PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BRWD1	6	SMARCA4	19	affinity chromatography technology	Huang H (2003)	1
MMGT1	0	BRWD1	6	affinity chromatography technology	Hein MY (2015)	1
CUL3	17	BRWD1	6	affinity chromatography technology	Wimuttisuk W (2014)	1
CUL4A	2	CUL3	17	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
DDB1	6	BRWD1	6	affinity chromatography technology, biochemical	Angers S (2006), Wan C (2015)	2
COPS5	0	BRWD1	6	affinity chromatography technology	Bennett EJ (2010)	1
UBXN7	3	BRWD1	6	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Raman M (2015)	2
COPS5	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Rao F (2014), Pick E (2012), Groisman R (2003), Groisman R (2003), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	19
UBXN7	3	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	3
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
UBXN7	3	APP	1	pull down	Olah J (2011)	1
MMGT1	0	APP	1	pull down	Olah J (2011)	1
STAT3	0	COPS5	0	affinity chromatography technology	Nishimoto A (2013)	1
RDX	1	BRWD1	6	biochemical	Wan C (2015)	1
APPL1	1	BRWD1	6	two hybrid	Grossmann A (2015)	1
STAT3	0	BRWD1	6	two hybrid	Grossmann A (2015)	1
CUL3	17	SMARCA4	19	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
COPS5	0	SMARCA4	19	affinity chromatography technology	Bennett EJ (2010)	1
UBXN7	3	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
DDB1	6	COPS5	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Jin J (2006), Emberley ED (2012), Bennett EJ (2010), Olma MH (2009), He F (2013)	6
UBXN7	3	DDB1	6	affinity chromatography technology	Alexandru G (2008)	1
CALM1	0	RDX	1	pull down	Shen X (2005)	1
SMARCA4	19	STAT3	0	affinity chromatography technology, affinity chromatography technology, pull down	Giraud S (2004), Giraud S (2004), Giraud S (2004)	3
MYO5C	8	BRWD1	6	affinity chromatography technology	Hein MY (2015)	1
CALM1	0	BRWD1	6	pull down	Shen X (2005)	1
CUL3	17	CALM1	0	affinity chromatography technology	Bennett EJ (2010)	1
BRWD1	6	APP	1	pull down	Olah J (2011)	1
CUL4A	2	BRWD1	6	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Bennett EJ (2010)	2
COPS5	0	APP	1	pull down, affinity chromatography technology	Olah J (2011), Wang H (2013)	2