PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF41	2	IRS4	2	two hybrid	Wijesuriya TM (2017)	1
IRS4	2	MAGEL2	6	two hybrid	Wijesuriya TM (2017)	1
RNF41	2	MAGEL2	6	two hybrid	Wijesuriya TM (2017)	1
PCGF6	0	USP7	14	affinity chromatography technology	Huttlin EL (2017)	1
VPS26A	0	VPS35	2	biochemical, biochemical, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Harrison MS (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Zavodszky E (2014)	8
MAGEL2	6	PCGF6	0	two hybrid	Kozakova L (2015)	1
MAGEL2	6	USP7	14	affinity chromatography technology, bioid	Hao YH (2013), Wijesuriya TM (2017)	2
MAGEL2	6	VPS26A	0	affinity chromatography technology	Hao YH (2013)	1
IRS4	2	NDN	0	two hybrid	Wijesuriya TM (2017)	1
VPS52	0	RNF41	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, protein complementation assay, affinity chromatography technology, fluorescent resonance energy transfe	Rolland T (2014), Wijesuriya TM (2017), Masschaele D (2017), Masschaele D (2017), Masschaele D (2017), Masschaele D (2017), Masschaele D (2017), Lievens S (2016), Lievens S (2016), Lievens S (2016)	10
USP8	7	MAGEL2	6	two hybrid, bioid	Wijesuriya TM (2017), Wijesuriya TM (2017)	2
RNF41	2	USP8	7	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, fluorescent resonance energy transfe	Wu X (2004), Wu X (2004), Avvakumov GV (2006), Avvakumov GV (2006), Wijesuriya TM (2017), De Ceuninck L (2013), De Ceuninck L (2013), De Ceuninck L (2013)	8
VPS52	0	MAGEL2	6	two hybrid	Wijesuriya TM (2017)	1
USP7	14	TRIM27	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hayes SD (2012), Hein MY (2015), Zaman MM (2013), Zaman MM (2013)	4
TRIM27	2	MAGEL2	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Doyle JM (2010), Hao YH (2013), Hao YH (2013), Hao YH (2013), Wijesuriya TM (2017)	5
NDN	0	MAGEL2	6	bioid	Wijesuriya TM (2017)	1
MAGEL2	6	VPS35	2	affinity chromatography technology, affinity chromatography technology	Hao YH (2013), Hao YH (2013)	2