Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
TOLLIP	rs3750920	TT	acetylcysteine	efficacy	yes	Clinical endpoints included death, transplant, hospitalization, or FVC decline, and risk was adjusted for age, sex, prednisone use, azathioprine use, FVC, diffusion capacity of the lung, and trial/center.	Genotype TT is associated with increased response to acetylcysteine in people with Pulmonary Fibrosis as compared to genotypes CC + CT.	26331942	1447982629
TOLLIP	rs5743854	CC	acetylcysteine	efficacy	no	Clinical endpoints included death, transplant, hospitalization, or FVC decline, and risk was adjusted for age, sex, prednisone use, azathioprine use, FVC, diffusion capacity of the lung, and trial/center. Alleles given on reverse strand A and G.	Genotype CC is not associated with response to acetylcysteine in people with Pulmonary Fibrosis as compared to genotypes CG + GG.	26331942	1447982696
TOLLIP	rs5743890	TT	acetylcysteine	efficacy	no	Clinical endpoints included death, transplant, hospitalization, or FVC decline, and risk was adjusted for age, sex, prednisone use, azathioprine use, FVC, diffusion capacity of the lung, and trial/center. Alleles given on reverse strand A and G.	Genotype TT is not associated with response to acetylcysteine in people with Pulmonary Fibrosis as compared to genotypes CC + CT.	26331942	1447982682
TOLLIP	rs5743894	TT	acetylcysteine	efficacy	no	Clinical endpoints included death, transplant, hospitalization, or FVC decline, and risk was adjusted for age, sex, prednisone use, azathioprine use, FVC, diffusion capacity of the lung, and trial/center. Alleles given on reverse strand A and G.	Genotype TT is not associated with response to acetylcysteine in people with Pulmonary Fibrosis as compared to genotypes CC + CT.	26331942	1447982668