PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK6	1	ALB	1	affinity chromatography technology	Huttlin EL (2017)	1
NR4A1	4	PPBP	2	two hybrid	Vinayagam A (2011)	1
COX17	0	PPBP	2	two hybrid	Stelzl U (2005)	1
PLEKHJ1	2	PPBP	2	two hybrid	Vinayagam A (2011)	1
MOB3B	0	PPBP	2	two hybrid	Vinayagam A (2011)	1
NDUFB11	0	PPBP	2	two hybrid	Vinayagam A (2011)	1
RAB10	1	PPBP	2	two hybrid	Vinayagam A (2011)	1
ALB	1	PPBP	2	affinity chromatography technology	Zhou M (2004)	1
RPS27	0	PPBP	2	two hybrid	Vinayagam A (2011)	1
COPS7A	0	PPBP	2	two hybrid	Stelzl U (2005)	1
EFNA1	0	PPBP	2	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
MAPK6	1	RPS27	0	affinity chromatography technology	Rodriguez J (2016)	1
MAPK6	1	PPBP	2	two hybrid	Vinayagam A (2011)	1
CMTM6	0	PPBP	2	two hybrid	Vinayagam A (2011)	1
COPG1	5	PPBP	2	two hybrid	Wang J (2011)	1
CELF1	0	PPBP	2	two hybrid	Stelzl U (2005)	1
PPBP	2	PPBP	2	x-ray crystallography	Yang Y (1994)	1