PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CCNE1	1	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Harbour JW (1999), Manenti S (1999), Horton LE (1997), Higashi H (1996), Jiang W (1998), Connell-Crowley L (1997), Gaiddon C (2003), Zarkowska T (1997), Nakanishi M (1999)	9
TRIM25	5	PPP2R1B	4	affinity chromatography technology	Choudhury NR (2017)	1
CDK2	0	PARP1	3	affinity chromatography technology	Neganova I (2011)	1
POLD3	0	POLA1	0	biochemical	Havugimana PC (2012)	1
TP53	0	RPA1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Romanova LY (2004), Romanova LY (2004), Riva F (2001), Glanzer JG (2013)	4
GINS4	0	RPL36A	0	genetic interference	Horlbeck MA (2018)	1
POLA1	0	PPP2CA	7	affinity chromatography technology	Dehde S (2001)	1
RPA1	0	XRCC5	5	affinity chromatography technology	Marechal A (2014)	1
RPA1	0	MRE11	3	affinity chromatography technology	Marechal A (2014)	1
TRIM25	5	ALDH1L2	1	affinity chromatography technology	Choudhury NR (2017)	1
RPA1	0	WDHD1	4	affinity chromatography technology	Marechal A (2014)	1
MOV10	6	PRIM2	1	affinity chromatography technology	Castello A (2012)	1
RPA3	2	RPA2	0	biochemical, x-ray crystallography, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Havugimana PC (2012), Du Y (2009), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
TRIM25	5	UBA2	0	affinity chromatography technology	Choudhury NR (2017)	1
POLA2	2	PARP1	3	affinity chromatography technology, far western blotting	Dantzer F (1998), Dantzer F (1998)	2
CCNB1	3	CDC6	0	enzymatic study	Jiang W (1999)	1
STN1	0	PRIM2	1	affinity chromatography technology	Huttlin EL (2015)	1
RPA1	0	CCNA2	1	pull down	Gibbs E (1996)	1
CCNB1	3	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Di Fiore B (2010), Nishiyama A (2000), Wolthuis R (2008), Desai D (1995), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	11
MYC	2	MMS19	5	affinity chromatography technology	Koch HB (2007)	1
POLE	10	RPL36A	0	genetic interference	Horlbeck MA (2018)	1
CCNA2	1	HELB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SHMT2	3	PARP1	3	affinity chromatography technology	Castello A (2012)	1
TRIM25	5	MYC	2	affinity chromatography technology	Choudhury NR (2017)	1
MMS19	5	POLA1	0	affinity chromatography technology	Stehling O (2012)	1
NTRK1	1	CDK1	0	affinity chromatography technology	Emdal KB (2015)	1
MCM2	3	ENO1	3	affinity chromatography technology	Drissi R (2015)	1
NTRK1	1	SHMT2	3	affinity chromatography technology	Emdal KB (2015)	1
PARP1	3	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ju BG (2006), Galande S (1999), Galande S (1999), Galande S (1999), Idogawa M (2007), Li B (2004), Li B (2004), Yin H (2006), Yin H (2006), Sand-Dejmek J (2011), Wu T (2013)	11
CHEK1	2	XRCC5	5	affinity chromatography technology	Goudelock DM (2003)	1
HELB	1	POLA2	2	pull down	Taneja P (2002)	1
RPA1	0	RPA2	0	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Kristensen AR (2012), Ghospurkar PL (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Elia AE (2015), Elia AE (2015), Huttlin EL (2017), Feeney L (2017)	13
KRAS	1	POLA1	0	genetic interference	Luo J (2009)	1
MCM2	3	XRCC5	5	affinity chromatography technology	Drissi R (2015)	1
PCNA	0	ENO1	3	affinity chromatography technology, pull down	Naryzhny SN (2010), Naryzhny SN (2010)	2
MYC	2	UBA2	0	genetic interference	Kessler JD (2012)	1
MCM3	2	MCM2	3	two hybrid, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	8
SIRT7	1	MOV10	6	affinity chromatography technology	Tsai YC (2012)	1
PCNA	0	CHEK1	2	affinity chromatography technology	Scorah J (2008)	1
CCNA2	1	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Horton LE (1997), Higashi H (1996), Knudsen ES (1996), Jiang W (1998), Connell-Crowley L (1997), Gaiddon C (2003), Nakanishi M (1999)	7
STN1	0	POLA2	2	affinity chromatography technology	Huttlin EL (2017)	1
RPA3	2	PPP2CA	7	affinity chromatography technology	Marechal A (2014)	1
HUS1	1	POLA1	0	genetic interference	Horlbeck MA (2018)	1
PCNA	0	LIG1	4	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Ohta S (2002), Montecucco A (1998), Han J (2014), Ferry L (2017)	4
CDK2AP1	1	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology	Shintani S (2000), Shintani S (2000), Shintani S (2000)	3
RAE1	0	PRIM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
MMS19	5	PRIM1	1	affinity chromatography technology	Stehling O (2012)	1
CCNB1	3	PCNA	0	affinity chromatography technology, affinity chromatography technology	Zhang H (1993), Huttlin EL (2017)	2
TRIM25	5	PPP2CA	7	affinity chromatography technology	Choudhury NR (2017)	1
PPP2R1B	4	CDK1	0	affinity chromatography technology, affinity chromatography technology	Sablina AA (2007), Sablina AA (2007)	2
POLA1	0	PRIM1	1	biochemical, biochemical, biochemical, affinity chromatography technology	Kilkenny ML (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	4
POLA1	0	PPP2R1B	4	affinity chromatography technology	Dehde S (2001)	1
TP53	0	POLD3	0	genetic interference	Xie L (2013)	1
NTRK1	1	SMC1A	15	affinity chromatography technology	Emdal KB (2015)	1
TP53	0	RPA2	0	affinity chromatography technology	Li X (2015)	1
XRCC5	5	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matheos D (2002), Ohta S (2002), Balajee AS (2001)	3
RAE1	0	POLA1	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015)	2
CDC6	0	CDK2	0	affinity chromatography technology, enzymatic study	Saha P (1998), Jiang W (1999)	2
POLA1	0	WDHD1	4	biochemical	Wan C (2015)	1
CDK2	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Shintani S (2000), Nair JS (2009), Takaki T (2004), Shen WH (2004), He W (2003), Peiretti A (2003), Harbour JW (1999), Horton LE (1997), Higashi H (1996), Delston RB (2011), Kim KS (2002), Chen W (2004), Liberal V (2012), Boyer Arnold N (2005), Dynlacht BD (1997), Knudsen ES (1996), Jiang W (1998), De Luca A (1997), Chen Z (2002), Hara E (1997), Connell-Crowley L (1997), Matsuura I (2004), Chen J (1996), Gaiddon C (2003), Seo DW (2006), Zarkowska T (1997), Grimmler M (2007), Nakanishi M (1999), Pevarello P (2005), Iyer NG (2007), Chan HM (2001), Pan W (2001)	32
NTRK1	1	MCM3	2	affinity chromatography technology	Emdal KB (2015)	1
MCM2	3	TRIM25	5	affinity chromatography technology	Drissi R (2015)	1
EIF4G2	7	RPA2	0	two hybrid	Wang J (2011)	1
POLA1	0	PCNA	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
GINS4	0	WDHD1	4	biochemical	Wan C (2015)	1
CHEK1	2	TP53	0	affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study	Tian H (2002), Sengupta S (2004), Tian H (2002), Goudelock DM (2003), Shieh SY (2000)	5
RPA2	0	POLA1	0	affinity chromatography technology	Marechal A (2014)	1
POLE	10	GINS4	0	pull down	Bermudez VP (2011)	1
RPA1	0	PPP2CA	7	affinity chromatography technology	Marechal A (2014)	1
RPA2	0	PPP2CA	7	affinity chromatography technology	Marechal A (2014)	1
NTRK1	1	MCM2	3	affinity chromatography technology	Emdal KB (2015)	1
PURA	23	RB1	2	pull down, affinity chromatography technology	Johnson EM (1995), Johnson EM (1995)	2
POLA1	0	PRIM2	1	biochemical, biochemical, biochemical, biochemical	Kilkenny ML (2012), Kilkenny ML (2012), Havugimana PC (2012), Kristensen AR (2012)	4
HUS1	1	RPA3	2	genetic interference	Horlbeck MA (2018)	1
CHEK1	2	RB1	2	enzymatic study, pull down	Inoue Y (2007), Inoue Y (2007)	2
CDC6	0	MYC	2	pull down	Takayama M (2000)	1
RPA3	2	EMG1	1	affinity chromatography technology	Marechal A (2014)	1
POLA1	0	GINS4	0	pull down	Bermudez VP (2011)	1
HUS1	1	RPA1	0	affinity chromatography technology, affinity chromatography technology	Wu X (2005), Wu X (2005)	2
POLA1	0	RPL36A	0	genetic interference	Horlbeck MA (2018)	1
SIRT7	1	MRE11	3	affinity chromatography technology	Tsai YC (2012)	1
SHMT2	3	POLA1	0	affinity chromatography technology	Castello A (2012)	1
NTRK1	1	RPA1	0	affinity chromatography technology	Emdal KB (2015)	1
NXF1	0	PARP1	3	affinity chromatography technology	Castello A (2012)	1
NTRK1	1	CDC45	1	affinity chromatography technology	Emdal KB (2015)	1
POLA2	2	PRIM1	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
CDK2	0	TP53	0	enzymatic study, enzymatic study, imaging technique	Luciani MG (2000), Tsai CH (2009), Chen TC (2014)	3
MCM3	2	CCNE1	1	affinity chromatography technology, pull down	Li J (2011), Li J (2011)	2
CDC45	1	CDK2	0	affinity chromatography technology, affinity chromatography technology	Alexandrow MG (2005), Alexandrow MG (2005)	2
CDK2	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koundrioukoff S (2000), Zhang H (1993), Neganova I (2011), Wu SM (1998), Chen Z (2002), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
TRIM25	5	POLA1	0	affinity chromatography technology	Choudhury NR (2017)	1
SIRT7	1	POLE	10	affinity chromatography technology	Tsai YC (2012)	1
NXF1	0	RAE1	0	affinity chromatography technology, affinity chromatography technology	Bachi A (2000), Bachi A (2000)	2
MOV10	6	PARP1	3	affinity chromatography technology	Castello A (2012)	1
NTRK1	1	UBA2	0	affinity chromatography technology	Emdal KB (2015)	1
MMS19	5	POLE	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stehling O (2012), Moiseeva TN (2016), Moiseeva TN (2016)	3
PPP2CA	7	PPP2R1B	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Sablina AA (2007), Sablina AA (2007), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Yadav L (2017)	10
CDK2	0	CDK1	0	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Huttlin EL (2017)	2
MOV10	6	POLA1	0	affinity chromatography technology	Castello A (2012)	1
RPA3	2	PARP1	3	affinity chromatography technology	Marechal A (2014)	1
TRIM25	5	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
RPA2	0	MOV10	6	affinity chromatography technology	Marechal A (2014)	1
POLA1	0	MCM3	2	biochemical	Havugimana PC (2012)	1
TRIM25	5	RPA1	0	affinity chromatography technology	Pauli EK (2014)	1
CIAO1	3	PRIM2	1	affinity chromatography technology	Stehling O (2013)	1
EMG1	1	POLA1	0	genetic interference	Horlbeck MA (2018)	1
NTRK1	1	WDHD1	4	affinity chromatography technology	Emdal KB (2015)	1
UBA2	0	CHEK1	2	pull down	Tan X (2015)	1
MCM2	3	SMC1A	15	affinity chromatography technology	Boldt K (2016)	1
PPP2CA	7	TP53	0	affinity chromatography technology	Shouse GP (2011)	1
RPA2	0	MRE11	3	affinity chromatography technology	Marechal A (2014)	1
RPA3	2	MOV10	6	affinity chromatography technology	Marechal A (2014)	1
NTRK1	1	PURA	23	affinity chromatography technology	Emdal KB (2015)	1
CCNE1	1	MRE11	3	affinity chromatography technology	Stewart GS (2003)	1
PARP1	3	PCNA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Frouin I (2003), Cazzalini O (2010), Cazzalini O (2010), Lee CH (2010), Pozo FM (2011), Sekimoto T (2010)	6
CCNA2	1	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Amador V (2007), Horton LE (1997), Lin ML (2011), Lin ML (2011), OConnor PM (1993), Varjosalo M (2013), Kikuchi R (2014), Mateo F (2009), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	13
RPA1	0	PRIM1	1	affinity chromatography technology	Olson E (2006)	1
MBTPS2	1	POLA1	0	genetic interference	Horlbeck MA (2018)	1
CHEK1	2	CDC6	0	genetic interference	Srivas R (2016)	1
EIF4G2	7	EMG1	1	genetic interference	Horlbeck MA (2018)	1
MCM3	2	CDC45	1	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Mulvaney KM (2016)	3
SIRT7	1	TP53	0	affinity chromatography technology	Tsai YC (2012)	1
MCM3	2	GINS4	0	biochemical	Wan C (2015)	1
RPA1	0	POLA1	0	affinity chromatography technology	Marechal A (2014)	1
PCNA	0	POLE	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Ohta S (2002), Ogi T (2010), Han J (2014), Wan C (2015), Boehm EM (2016)	5
RPA2	0	PRIM1	1	affinity chromatography technology, biochemical	Olson E (2006), Wan C (2015)	2
PCNA	0	CDC45	1	biochemical	Wan C (2015)	1
NTRK1	1	MMS19	5	affinity chromatography technology	Emdal KB (2015)	1
MYC	2	NTRK1	1	genetic interference	Toyoshima M (2012)	1
NTRK1	1	ENO1	3	affinity chromatography technology	Emdal KB (2015)	1
STN1	0	POLA1	0	affinity chromatography technology	Huttlin EL (2015)	1
SIRT7	1	POLA1	0	affinity chromatography technology	Tsai YC (2012)	1
RPA1	0	PARP1	3	affinity chromatography technology	Marechal A (2014)	1
NXF1	0	POLA1	0	affinity chromatography technology	Castello A (2012)	1
POLA2	2	PRIM2	1	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
CIAO1	3	PRIM1	1	affinity chromatography technology	Stehling O (2013)	1
TRIM25	5	PCNA	0	affinity chromatography technology, affinity chromatography technology	Park JM (2014), Park JM (2014)	2
MCM3	2	CDK2	0	affinity chromatography technology, pull down, pull down	Li J (2011), Li J (2011), Ramachandran N (2004)	3
MYC	2	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PCNA	0	RPA1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ohta S (2002), Ogi T (2010), Takasaki Y (2001), Gong Z (2011), Miccoli L (2005), Han J (2014)	6
ALDH1L2	1	POLA1	0	affinity chromatography technology	Huttlin EL (2015)	1
POLA1	0	PARP1	3	affinity chromatography technology, far western blotting	Dantzer F (1998), Dantzer F (1998)	2
RPA2	0	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Huttlin EL (2015), Huttlin EL (2017)	3
PARP1	3	TP53	0	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, pull down, pull down	Gueven N (2004), Malanga M (1998), Vaziri H (1997), Vaziri H (1997), Wesierska-Gadek J (2003), Simbulan-Rosenthal CM (2003)	6
POLE4	0	POLE	10	biochemical, affinity chromatography technology	Wan C (2015), Moiseeva TN (2016)	2
SIRT7	1	NXF1	0	affinity chromatography technology	Tsai YC (2012)	1
TFDP3	0	RB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK2	0	MCM2	3	enzymatic study, affinity chromatography technology	Montagnoli A (2006), Neganova I (2011)	2
PCNA	0	RPA3	2	affinity chromatography technology	Takasaki Y (2001)	1
NTRK1	1	POLA1	0	affinity chromatography technology	Emdal KB (2015)	1
MMS19	5	POLA2	2	affinity chromatography technology	Stehling O (2012)	1
CDK2AP1	1	POLA1	0	pull down	Matsuo K (2000)	1
POLA1	0	TP53	0	affinity chromatography technology	Melle C (2002)	1
POLA1	0	CCNA2	1	affinity chromatography technology, enzymatic study	Dehde S (2001), Dehde S (2001)	2
NTRK1	1	RB1	2	affinity chromatography technology	Emdal KB (2015)	1
POLA1	0	POLE4	0	biochemical	Wan C (2015)	1
HUS1	1	PCNA	0	two hybrid, two hybrid, affinity chromatography technology	Komatsu K (2000), Komatsu K (2000), Komatsu K (2000)	3
POLA1	0	CDC45	1	pull down	Kukimoto I (1999)	1
CCNB1	3	POLA1	0	enzymatic study	Dehde S (2001)	1
CDK2	0	SMC1A	15	affinity chromatography technology	Neganova I (2011)	1
CDK1	0	CDC6	0	enzymatic study	Jiang W (1999)	1
RPA2	0	MCM3	2	two hybrid, biochemical	Kneissl M (2003), Havugimana PC (2012)	2
POLA1	0	RBMS1	1	two hybrid, affinity chromatography technology, pull down, genetic interference	Niki T (2000), Niki T (2000), Niki T (2000), Niki T (2000)	4
POLA1	0	POLE	10	biochemical	Wan C (2015)	1
POLD3	0	PCNA	0	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, unspecified method, two hybrid, far western blotting, fluorescent resonance energy transfe, affinity chromatography technology	Ducoux M (2001), Ohta S (2002), Pohler JR (2005), Shikata K (2001), Shikata K (2001), Bruning JB (2004), Plosky BS (2006), Li H (2006), Nicolae CM (2014), Hein MY (2015)	10
NTRK1	1	POLE	10	affinity chromatography technology	Emdal KB (2015)	1
POLA1	0	PURA	23	biochemical	Havugimana PC (2012)	1
CCNE1	1	CDK1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Koff A (1992), Koff A (1992), Horton LE (1997)	4
RPA1	0	SMC1A	15	affinity chromatography technology	Marechal A (2014)	1
NXF1	0	PRIM1	1	affinity chromatography technology	Castello A (2012)	1
RPA1	0	MCM2	3	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Drissi R (2015)	3
HUS1	1	POLD3	0	genetic interference	Horlbeck MA (2018)	1
TP53	0	MOV10	6	affinity chromatography technology	Li X (2015)	1
RB1	2	TP53	0	affinity chromatography technology, pull down	Delston RB (2011), Sommer MH (1994)	2
NTRK1	1	LIG1	4	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	CDK1	0	affinity chromatography technology	Choudhury NR (2017)	1
CDK2	0	RPA1	0	enzymatic study	Pan ZQ (1993)	1
MYC	2	CDK2	0	genetic interference, genetic interference	Toyoshima M (2012), Zhou Z (2014)	2
KRAS	1	CCNA2	1	genetic interference	Luo J (2009)	1
MOV10	6	PRIM1	1	affinity chromatography technology	Castello A (2012)	1
NTRK1	1	XRCC5	5	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CDK2	0	affinity chromatography technology	Emdal KB (2015)	1
TFDP3	0	POLA1	0	affinity chromatography technology	Huttlin EL (2015)	1
CDK1	0	CHEK1	2	affinity chromatography technology	Hein MY (2015)	1
POLD3	0	MCM3	2	biochemical	Havugimana PC (2012)	1
TP53	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Banks D (2006), Banks D (2006), Hampp S (2016), Hampp S (2016)	4
CIAO1	3	POLE	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stehling O (2013), Moiseeva TN (2016), Moiseeva TN (2016)	3
HUS1	1	UBA2	0	genetic interference	Horlbeck MA (2018)	1
MYC	2	POLE	10	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Koch HB (2007)	2
MCM3	2	UBA2	0	genetic interference	Horlbeck MA (2018)	1
STN1	0	PRIM1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HELB	1	POLA1	0	pull down	Taneja P (2002)	1
KRAS	1	NXF1	0	genetic interference	Luo J (2009)	1
RPA3	2	WDHD1	4	affinity chromatography technology	Marechal A (2014)	1
NTRK1	1	EIF4G2	7	affinity chromatography technology	Emdal KB (2015)	1
CDC6	0	MCM3	2	affinity chromatography technology, biochemical, pull down	Fujita M (1999), Mendez J (2000), Ramachandran N (2004)	3
CHEK1	2	POLA1	0	affinity chromatography technology	Taricani L (2009)	1
PCNA	0	RPA2	0	affinity chromatography technology	Takasaki Y (2001)	1
HUS1	1	PRIM2	1	genetic interference	Horlbeck MA (2018)	1
ENO1	3	POLA1	0	affinity chromatography technology	Castello A (2012)	1
RB1	2	MYC	2	two hybrid, fluorescent resonance energy transfe	Adnane J (1995), Ivanov AA (2017)	2
RPA3	2	RPA1	0	biochemical, x-ray crystallography, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Du Y (2009), Wan C (2015), Hein MY (2015), Elia AE (2015)	8
NTRK1	1	PRIM2	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	PARP1	3	affinity chromatography technology	Emdal KB (2015)	1
PRIM1	1	PRIM2	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
EIF4G2	7	POLA1	0	genetic interference	Horlbeck MA (2018)	1
RPA3	2	POLA1	0	affinity chromatography technology	Marechal A (2014)	1
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
LIG1	4	MRE11	3	two hybrid	Petrini JH (1995)	1
SMC1A	15	POLE	10	biochemical	Wan C (2015)	1
CDK1	0	TP53	0	enzymatic study, affinity chromatography technology	Luciani MG (2000), Ababneh M (2001)	2
CIAO1	3	POLA1	0	affinity chromatography technology	Stehling O (2013)	1
RPA3	2	RPL36A	0	genetic interference	Horlbeck MA (2018)	1
RPA2	0	EMG1	1	affinity chromatography technology	Marechal A (2014)	1
POLA2	2	POLA1	0	pull down, biochemical, biochemical, biochemical	Collins KL (1993), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
CCNB1	3	RB1	2	enzymatic study, enzymatic study	Jiang W (1998), Knudsen ES (1997)	2
RPA1	0	MOV10	6	affinity chromatography technology	Marechal A (2014)	1
MOV10	6	LIG1	4	affinity chromatography technology	Castello A (2012)	1
MMS19	5	PRIM2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stehling O (2012), Gari K (2012), Gari K (2012)	3
CDK2	0	ENO1	3	affinity chromatography technology	Neganova I (2011)	1
RAE1	0	SMC1A	15	affinity chromatography technology, affinity chromatography technology	Wong RW (2008), Wong RW (2008)	2
MYC	2	XRCC5	5	affinity chromatography technology	Koch HB (2007)	1
CCNE1	1	CDC6	0	enzymatic study	Jiang W (1999)	1
CDK2	0	POLA1	0	enzymatic study, affinity chromatography technology, enzymatic study	Matsuo K (2000), Dehde S (2001), Dehde S (2001)	3
HUS1	1	POLE	10	genetic interference	Horlbeck MA (2018)	1
POLA1	0	UBA2	0	genetic interference	Horlbeck MA (2018)	1
MYC	2	PPP2CA	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Arnold HK (2009), Junttila MR (2007), Cianfanelli V (2015), Cianfanelli V (2015)	4
MRE11	3	POLA1	0	genetic interference	van Pel DM (2013)	1
KRAS	1	RPA2	0	genetic interference	Luo J (2009)	1
SMC1A	15	POLA1	0	affinity chromatography technology	Ryu MJ (2006)	1
MRE11	3	MCM2	3	genetic interference	van Pel DM (2013)	1
XRCC5	5	PRIM1	1	affinity chromatography technology	Matheos D (2002)	1
MCM2	3	EIF4G2	7	affinity chromatography technology	Drissi R (2015)	1
HUS1	1	RPA2	0	affinity chromatography technology	Wu X (2005)	1
RPA3	2	PRIM1	1	affinity chromatography technology	Olson E (2006)	1
CHEK1	2	PARP1	3	genetic interference	Shen JP (2017)	1
CCNB1	3	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Yang Q (2000), Pines J (1989), Kong M (2000), Amador V (2007), Paulsen MT (2006), Niida H (2005), Pereg Y (2010), Tamura D (2010), Kiviharju-af Haellstroem TM (2007), Pan ZQ (1993), Pan ZQ (1993), Pan ZQ (1993), van Zon W (2010), Desai D (1995), Vazquez-Novelle MD (2010), Smith EM (2008), Poon RY (1996), OConnor PM (1993), Fosbrink M (2009), Linares JF (2011), Varjosalo M (2013), Felzien LK (1998), Toby GG (2003), So J (2015), Huttlin EL (2015), Wan C (2015), Jenkins RH (2014), Hein MY (2015), Hein MY (2015), Voets E (2015), Lin Z (2015), Lin Z (2015), Huttlin EL (2017)	34
CDK1	0	POLA1	0	enzymatic study	Dehde S (2001)	1
CCNA2	1	TP53	0	pull down	Luciani MG (2000)	1
CDK1	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Horton LE (1997), Lees JA (1991), Knudsen ES (1996), Jiang W (1998), De Luca A (1997), Chen Z (2002), Knudsen ES (1997), Pan W (2001)	8
RPA1	0	MCM3	2	affinity chromatography technology	Gong Z (2011)	1
SIRT7	1	XRCC5	5	affinity chromatography technology	Tsai YC (2012)	1
TP53	0	RAE1	0	affinity chromatography technology	Fogeron ML (2013)	1
CCNB1	3	RPA1	0	enzymatic study	Pan ZQ (1993)	1
CCNA2	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Naderi S (2005), Varshochi R (2005), Di Fiore B (2010), Mateo F (2009), Abbas T (2007), Schulman BA (1998), Datta NS (1998), Wu G (1997), Sebastian B (1993), Liu S (2009), Ciarallo S (2002), Wolthuis R (2008), Vicent GP (2011), Zhang H (1995), Sayle KL (2003), Jeffrey PD (1995), Davies TG (2001), Cook A (2002), Pevarello P (2006), Levkau B (1998), Poon RY (1996), OConnor PM (1993), Davies TG (2002), Kontopidis G (2003), Andrews MJ (2004), Pevarello P (2004), Pevarello P (2005), Varjosalo M (2013), Varjosalo M (2013), Kikuchi R (2014), Kikuchi R (2014), Mateo F (2009), So J (2015), Okamoto K (2002), Song MS (2011), Huttlin EL (2015), Di Fiore B (2015), Pan ZQ (1993), Pan ZQ (1993), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	43
RPA2	0	SMC1A	15	affinity chromatography technology	Marechal A (2014)	1
MRE11	3	CDC45	1	genetic interference	van Pel DM (2013)	1
MYC	2	POLA1	0	genetic interference	Toyoshima M (2012)	1
POLA1	0	CCNE1	1	affinity chromatography technology	Dehde S (2001)	1
RPA3	2	MCM2	3	two hybrid	Kneissl M (2003)	1
NTRK1	1	MRE11	3	affinity chromatography technology	Emdal KB (2015)	1
MCM2	3	MMS19	5	affinity chromatography technology	Drissi R (2015)	1
XRCC5	5	POLA1	0	affinity chromatography technology	Matheos D (2002)	1
RAE1	0	POLA2	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015)	2
RPA2	0	MCM2	3	two hybrid	Kneissl M (2003)	1
POLA1	0	RB1	2	affinity chromatography technology, biochemical	Takemura M (1997), Takemura M (1997)	2
POLE	10	PRIM1	1	biochemical	Havugimana PC (2012)	1
CDC6	0	MCM2	3	pull down, affinity chromatography technology	Ramachandran N (2004), Hubbi ME (2013)	2
PCNA	0	CCNE1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLA1	0	MCM2	3	affinity chromatography technology	Dehde S (2001)	1
CDK1	0	RPA1	0	enzymatic study, enzymatic study	Pan ZQ (1993), Pan ZQ (1993)	2
RPA2	0	WDHD1	4	affinity chromatography technology	Marechal A (2014)	1
POLA1	0	LIG1	4	biochemical	Wan C (2015)	1
TRIM25	5	ENO1	3	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
NTRK1	1	PPP2CA	7	affinity chromatography technology	Emdal KB (2015)	1
SKAP1	0	POLA1	0	affinity chromatography technology	Huttlin EL (2015)	1
RPA3	2	UBA2	0	genetic interference	Horlbeck MA (2018)	1
CDK2	0	XRCC5	5	affinity chromatography technology	Neganova I (2011)	1
CDC6	0	CCNA2	1	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Petersen BO (1999), Petersen BO (1999), Saha P (1998), Jiang W (1999)	4
NTRK1	1	PCNA	0	affinity chromatography technology	Emdal KB (2015)	1
RPA3	2	XRCC5	5	affinity chromatography technology	Marechal A (2014)	1
RPA3	2	MRE11	3	affinity chromatography technology	Marechal A (2014)	1
CIAO1	3	POLA2	2	affinity chromatography technology	Stehling O (2013)	1
RPA3	2	SMC1A	15	affinity chromatography technology	Marechal A (2014)	1
CIAO1	3	MRE11	3	affinity chromatography technology	Stehling O (2013)	1
SOCS6	0	POLA1	0	affinity chromatography technology	Huttlin EL (2015)	1
RPA1	0	EMG1	1	affinity chromatography technology	Marechal A (2014)	1
RPA2	0	XRCC5	5	affinity chromatography technology	Marechal A (2014)	1
PPP2R1B	4	MCM3	2	affinity chromatography technology	Sablina AA (2007)	1
CCNA2	1	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Huttlin EL (2015), Huttlin EL (2017)	3
CIAO1	3	MMS19	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology	Havugimana PC (2012), Stehling O (2012), Stehling O (2012), Lev I (2013), Stehling O (2013), Stehling O (2013), Rolland T (2014), Gari K (2012), Gari K (2012), Gari K (2012), Huttlin EL (2015), Wan C (2015), Yu H (2011), Huttlin EL (2017)	14
RABL2A	0	POLA1	0	affinity chromatography technology	Huttlin EL (2015)	1
CDC6	0	POLA1	0	biochemical	Wan C (2015)	1
PRIM2	1	UBA2	0	genetic interference	Horlbeck MA (2018)	1
RAE1	0	PRIM2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
CCNE1	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McKenzie PP (2003), Shanahan F (1999), Koff A (1992), Koff A (1992), Mayer C (2004), Connor MK (2003), Boudrez A (2000), Varshochi R (2005), Jeong JH (2010), Bustany S (2011), Yeh ES (2006), Hui S (2011), Kim J (2007), Kiviharju-af Haellstroem TM (2007), Abbas T (2007), Nishimura T (2005), Matsumoto Y (2004), Harwell RM (2004), Harwell RM (2004), Peiretti A (2003), Peiretti A (2003), Kim YB (2000), Manenti S (1999), Datta NS (1998), Sheaff RJ (1997), Higashi H (1996), Higashi H (1996), Musgrove EA (1996), Vlach J (1996), Grim JE (2008), Liu S (2009), Ciarallo S (2002), Desai D (1995), Baydoun HH (2010), Baydoun HH (2010), Chu I (2007), Chu I (2007), Levkau B (1998), Poon RY (1996), Zhao J (1998), Zhao J (1998), Larrea MD (2009), Varjosalo M (2013), Varjosalo M (2013), Chan HM (2001), So J (2015), Ungermannova D (2005), Song MS (2011), Huttlin EL (2015), Hein MY (2015), Lin CH (2015), Lin CH (2015), Davis RJ (2017), Huttlin EL (2017)	54
PCNA	0	CDC6	0	two hybrid	Saha P (1998)	1
NTRK1	1	MOV10	6	affinity chromatography technology	Emdal KB (2015)	1
PPP2CA	7	CDK2	0	biochemical, enzymatic study, enzymatic study	Cheng A (2000), Cheng A (2000), Cheng A (2005)	3