PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBC	7	HNRNPA3	0	affinity chromatography technology	Matsumoto M (2005)	1
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
UBC	7	USP3	1	affinity chromatography technology, enzymatic study, pull down, pull down	Nicassio F (2007), Sloper-Mould KE (1999), Zhang X (2017), Kwasna D (2018)	4
TXLNG	1	CDV3	1	biochemical	Wan C (2015)	1
USP3	1	ZFAND6	0	biochemical	Havugimana PC (2012)	1
CDC34	3	ZFAND6	0	two hybrid	Duan W (2000)	1
ZFAND6	0	HNRNPA3	0	biochemical	Wan C (2015)	1
ZFAND6	0	NONO	3	biochemical	Wan C (2015)	1
TRAF5	1	TRAF2	1	affinity chromatography technology, pull down, pull down	Li S (2011), Li S (2011), Pullen SS (1998)	3
TRAF5	1	ZFAND6	0	two hybrid	Rolland T (2014)	1
ZFAND6	0	CIRBP	1	biochemical	Wan C (2015)	1
TRAF2	1	ZFAND6	0	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Chang EJ (2011), Chang EJ (2011), Chang EJ (2011), Huttlin EL (2017)	5
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
TRAF5	1	UBC	7	enzymatic study	Middleton AJ (2017)	1
PPP2R1A	8	ZFAND6	0	affinity chromatography technology	Fogeron ML (2013)	1
ZFAND6	0	GSS	0	biochemical	Wan C (2015)	1
ZFAND6	0	CDV3	1	biochemical	Wan C (2015)	1
ZFAND6	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
ZFAND6	0	TXLNG	1	biochemical	Wan C (2015)	1
TXLNG	1	USP3	1	biochemical	Havugimana PC (2012)	1
UBC	7	PPP2R1A	8	affinity chromatography technology	Matsumoto M (2005)	1
NONO	3	HNRNPA3	0	biochemical	Wan C (2015)	1
CDC34	3	UBC	7	pull down, x-ray crystallography, enzymatic study, enzymatic study, x-ray crystallography, pull down, fluorescent resonance energy transfe, affinity chromatography technology, enzymatic study, enzymatic study	Choi YS (2010), Choi YS (2010), Sheng Y (2012), Enchev RI (2012), Huang H (2014), Huang H (2014), Huang H (2014), Bish RA (2007), Chong RA (2014), Phillips AH (2013)	10
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
UBC	7	ZFAND6	0	pull down, affinity chromatography technology, pull down, pull down	Fenner BJ (2009), Fenner BJ (2009), Nathan JA (2013), Zhang X (2017)	4
WIPI2	5	ZFAND6	0	biochemical	Havugimana PC (2012)	1