PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
SPATA5L1	2	RIPK4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
RIPK4	0	PRKCB	4	affinity chromatography technology, enzymatic study	Chen L (2001), Chen L (2001)	2
THBS3	3	RIPK4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKCD	2	PRKCB	4	affinity chromatography technology	Varjosalo M (2013)	1
BIRC3	1	RIPK4	0	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
XIAP	0	RIPK4	0	pull down, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011)	2
HIF1AN	0	RIPK4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016), Rodriguez J (2016), Rodriguez J (2016), Rodriguez J (2016)	5
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
BIRC2	1	RIPK4	0	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
PRKCD	2	RIPK4	0	affinity chromatography technology, affinity chromatography technology	Bhr C (2000), Rodriguez J (2016)	2
BTRC	1	RIPK4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loveless TB (2015), Loveless TB (2015), Rodriguez J (2016)	3
ENPP6	1	RIPK4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RIPK4	0	TRAF7	11	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2