PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VDR	2	CREBBP	29	imaging technique, pull down	Saramaeki A (2006), Jimenez-Lara AM (1999)	2
POU1F1	2	NCOR1	9	affinity chromatography technology, affinity chromatography technology, pull down	Voss TC (2005), Xu L (1998), Xu L (1998)	3
NCOR1	9	VDR	2	pull down, two hybrid, two hybrid, pull down, two hybrid, pull down, pull down	Puccetti E (2002), Tagami T (1998), Kim JY (2009), Kim JY (2009), Polly P (2000), Herdick M (2000), Herdick M (2000)	7
PPARG	0	CREBBP	29	pull down, two hybrid, unspecified method, pull down, two hybrid, pull down, unspecified method	Li M (2000), Chen Q (2004), Lee G (2002), Carmona MC (2007), Carmona MC (2007), Jeninga EH (2007), Koppen A (2009)	7
NR3C1	2	CREBBP	29	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Almloef T (1998), Almloef T (1998), Fryer CJ (1998), Govindan MV (2010), Govindan MV (2010), Govindan MV (2010), Carruthers CW (2015)	7
NR3C1	2	JUN	0	pull down	Lerner L (2003)	1
PPARG	0	MED1	4	fluorescent resonance energy transfe, pull down, two hybrid, pull down, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, unspecified method, pull down, pull down, two hybrid, unspecified method	Iannone MA (2001), Yang W (2000), Shao G (2000), Treuter E (1999), Albers M (2005), Feige JN (2007), Feige JN (2007), Qin C (2004), Lee G (2002), Agostini M (2006), Carmona MC (2007), Carmona MC (2007), Koppen A (2009)	13
PPARA	1	NCOR1	9	two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Dowell P (1999), Dowell P (1999), Ki SH (2005), Liu MH (2008), Pourcet B (2010), Krogsdam AM (2002)	6
KIF5B	1	NCOR1	9	affinity chromatography technology	Hein MY (2015)	1
POU1F1	2	NR1I2	5	pull down	Gonzalez MM (2002)	1
PPARG	0	VDR	2	pull down, affinity chromatography technology	Alimirah F (2012), Alimirah F (2012)	2
POU1F1	2	MED1	4	pull down, affinity chromatography technology	Gordon DF (2006), Gordon DF (2006)	2
JUN	0	NCOR1	9	imaging technique	Subbaramaiah K (2007)	1
POU1F1	2	VDR	2	pull down	Gonzalez MM (2002)	1
POU1F1	2	NR1I3	2	pull down	Gonzalez MM (2002)	1
POU1F1	2	NR3C1	2	pull down	Nalda AM (1997)	1
VDR	2	MED1	4	affinity chromatography technology, imaging technique, imaging technique, pull down, pull down, affinity chromatography technology, pull down, pull down, two hybrid	Ito M (1999), Saramaeki A (2006), Vaeisaenen S (2005), Rachez C (2000), Carvallo L (2008), Rachez C (1999), Rachez C (1999), Yamamoto H (2003), Yamamoto H (2003)	9
NCOR1	9	PPARG	0	two hybrid, imaging technique, imaging technique, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, unspecified method, pull down, pull down, pull down, unspecified method	Pascual G (2005), Guan HP (2005), Guan HP (2005), Feige JN (2007), Feige JN (2007), Li P (2011), Li P (2011), Song K (2013), Lee G (2002), Lee G (2002), Krogsdam AM (2002), Krogsdam AM (2002), Koppen A (2009)	13
POU1F1	2	CREBBP	29	affinity chromatography technology, pull down	Xu L (1998), Xu L (1998)	2
CEBPD	0	CREBBP	29	pull down	Kovacs KA (2003)	1
PPARG	0	JUN	0	unspecified method	Lee G (2002)	1
KIF5B	1	POU1F1	2	affinity chromatography technology	Hein MY (2015)	1
POU1F1	2	PPARA	1	pull down	Gonzalez MM (2002)	1
GATA2	0	MED1	4	pull down, affinity chromatography technology	Gordon DF (2006), Gordon DF (2006)	2
NR3C1	2	MED1	4	pull down, pull down, bioid	Zilliacus J (2001), Hittelman AB (1999), Lempiaeinen JK (2017)	3
NR1I3	2	MED1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POU1F1	2	PPARG	0	pull down	Gonzalez MM (2002)	1
NCOR1	9	CREBBP	29	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Cowger JJ (2006), Cowger JJ (2006), Cowger JJ (2006), Cowger JJ (2006)	4
GATA2	0	JUN	0	pull down	Yamashita K (2001)	1
PITX1	2	POU1F1	2	two hybrid, pull down	Szeto DP (1996), Szeto DP (1996)	2
JUN	0	POU1F1	2	pull down	Farrow KN (1996)	1
VDR	2	JUN	0	pull down	Towers TL (1999)	1
POU1F1	2	GATA2	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Dasen JS (1999), Dasen JS (1999), Gordon DF (2006), Gordon DF (2006), Gordon DF (2006)	5
NR1I2	5	NCOR1	9	two hybrid, affinity chromatography technology	Li CW (2009), Li CW (2009)	2
POU1F1	2	CEBPD	0	affinity chromatography technology	Tong Y (2011)	1
NR3C1	2	NCOR1	9	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, bioid	Stevens A (2003), Schulz M (2002), Schulz M (2002), Ki SH (2005), Wang Q (2004), Wang Q (2004), Lempiaeinen JK (2017)	7
POU5F1	0	POU1F1	2	affinity chromatography technology	Oliviero G (2015)	1
NR3C1	2	PPARG	0	affinity chromatography technology	Nie M (2005)	1
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8