PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
NDFIP2	2	EGFR	5	affinity chromatography technology	Mund T (2010)	1
EGFR	5	LYN	2	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
NDFIP2	2	ITCH	1	affinity chromatography technology	Ohzono C (2010)	1
ELAVL1	0	PTEN	24	affinity chromatography technology	Abdelmohsen K (2009)	1
EGFR	5	ITCH	1	affinity chromatography technology	Tong J (2014)	1
ELAVL1	0	NDFIP2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
NEDD4L	3	NDFIP2	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, far western blotting	Persaud A (2009), Konstas AA (2002), Konstas AA (2002), Konstas AA (2002)	4
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
PTEN	24	EGFR	5	affinity chromatography technology	Zheng J (2016)	1
AQP2	0	NEDD4	2	affinity chromatography technology	Trimpert C (2017)	1
TRIM25	5	NEDD4L	3	affinity chromatography technology	Choudhury NR (2017)	1
SLC11A2	2	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Howitt J (2009), Howitt J (2009)	2
IL20RB	2	NDFIP2	2	affinity chromatography technology	Huttlin EL (2015)	1
SRC	2	LYN	2	unspecified method	Pirozzi G (1997)	1
NEDD4	2	PTEN	24	enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wang X (2008), Wang X (2008), Yim EK (2009), Chung S (2011), Wu Y (2013), Hong SW (2013), Hong SW (2013), Li N (2015), Li Z (2014), Chen Z (2016), Ahn Y (2008)	11
SDHA	2	ELAVL1	0	affinity chromatography technology	Malty RH (2017)	1
PTGFR	1	NDFIP2	2	affinity chromatography technology	Huttlin EL (2015)	1
FAM8A1	5	NDFIP2	2	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	NEDD4L	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	ITCH	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	LYN	2	affinity chromatography technology	Abdelmohsen K (2009)	1
IL2RG	0	NDFIP2	2	affinity chromatography technology	Huttlin EL (2015)	1
NDFIP2	2	LYN	2	affinity chromatography technology, pull down	Mund T (2010), Mund T (2010)	2
TMEM231	1	NDFIP2	2	affinity chromatography technology	Huttlin EL (2015)	1
AQP2	0	NDFIP2	2	two hybrid	Trimpert C (2017)	1
NEDD4	2	SRC	2	affinity chromatography technology, pull down, enzymatic study	Persaud A (2014), Persaud A (2014), Persaud A (2014)	3
PTEN	24	WWP2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study	Crockett DK (2005), Ahmed SF (2012), Wu Y (2013), Maddika S (2011), Maddika S (2011), Maddika S (2011), Bawa-Khalfe T (2016), Bawa-Khalfe T (2016), Bawa-Khalfe T (2016), Chen Z (2016), Chen Z (2016), Chen Z (2017)	12
NEDD4	2	IL2RG	0	affinity chromatography technology	Malarde V (2009)	1
NEDD4	2	FYN	1	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
ITCH	1	FYN	1	affinity chromatography technology, affinity chromatography technology, pull down	Yang C (2006), Yang C (2006), Yang C (2006)	3
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
NDFIP2	2	FYN	1	affinity chromatography technology	Mund T (2010)	1
NDFIP2	2	SRC	2	affinity chromatography technology	Mund T (2010)	1
SLC11A2	2	NDFIP2	2	affinity chromatography technology	Foot NJ (2008)	1
NDFIP2	2	PTEN	24	affinity chromatography technology	Mund T (2010)	1
TSPAN3	0	NDFIP2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NDFIP2	2	WWP2	7	affinity chromatography technology	Ohzono C (2010)	1
NDFIP2	2	NEDD4	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology	Cristillo AD (2003), Cristillo AD (2003), Shearwin-Whyatt LM (2004), Woelk T (2006), Ohzono C (2010), Persaud A (2009), Persaud A (2009), Konstas AA (2002)	8
NEDD4	2	EGFR	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
IL2RG	0	NEDD4L	3	affinity chromatography technology	Warren KJ (2016)	1
SDHA	2	NDFIP2	2	affinity chromatography technology	Malty RH (2017)	1
TRIM25	5	NDFIP2	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	LYN	2	affinity chromatography technology	Choudhury NR (2017)	1