PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BTK	1	IRAK1	1	affinity chromatography technology	Jefferies CA (2003)	1
IRAK1	1	PRKCZ	5	affinity chromatography technology	Hu J (2002)	1
TLR9	2	TRAF6	0	affinity chromatography technology	Yang M (2011)	1
RNF216	2	TLR9	2	two hybrid, two hybrid	Chuang TH (2004), Chuang TH (2004)	2
TOLLIP	3	TRAF6	0	affinity chromatography technology	Lee JY (2009)	1
TLR9	2	TRIM69	0	affinity chromatography technology	Yang M (2011)	1
MYD88	1	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen BC (2002), Wesche H (1999), Li S (2002), Fitzgerald KA (2001), Fitzgerald KA (2001), Li S (2011), Neumann D (2007), Zhou J (2011), Burns K (2003), Mizobe T (2007), Loiarro M (2007), Choi KC (2006), Rao N (2005), Rao N (2005), Li CH (2006)	15
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
TRAF6	0	SRC	2	affinity chromatography technology, pull down	Wong BR (1999), Liu A (2012)	2
TLR9	2	UGGT1	6	affinity chromatography technology	Li S (2011)	1
STUB1	4	SRC	2	pull down, affinity chromatography technology, imaging technique, enzymatic study	Yang M (2011), Yang M (2011), Yang M (2011), Yang M (2011)	4
SYK	3	TBK1	1	affinity chromatography technology	Lin YC (2013)	1
SRC	2	SYK	3	enzymatic study, affinity chromatography technology, enzymatic study	Kurosaki T (1994), Asazuma N (1997), Hirose M (2004)	3
TLR9	2	HSPA8	4	affinity chromatography technology	Yang M (2011)	1
TLR9	2	TRAF3	1	affinity chromatography technology	Li S (2011)	1
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
MYD88	1	TRAF6	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Zhou J (2011), Zhou J (2011), Zhang X (2013), Zhang X (2013), Hirata Y (2006)	6
TLR9	2	STK11IP	3	affinity chromatography technology	Li S (2011)	1
TRAF3	1	RNF216	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Nakhaei P (2009), Nakhaei P (2009), Zhao K (2016), Zhao K (2016)	4
SYK	3	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamada T (2001), Lin YC (2013), Wu NL (2014)	3
TLR9	2	TOLLIP	3	affinity chromatography technology	Li S (2011)	1
MYD88	1	SYK	3	affinity chromatography technology	Lin YC (2013)	1
IRAK1	1	STUB1	4	affinity chromatography technology	So J (2015)	1
TLR9	2	SYK	3	affinity chromatography technology	Lin YC (2013)	1
TOLLIP	3	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burns K (2000), Brissoni B (2006), Li S (2011), Lee JY (2009), Yagasaki Y (2004), Neumann D (2007), Ohnuma K (2005), Ohnuma K (2005), Jensen LE (2001), Rao N (2005), Lee HJ (2012), Lei L (2016)	12
MYD88	1	TLR9	2	two hybrid, affinity chromatography technology	Chuang TH (2004), Yang M (2011)	2
BTK	1	TLR9	2	two hybrid	Jefferies CA (2003)	1
BTK	1	SYK	3	affinity chromatography technology	Morrogh LM (1999)	1
TLR9	2	UNC93B1	0	affinity chromatography technology	Li S (2011)	1
TLR9	2	STUB1	4	affinity chromatography technology	Yang M (2011)	1
TLR9	2	TBK1	1	affinity chromatography technology	Yang M (2011)	1
MYD88	1	BTK	1	affinity chromatography technology	Jefferies CA (2003)	1
TLR9	2	PALD1	2	affinity chromatography technology	Li S (2011)	1
TLR9	2	CLGN	1	affinity chromatography technology	Li S (2011)	1
STUB1	4	HSPA8	4	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, unspecified method, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Tateishi Y (2004), Tateishi Y (2004), Jiang J (2001), Wang L (2011), Wang L (2011), Wang L (2011), Stankiewicz M (2010), Yang M (2011), Yang M (2011), Urushitani M (2004), Grelle G (2006), Kim SA (2005), Arndt V (2005), Alberti S (2004), Meacham GC (2001), Smith MC (2013), Smith MC (2013), Matsumura Y (2013), Spooner RA (2008), Taipale M (2014), Taipale M (2014), Heimdal K (2014), Grelle G (2006), Grelle G (2006), Kamynina E (2007), Zhang H (2015), Zhang H (2015), Zhang H (2015), Li P (2015), Guo Y (2016), Zhang H (2017), Pakdaman Y (2017)	35
TRAF6	0	PRKCZ	5	affinity chromatography technology	Sanz L (2000)	1
IRAK1	1	HSPA8	4	affinity chromatography technology	De Nardo D (2005)	1
PRKCZ	5	SRC	2	affinity chromatography technology, affinity chromatography technology	Seibenhener ML (1999), Seibenhener ML (1999)	2
SYK	3	TRAF3	1	affinity chromatography technology	Lin YC (2013)	1
TBK1	1	SRC	2	affinity chromatography technology	Johnsen IB (2009)	1
TLR9	2	SRC	2	affinity chromatography technology	Yang M (2011)	1
TRAF3	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kayagaki N (2007), Mankouri J (2010), Mankouri J (2010), Tzieply N (2012), Wang Y (2012), Ng MH (2011), Charoenthongtrakul S (2013), van Zuylen WJ (2012), van Zuylen WJ (2012), Karim R (2013), Chen X (2014), Peng Y (2014), Wang S (2013), Zhou Y (2016), Cai B (2017), Fang R (2017), Fang R (2017)	17
TRAF3	1	SRC	2	affinity chromatography technology, affinity chromatography technology	Wong BR (1999), Johnsen IB (2009)	2
MYD88	1	TRAF3	1	affinity chromatography technology	Zhou J (2011)	1
STYX	1	TLR9	2	affinity chromatography technology	Li X (2016)	1
TLR9	2	IRAK1	1	affinity chromatography technology	Yang M (2011)	1
TLR9	2	PRKCZ	5	affinity chromatography technology	Yang M (2011)	1
UNC93B1	0	IRAK1	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
STUB1	4	PRKCZ	5	pull down, affinity chromatography technology, imaging technique, enzymatic study	Yang M (2011), Yang M (2011), Yang M (2011), Yang M (2011)	4