PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PHB	0	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi B (2003), Wang S (2002), Gamble SC (2007), He B (2008)	4
PALB2	3	BCAS3	4	two hybrid	Arroyo R (2015)	1
XPO1	8	BCAS3	4	affinity chromatography technology	Kirli K (2015)	1
HDAC1	4	ESR1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Kawai H (2003), Kawai H (2003), Varshochi R (2005), Varshochi R (2005), Kurtev V (2004), Liu XF (2004), Itoh Y (2007), Tarallo R (2011), Yoshimaru T (2013)	9
FBF1	2	SCLT1	1	bioid	Gupta GD (2015)	1
PTPN1	2	BCAS3	4	two hybrid	Arroyo R (2015)	1
WIPI2	5	C16orf70	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PELP1	3	HIST1H3A	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Choi YB (2004), Choi YB (2004), Choi YB (2004), Nair SS (2010), Nair SS (2010), Kashiwaya K (2010)	6
HNRNPL	3	CCND1	1	affinity chromatography technology	Fei T (2017)	1
KRAS	1	PTPN1	2	genetic interference	Luo J (2009)	1
KRAS	1	FBXW7	2	genetic interference	Luo J (2009)	1
KAT2B	2	CCND1	1	affinity chromatography technology	McMahon C (1999)	1
KRAS	1	XPO1	8	genetic interference	Luo J (2009)	1
SMAD4	9	IRF3	4	affinity chromatography technology	Qing J (2004)	1
KAT2B	2	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique, enzymatic study, enzymatic study	Brackertz M (2006), Seo SB (2002), Pasheva E (2004), Kouskouti A (2005), Kiernan RE (1999), Wong K (2005), Hoffmann A (2008), Shen M (2013), Yamaguchi Y (2004), Tropberger P (2013)	10
TSG101	1	BCAS3	4	two hybrid	Arroyo R (2015)	1
CTBP1	2	CDC23	3	two hybrid	Corominas R (2014)	1
TGFB1	2	BCAS3	4	two hybrid	Arroyo R (2015)	1
CTBP2	7	CTBP1	2	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sewalt RG (1999), Wang J (2011), Corominas R (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
BCAS3	4	PELP1	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Gururaj AE (2007), Gururaj AE (2007), Gururaj AE (2007), Gururaj AE (2007)	4
HDAC1	4	BCAS3	4	affinity chromatography technology	Hein MY (2015)	1
DOCK5	6	BCAS3	4	affinity chromatography technology	Huttlin EL (2017)	1
CCND1	1	XPO1	8	pull down	Connor MK (2003)	1
WIPI2	5	BCAS3	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZDHHC17	1	BCAS3	4	two hybrid	Butland SL (2014)	1
BAG4	2	BCAS3	4	two hybrid	Arroyo R (2015)	1
CEP128	1	BCAS3	4	bioid	Gupta GD (2015)	1
CTBP1	2	KAT2B	2	enzymatic study, affinity chromatography technology, pull down	Fuks F (1998), Senyuk V (2005), Kim JH (2005)	3
CEP128	1	SCLT1	1	bioid	Gupta GD (2015)	1
CDC23	3	BCAS3	4	two hybrid	Rolland T (2014)	1
KAT2B	2	CTBP2	7	affinity chromatography technology	Shimahara A (2010)	1
CEP128	1	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
XPO1	8	ESR1	0	affinity chromatography technology	Castoria G (2012)	1
HNRNPL	3	DOCK5	6	affinity chromatography technology	Fei T (2017)	1
ZDHHC17	1	KRAS	1	two hybrid	Butland SL (2014)	1
CTBP2	7	BCAS3	4	two hybrid	Rolland T (2014)	1
XPO1	8	IRF3	4	affinity chromatography technology	Kirli K (2015)	1
HNRNPL	3	CTBP1	2	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	CTBP2	7	affinity chromatography technology	Fei T (2017)	1
PHB	0	XPO1	8	affinity chromatography technology, affinity chromatography technology	Rastogi S (2006), Rastogi S (2006)	2
PTPN1	2	PHB	0	affinity chromatography technology	Hein MY (2015)	1
IL17RA	3	BCAS3	4	affinity chromatography technology	Huttlin EL (2017)	1
BCAS3	4	ESR1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gururaj AE (2007), Gururaj AE (2007), Gururaj AE (2007), Gururaj AE (2007)	4
CCND1	1	ESR1	0	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Zwijsen RM (1997), Zwijsen RM (1997), Zwijsen RM (1997), Wang C (2005), Wang C (2005)	5
CCND1	1	BCAS3	4	two hybrid	Arroyo R (2015)	1
HNRNPL	3	BCAS3	4	affinity chromatography technology	Fei T (2017)	1
ATM	9	BCAS3	4	two hybrid	Arroyo R (2015)	1
PHB	0	BCAS3	4	two hybrid	Arroyo R (2015)	1
HDAC1	4	CTBP1	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang CL (2001), Melhuish TA (2000), Sundqvist A (1998), Jin W (2008), Joshi P (2013)	5
CEP128	1	NPHP1	2	bioid	Gupta GD (2015)	1
RAB2B	0	BCAS3	4	affinity chromatography technology	Huttlin EL (2017)	1
IRF3	4	BCAS3	4	affinity chromatography technology	Li X (2015)	1
KRAS	1	BCAS3	4	two hybrid	Arroyo R (2015)	1
ATM	9	HDAC1	4	pull down, affinity chromatography technology	Kim GD (1999), Kim GD (1999)	2
FBF1	2	CTBP1	2	bioid	Gupta GD (2015)	1
CTBP1	2	BCAS3	4	two hybrid	Rolland T (2014)	1
VWA5A	2	BCAS3	4	affinity chromatography technology	Huttlin EL (2017)	1
FBXW7	2	BCAS3	4	two hybrid	Arroyo R (2015)	1
STK11	2	TSG101	1	two hybrid	Arroyo R (2015)	1
HIST1H3A	3	BCAS3	4	pull down, far western blotting, affinity chromatography technology	Gururaj AE (2007), Gururaj AE (2007), Gururaj AE (2007)	3
BCAS3	4	C16orf70	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
SMAD4	9	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
XPO1	8	CDC23	3	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	XRCC3	1	affinity chromatography technology	Kirli K (2015)	1
PALB2	3	XRCC3	1	pull down	Park JY (2014)	1
FBF1	2	OFD1	3	bioid	Gupta GD (2015)	1
PALB2	3	HIST1H3A	3	affinity chromatography technology	Bleuyard JY (2012)	1
CEP128	1	FBF1	2	bioid	Gupta GD (2015)	1
FBF1	2	BCAS3	4	bioid	Gupta GD (2015)	1
PELP1	3	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Vadlamudi RK (2001), Vadlamudi RK (2001), Barletta F (2004), Barletta F (2004), Tarallo R (2011)	5
NPHP1	2	BCAS3	4	bioid	Gupta GD (2015)	1
KRAS	1	PHB	0	affinity chromatography technology	Rajalingam K (2005)	1
OFD1	3	CTBP1	2	bioid	Gupta GD (2015)	1
CD14	3	BCAS3	4	affinity chromatography technology	Hein MY (2015)	1
STK11	2	BCAS3	4	two hybrid	Arroyo R (2015)	1
PHB	0	ESR1	0	pull down	He B (2008)	1
XRCC3	1	BCAS3	4	two hybrid	Arroyo R (2015)	1
BCAS3	4	KAT2B	2	affinity chromatography technology	Gururaj AE (2007)	1
MAGEE1	3	C16orf70	4	affinity chromatography technology	Huttlin EL (2017)	1
TSG101	1	XPO1	8	biochemical, affinity chromatography technology	Havugimana PC (2012), Kirli K (2015)	2
OFD1	3	BCAS3	4	bioid	Gupta GD (2015)	1
SCLT1	1	BCAS3	4	bioid	Gupta GD (2015)	1
HDAC1	4	CCND1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Fu M (2005), Fu M (2005), Batra S (2010)	3
SMAD4	9	BCAS3	4	two hybrid	Arroyo R (2015)	1
HIST1H3A	3	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology	Nishioka K (2002), Li X (2014), Hein MY (2015)	3
XPO1	8	SMAD4	9	affinity chromatography technology	Kirli K (2015)	1
MAGEE1	3	BCAS3	4	affinity chromatography technology	Huttlin EL (2017)	1