PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PSMC6	0	RFC2	0	biochemical	Wan C (2015)	1
MSH6	2	TOPBP1	5	affinity chromatography technology, affinity chromatography technology	Liu Y (2010), Liu Y (2010)	2
PMS2	4	PIK3C2A	7	affinity chromatography technology	Cannavo E (2007)	1
BRCA1	7	COPG1	5	affinity chromatography technology	Ertych N (2016)	1
PMS2	4	MSH6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cannavo E (2007), Matton N (2000), Matton N (2000), Plotz G (2003)	4
MMS19	5	MLH1	6	affinity chromatography technology	Stehling O (2012)	1
CYLD	2	ATAD3A	0	affinity chromatography technology	Elliott PR (2016)	1
PMS2	4	PSD3	4	affinity chromatography technology	Cannavo E (2007)	1
BRIP1	2	MSH2	4	genetic interference	Peng M (2014)	1
FAN1	2	PCNA	0	affinity chromatography technology	MacKay C (2010)	1
CTR9	10	PMS2	4	affinity chromatography technology	Hein MY (2015)	1
MLH1	6	PSD3	4	affinity chromatography technology	Cannavo E (2007)	1
PSMC6	0	PSMC3	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Kaneko T (2009), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	8
PMS2	4	FYN	1	affinity chromatography technology	Hein MY (2015)	1
BRCA1	7	PSMC3	0	affinity chromatography technology	Ertych N (2016)	1
EXO1	3	MLH1	6	pull down, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, pull down	Schmutte C (2001), Schmutte C (2001), Dherin C (2009), Dherin C (2009), Cannavo E (2007), Engels K (2011), Engels K (2011), Nielsen FC (2004), Andersen SD (2012), Jaeger AC (2001)	10
MLH1	6	RUVBL2	4	affinity chromatography technology	Cannavo E (2007)	1
BRCA1	7	TOPBP1	5	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenberg RA (2006), Mok MT (2010), Tian F (2013), Hill SJ (2014), Sakasai R (2012)	5
DDB1	6	UBC	7	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Matsumoto M (2005)	2
MSH2	4	MLH1	6	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Wang Y (2000), Matton N (2000), Plotz G (2003), Plotz G (2003), Chen TC (2014)	5
LMNA	2	PRKDC	12	affinity chromatography technology	Liu GH (2011)	1
BRCA1	7	KPNB1	3	affinity chromatography technology	Ertych N (2016)	1
CYLD	2	LMNA	2	affinity chromatography technology	Elliott PR (2016)	1
PMS2	4	PCNA	0	affinity chromatography technology, far western blotting, pull down	Cannavo E (2007), Dzantiev L (2004), Genschel J (2017)	3
ATAD3A	0	COPB1	0	biochemical	Wan C (2015)	1
PMS2	4	PSMC1	2	affinity chromatography technology	Cannavo E (2007)	1
PMS2	4	KPNB1	3	affinity chromatography technology	Cannavo E (2007)	1
UBC	7	RUVBL1	2	affinity chromatography technology	Matsumoto M (2005)	1
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
PMS2	4	NSUN2	0	affinity chromatography technology	Cannavo E (2007)	1
UBC	7	PSMD5	0	pull down, pull down	Baboshina OV (1996), Zhang X (2017)	2
BRCA1	7	MCM3	2	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	PSMC1	2	affinity chromatography technology	Ertych N (2016)	1
COPG1	5	COPG2	2	two hybrid, biochemical, affinity chromatography technology	Futatsumori M (2000), Havugimana PC (2012), Huttlin EL (2017)	3
UBC	7	PSMC3	0	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Jacobson AD (2014), Zhang X (2017)	3
PMS2	4	AIFM1	1	affinity chromatography technology	Cannavo E (2007)	1
PSMC6	0	RUVBL1	2	biochemical	Havugimana PC (2012)	1
PMS2	4	BRIP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cannavo E (2007), Xie J (2010), Peng M (2007), Peng M (2007), Hein MY (2015), Mori R (2013)	6
PMS2	4	RFC2	0	affinity chromatography technology	Cannavo E (2007)	1
PCNA	0	EXO1	3	imaging technique, far western blotting	Nielsen FC (2004), Dzantiev L (2004)	2
BRCA1	7	LMNA	2	affinity chromatography technology	Ertych N (2016)	1
XPO1	8	RUVBL2	4	affinity chromatography technology	Kirli K (2015)	1
BRCA2	6	XRCC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wilson JB (2010), Wilson JB (2008), Hussain S (2006), Hein MY (2015)	4
BRCA1	7	RFC2	0	affinity chromatography technology, affinity chromatography technology	Woods NT (2012), Hill SJ (2014)	2
CLSPN	1	PCNA	0	affinity chromatography technology	Yang XH (2008)	1
PCNA	0	RUVBL2	4	affinity chromatography technology	Ohta S (2002)	1
PMS2	4	DDB1	6	affinity chromatography technology	Cannavo E (2007)	1
BRCA1	7	XPO1	8	affinity chromatography technology	Ertych N (2016)	1
8339	0	TOPBP1	5	bioid	Lambert JP (2015)	1
MSH2	4	MSH3	4	affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, biochemical, pull down	Wang Y (2003), Guerrette S (1998), Bocker T (1999), Bocker T (1999), Acharya S (1996), Palombo F (1996), Havugimana PC (2012), Owen BA (2009)	8
BRCA2	6	PPP2CA	7	affinity chromatography technology	Park I (2017)	1
PMS2	4	ZNRD1	0	affinity chromatography technology	Hein MY (2015)	1
MMS19	5	XPO1	8	affinity chromatography technology	Stehling O (2012)	1
MLH1	6	RUVBL1	2	affinity chromatography technology	Cannavo E (2007)	1
SPRTN	0	MLH1	6	affinity chromatography technology	Mosbech A (2012)	1
MLH1	6	KPNA2	0	affinity chromatography technology, two hybrid	Cannavo E (2007), Rolland T (2014)	2
PMS2	4	MCM3	2	affinity chromatography technology	Cannavo E (2007)	1
XPO1	8	CYLD	2	affinity chromatography technology	Kirli K (2015)	1
MSH2	4	MSH6	2	biochemical, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, biochemical, affinity chromatography technology, imaging technique	Wang Y (2000), Wang Y (2003), Guerrette S (1998), Bocker T (1999), Bocker T (1999), Acharya S (1996), Matton N (2000), Matton N (2000), Yang Q (2004), Havugimana PC (2012), Gradia S (1997), Owen BA (2009), Wan C (2015), Hein MY (2015), Chen TC (2014)	15
FAN1	2	KPNB1	3	affinity chromatography technology	MacKay C (2010)	1
LMNA	2	RUVBL1	2	bioid	Roux KJ (2012)	1
BRCA1	7	PCNA	0	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
CYLD	2	AIFM1	1	affinity chromatography technology	Elliott PR (2016)	1
BRCA1	7	RUVBL2	4	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
UBC	7	RFC2	0	affinity chromatography technology	Matsumoto M (2005)	1
BRCA2	6	PCNA	0	affinity chromatography technology	Brough R (2012)	1
MLH1	6	PCNA	0	far western blotting, pull down	Dzantiev L (2004), Genschel J (2017)	2
NSF	3	PMS2	4	biochemical	Havugimana PC (2012)	1
XPO1	8	COPB1	0	affinity chromatography technology	Kirli K (2015)	1
CYLD	2	DDB1	6	affinity chromatography technology	Elliott PR (2016)	1
UBR5	13	UBC	7	pull down, x-ray crystallography, pull down	Kozlov G (2007), Kozlov G (2007), Zhang X (2017)	3
PMS2	4	UBR5	13	affinity chromatography technology	Cannavo E (2007)	1
MLH1	6	BRIP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cannavo E (2007), Xie J (2010), Xie J (2010), Xie J (2010), Peng M (2007), Peng M (2007), Peng M (2007), Peng M (2014), Mori R (2013), Guo M (2014)	10
SMARCA4	19	TOPBP1	5	affinity chromatography technology	Cohen SM (2010)	1
MLH1	6	MSH3	4	affinity chromatography technology, two hybrid	Cannavo E (2007), Rolland T (2014)	2
PSMD5	0	PSMC3	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
PSMC3	0	RFC2	0	biochemical	Wan C (2015)	1
EXO1	3	MSH3	4	pull down	Schmutte C (2001)	1
DDB1	6	PCNA	0	affinity chromatography technology	Angers S (2006)	1
PMS2	4	COPG1	5	affinity chromatography technology	Cannavo E (2007)	1
PMS2	4	PSMC3	0	affinity chromatography technology	Cannavo E (2007)	1
PRKDC	12	BRCA1	7	unspecified method	Kim ST (1999)	1
PSMD5	0	MCM3	2	biochemical	Wan C (2015)	1
EXO1	3	PMS2	4	affinity chromatography technology, affinity chromatography technology	Schmutte C (2001), Cannavo E (2007)	2
BRCA1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
PSMC3	0	RUVBL1	2	biochemical	Havugimana PC (2012)	1
PMS2	4	COPG2	2	affinity chromatography technology	Cannavo E (2007)	1
BRCA1	7	KPNA2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Chen CF (1996), Hill SJ (2014), Ertych N (2016)	3
UBC	7	PSMC6	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
MLH1	6	PMS2	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, pull down, pull down, pull down, affinity chromatography technology	Mac Partlin M (2003), Mac Partlin M (2003), Kondo E (2001), Kondo E (2001), Kondo E (2001), Kondo E (2001), Guerrette S (1999), Dherin C (2009), Cannavo E (2007), Cannavo E (2007), Cannavo E (2007), Cannavo E (2007), Xie J (2010), Peng M (2007), Nielsen FC (2004), Matton N (2000), Plotz G (2003), Havugimana PC (2012), Brieger A (2010), Dzantiev L (2004), Jaeger AC (2001), Sacho EJ (2008), Hein MY (2015)	23
KPNB1	3	EXO1	3	pull down	Andersen SD (2012)	1
MLH1	6	PIK3C2A	7	affinity chromatography technology	Cannavo E (2007)	1
PSMC2	2	UBC	7	pull down, pull down	Jacobson AD (2014), Zhang X (2017)	2
BRCA1	7	MSH2	4	two hybrid, pull down, biochemical, affinity chromatography technology, genetic interference	Wang Q (2001), Wang Q (2001), Wang Y (2000), Wada-Hiraike O (2005), Peng M (2014)	5
PMS2	4	TOPBP1	5	affinity chromatography technology, affinity chromatography technology	Liu Y (2010), Liu Y (2010)	2
PSMC2	2	PSMD5	0	two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, two hybrid, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Gorbea C (2000), Roelofs J (2009), Kaneko T (2009), Kaneko T (2009), Shim SM (2012), Shim SM (2012), Shim SM (2012), Havugimana PC (2012), Rolland T (2014), Wan C (2015), Yu H (2011), Huttlin EL (2017), Sun S (2017)	14
MMS19	5	KPNA2	0	affinity chromatography technology	Stehling O (2012)	1
BRCA1	7	PMS2	4	affinity chromatography technology	Hill SJ (2014)	1
KPNB1	3	NSF	3	affinity chromatography technology	Hein MY (2015)	1
XRCC3	1	MMS19	5	affinity chromatography technology	Hein MY (2015)	1
PMS2	4	PSMD5	0	affinity chromatography technology	Cannavo E (2007)	1
TOPBP1	5	BRIP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gong Z (2010), Gong Z (2010), Gong Z (2010), Gong Z (2010), Sakasai R (2012), Sakasai R (2012), Guo M (2014)	7
PMS2	4	PSD2	1	affinity chromatography technology	Cannavo E (2007)	1
XPO1	8	COPG2	2	affinity chromatography technology	Kirli K (2015)	1
PMS2	4	PPP2CA	7	affinity chromatography technology	Cannavo E (2007)	1
PMS2	4	ATAD3A	0	affinity chromatography technology	Cannavo E (2007)	1
PMS2	4	COPB1	0	affinity chromatography technology	Cannavo E (2007)	1
5379	0	PMS2	4	biochemical	Havugimana PC (2012)	1
PMS2	4	MSH2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cannavo E (2007), Matton N (2000), Plotz G (2003)	3
KPNB1	3	KPNA2	0	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Nagoshi E (2001), Koehler M (1999), Kutay U (1997), Hein MY (2015), Huttlin EL (2017)	5
BRCA2	6	BRCA1	7	affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sarkisian CJ (2001), Reuter TY (2003), Dong Y (2003), Chen J (1998), Chen J (1998), Villarroel MC (2011), Kumaraswamy E (2007), Sy SM (2009), Sy SM (2009), Sy SM (2009), Johnson N (2013), Hill SJ (2014), Loke J (2015)	13
PSMC2	2	PSMC6	0	biochemical, biochemical, biochemical, biochemical	Tipler CP (1997), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
MSH3	4	MSH6	2	biochemical	Havugimana PC (2012)	1
PMS2	4	CLSPN	1	affinity chromatography technology, affinity chromatography technology	Liu Y (2010), Liu Y (2010)	2
XRCC3	1	UBR5	13	affinity chromatography technology	Hein MY (2015)	1
PMS2	4	KPNA2	0	affinity chromatography technology	Cannavo E (2007)	1
XRCC3	1	PMS2	4	affinity chromatography technology	Hein MY (2015)	1
CYLD	2	PSMC3	0	affinity chromatography technology	Elliott PR (2016)	1
CYLD	2	PRKDC	12	affinity chromatography technology	Elliott PR (2016)	1
PCNA	0	RFC2	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cai J (1997), Pan ZQ (1993), Ohta S (2002), Han J (2014), Hein MY (2015)	5
PSMD5	0	PSMC6	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
PMS2	4	MSH3	4	affinity chromatography technology	Cannavo E (2007)	1
BRCA1	7	MLH1	6	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Cannavo E (2007), Suhasini AN (2011), Hill SJ (2014)	4
PMS2	4	PRKDC	12	affinity chromatography technology	Cannavo E (2007)	1
BRIP1	2	BRCA1	7	affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, unspecified method, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Botuyan MV (2004), Botuyan MV (2004), Botuyan MV (2004), Joo WS (2002), Yu X (2003), Yu X (2003), Rodriguez M (2003), Rodriguez M (2003), Clapperton JA (2004), Clapperton JA (2004), Yu X (2003), Kim H (2007), Sobhian B (2007), Suhasini AN (2011), Xie J (2010), Peng M (2007), Peng M (2007), Gupta R (2007), Nelson AC (2010), Nelson AC (2010), Nomine Y (2008), Dohrn L (2012), Drikos I (2009), Tischkowitz M (2008), Campbell SJ (2010), Hill SJ (2014), Wu W (2016), Suhasini AN (2013), Sakasai R (2012), Guo M (2014), Ertych N (2016)	31
RUVBL1	2	PRKDC	12	affinity chromatography technology	Izumi N (2010)	1
BRCA1	7	MSH3	4	unspecified method, pull down	Rodriguez M (2003), Wang Q (2001)	2
CYLD	2	MSH6	2	affinity chromatography technology	Elliott PR (2016)	1
PCNA	0	PRKDC	12	affinity chromatography technology	Ohta S (2002)	1
PMS2	4	PSMC6	0	affinity chromatography technology	Cannavo E (2007)	1
PMS2	4	PSMC2	2	affinity chromatography technology	Cannavo E (2007)	1
RUVBL1	2	RUVBL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, two hybrid, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ewing RM (2007), Jeronimo C (2007), Jeronimo C (2007), Puri T (2007), Rashid S (2009), Kim JH (2007), Kim JH (2007), McKeegan KS (2007), Lee JS (2010), Lee JS (2010), Cai Y (2007), Cai Y (2007), Ikura T (2000), Havugimana PC (2012), Venteicher AS (2008), Venteicher AS (2008), Bauer A (2000), Bauer A (2000), Bauer A (2000), Salzer U (1999), Izumi N (2010), Kristensen AR (2012), Rolland T (2014), Wan C (2015), Jeganathan A (2015), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017)	29
PMS2	4	FAN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cannavo E (2007), Smogorzewska A (2010), Smogorzewska A (2010), Smogorzewska A (2010), MacKay C (2010), Hein MY (2015), Hein MY (2015), St-Denis N (2016)	8
MLH1	6	ATAD3A	0	affinity chromatography technology	Cannavo E (2007)	1
XPO1	8	CLSPN	1	affinity chromatography technology	Kirli K (2015)	1
PSMC1	2	PSMD5	0	pull down, biochemical, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Gorbea C (2000), Kaneko T (2009), Havugimana PC (2012), Rolland T (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	7
MSH6	2	MLH1	6	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Matton N (2000), Matton N (2000), Plotz G (2003), Plotz G (2003)	5
MSH6	2	PCNA	0	far western blotting, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, far western blotting, affinity chromatography technology, biochemical, affinity chromatography technology	Kleczkowska HE (2001), Kleczkowska HE (2001), Clark AB (2000), Ohta S (2002), Jascur T (2011), Schoepf B (2012), Havugimana PC (2012), Dzantiev L (2004), Han J (2014), Wan C (2015), Hein MY (2015)	11
MLH1	6	AIFM1	1	affinity chromatography technology, two hybrid	Cannavo E (2007), Brieger A (2010)	2
PMS2	4	RUVBL1	2	affinity chromatography technology	Cannavo E (2007)	1
CYLD	2	RUVBL2	4	affinity chromatography technology	Elliott PR (2016)	1
BRCA1	7	NSF	3	affinity chromatography technology	Ertych N (2016)	1
COPB1	0	COPG1	5	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Futatsumori M (2000), Lowe M (1996), Futatsumori M (2000), Harter C (1998), Harter C (1998), Pavel J (1998), Wegmann D (2004), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	11
CYLD	2	PSMC1	2	affinity chromatography technology	Elliott PR (2016)	1
MLH1	6	UBC	7	affinity chromatography technology	Cannavo E (2007)	1
UBC	7	RUVBL2	4	affinity chromatography technology	Matsumoto M (2005)	1
PPP2CA	7	KPNB1	3	affinity chromatography technology	Glatter T (2009)	1
CYLD	2	PSMC6	0	affinity chromatography technology	Elliott PR (2016)	1
BRCA1	7	RUVBL1	2	affinity chromatography technology	Ertych N (2016)	1
RUVBL1	2	KPNB1	3	affinity chromatography technology	Jeronimo C (2007)	1
8339	0	PMS2	4	bioid	Lambert JP (2015)	1
PRKDC	12	PPP2CA	7	affinity chromatography technology	Douglas P (2010)	1
PMS2	4	CYLD	2	affinity chromatography technology	Cannavo E (2007)	1
MSH3	4	PCNA	0	far western blotting, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, two hybrid	Kleczkowska HE (2001), Kleczkowska HE (2001), Clark AB (2000), Ohta S (2002), Ohta S (2002), Rolland T (2014)	6
MLH1	6	KPNB1	3	affinity chromatography technology	Cannavo E (2007)	1
SMARCA4	19	KPNA2	0	affinity chromatography technology	Tando T (2010)	1
SPRTN	0	8339	0	affinity chromatography technology	Kim MS (2013)	1
BRCA1	7	MSH6	2	two hybrid, pull down, biochemical, affinity chromatography technology	Wang Q (2001), Wang Q (2001), Wang Y (2000), Hill SJ (2014)	4
UBC	7	COPB1	0	affinity chromatography technology, pull down	Matsumoto M (2005), Xu P (2017)	2
XPO1	8	CTR9	10	affinity chromatography technology	Kirli K (2015)	1
BRCA1	7	PSMC2	2	affinity chromatography technology	Ertych N (2016)	1
PSMC1	2	PSMC2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Gorbea C (2000), Hartmann-Petersen R (2001), Kaneko T (2009), Kaneko T (2009), Kim YC (2011), Kim YC (2011), Shim SM (2012), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	13
SPRTN	0	PSMC2	2	affinity chromatography technology	Kim MS (2013)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
BRCA1	7	PSMC6	0	affinity chromatography technology	Ertych N (2016)	1
XPO1	8	XRCC3	1	affinity chromatography technology	Kirli K (2015)	1
UBC	7	PSMC1	2	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
MLH1	6	PRKDC	12	affinity chromatography technology	Cannavo E (2007)	1
PMS2	4	SMARCA4	19	affinity chromatography technology	Cannavo E (2007)	1
BRCA1	7	COPB1	0	affinity chromatography technology	Ertych N (2016)	1
PPP2CA	7	PSMC6	0	biochemical	Havugimana PC (2012)	1
PCNA	0	MSH2	4	affinity chromatography technology, far western blotting	Ohta S (2002), Dzantiev L (2004)	2
REXO2	0	PMS2	4	biochemical	Wan C (2015)	1
SPRTN	0	PMS2	4	affinity chromatography technology	Mosbech A (2012)	1
PARD6A	0	PMS2	4	affinity chromatography technology	Hein MY (2015)	1
PSMC2	2	PSMC3	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Tipler CP (1997), Kim YC (2011), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	8
RUVBL2	4	KPNB1	3	affinity chromatography technology	Jeronimo C (2007)	1
PMS2	4	MMS19	5	affinity chromatography technology	Cannavo E (2007)	1
PSMC6	0	PSMC1	2	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
LMNA	2	PCNA	0	two hybrid	Dittmer TA (2014)	1
PMS2	4	UBC	7	affinity chromatography technology, pull down	Cannavo E (2007), Zhang X (2017)	2
PMS2	4	RUVBL2	4	affinity chromatography technology	Cannavo E (2007)	1
CLSPN	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lin SY (2004), Lin SY (2004), Sato K (2012)	3
FAN1	2	UBC	7	affinity chromatography technology, pull down, pull down	MacKay C (2010), Shereda RD (2010), Shereda RD (2010)	3
PARD6A	0	SMARCA4	19	affinity chromatography technology	Hein MY (2015)	1
PMS2	4	ABCA2	15	affinity chromatography technology	Hein MY (2015)	1
CYLD	2	PSMC2	2	affinity chromatography technology	Elliott PR (2016)	1
TOPBP1	5	DDB1	6	affinity chromatography technology	Wang J (2013)	1
XPO1	8	UBR5	13	affinity chromatography technology	Kirli K (2015)	1
PSMC2	2	XPO1	8	biochemical	Havugimana PC (2012)	1
MLH1	6	FAN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Cannavo E (2007), Smogorzewska A (2010), Smogorzewska A (2010), Smogorzewska A (2010), MacKay C (2010), MacKay C (2010), MacKay C (2010), Hein MY (2015), St-Denis N (2016)	9
COPB1	0	COPG2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Takatsu H (2001), Futatsumori M (2000), Wegmann D (2004), Havugimana PC (2012)	4
XPO1	8	COPG1	5	affinity chromatography technology	Kirli K (2015)	1
PSMC3	0	PSMC1	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
MSH6	2	PRKDC	12	affinity chromatography technology	Shahi A (2011)	1
LMNA	2	PMS2	4	biochemical	Havugimana PC (2012)	1
XPO1	8	RUVBL1	2	affinity chromatography technology	Kirli K (2015)	1
UBR5	13	TOPBP1	5	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Honda Y (2002), Honda Y (2002), Honda Y (2002), Honda Y (2002)	4
SPRTN	0	UBC	7	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Machida Y (2012), Machida Y (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Centore RC (2012), Davis EJ (2012)	7
PMS2	4	XPO1	8	affinity chromatography technology	Cannavo E (2007)	1
MSH6	2	CLSPN	1	affinity chromatography technology, affinity chromatography technology	Liu Y (2010), Liu Y (2010)	2
PSMC2	2	UBR5	13	biochemical	Wan C (2015)	1
PMS2	4	BRCA2	6	affinity chromatography technology	Cannavo E (2007)	1
BRCA1	7	PPP2CA	7	affinity chromatography technology	Woods NT (2012)	1
CYLD	2	PCNA	0	affinity chromatography technology	Elliott PR (2016)	1
DDB1	6	UBR5	13	affinity chromatography technology	Maddika S (2009)	1
8339	0	BRCA1	7	bioid	Lambert JP (2015)	1
MMS19	5	BRIP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stehling O (2012), Stehling O (2012), Gari K (2012), Gari K (2012)	4
MSH2	4	EXO1	3	two hybrid, pull down, pull down, pull down, pull down	Rasmussen LJ (2000), Schmutte C (1998), Schmutte C (2001), Dherin C (2009), Andersen SD (2012)	5
SPRTN	0	PCNA	0	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Centore RC (2012), Centore RC (2012), Ghosal G (2012), Ghosal G (2012), Ghosal G (2012), Ghosal G (2012), Machida Y (2012), Machida Y (2012), Davis EJ (2012), Davis EJ (2012), Juhasz S (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Juhasz S (2012), Centore RC (2012)	16
LMNA	2	BRIP1	2	bioid	Roux KJ (2012)	1
RFC2	0	PRKDC	12	biochemical	Kristensen AR (2012)	1
SPRTN	0	UBR5	13	affinity chromatography technology	Kim MS (2013)	1
BRCA1	7	SMARCA4	19	affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Hill DA (2004), Bochar DA (2000), Bochar DA (2000), Bochar DA (2000), Tu Z (2013), Ertych N (2016)	6
UBC	7	KPNB1	3	affinity chromatography technology	Matsumoto M (2005)	1