickova E (2004)	1
CSNK1G1	0	FAM219A	1	two hybrid	Vinayagam A (2011)	1
TMEM185A	0	CSNK1G1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GCH1	0	CSNK1G1	0	affinity chromatography technology	Chiarini A (2009)	1
PPP1R14A	0	APP	1	pull down	Olah J (2011)	1
KRTAP10-7	0	APP	1	pull down	Olah J (2011)	1
CSNK1G1	0	WDCP	2	two hybrid	Vinayagam A (2011)	1
CSNK1G2	1	WDCP	2	two hybrid	Vinayagam A (2011)	1
CSNK1G1	0	TRAF6	0	affinity chromatography technology	Wang Y (2014)	1
CSNK1G1	0	RUNDC3B	4	two hybrid	Vinayagam A (2011)	1