PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VDAC1	2	PPM1B	2	affinity chromatography technology	Malty RH (2017)	1
CER1	0	PPM1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXW11	2	PPM1A	1	affinity chromatography technology	Coyaud E (2015)	1
INTS14	5	VDAC1	2	affinity chromatography technology	Hein MY (2015)	1
SMURF1	4	SLC25A5	1	affinity chromatography technology	Xie Y (2013)	1
SMURF1	4	PRKCI	1	enzymatic study	Andrews PS (2010)	1
AKT1	1	ERBB3	3	affinity chromatography technology	Kim CK (2011)	1
HAO2	1	PPM1A	1	affinity chromatography technology	Huttlin EL (2017)	1
ARRB1	2	MAPK9	3	two hybrid, two hybrid	Wang J (2011), Rolland T (2014)	2
AKT1	1	NR4A1	4	affinity chromatography technology, enzymatic study	Pekarsky Y (2001), Pekarsky Y (2001)	2
ADAMTS12	2	PPM1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	TOR1AIP1	2	affinity chromatography technology	Tong J (2014)	1
DUSP22	1	HSD17B4	0	bioid	St-Denis N (2016)	1
ZDHHC11	2	PPM1A	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
PAK4	3	PPM1B	2	biochemical	Wan C (2015)	1
HNRNPD	3	HSD17B4	0	affinity chromatography technology	Hein MY (2015)	1
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
CHEK1	2	XRCC5	5	affinity chromatography technology	Goudelock DM (2003)	1
PPM1A	1	NAA10	9	biochemical	Wan C (2015)	1
CYLD	2	HNRNPD	3	affinity chromatography technology	Elliott PR (2016)	1
ALDH3B1	0	PPM1A	1	affinity chromatography technology	Huttlin EL (2017)	1
CERKL	1	PPM1B	2	affinity chromatography technology	Huttlin EL (2017)	1
ARRB1	2	XRCC5	5	affinity chromatography technology	Xiao K (2007)	1
ARRB2	5	NAA10	9	affinity chromatography technology	Xiao K (2007)	1
HIP1R	5	PPM1B	2	affinity chromatography technology	Huttlin EL (2017)	1
HSFY1	0	PPM1A	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
PAK1	2	ERBB2	6	affinity chromatography technology	Adam L (1998)	1
NR4A1	4	PPM1A	1	two hybrid	Wang J (2011)	1
AATK	6	PPM1A	1	two hybrid	Yao Z (2017)	1
ERBB4	5	PPM1A	1	two hybrid	Yao Z (2017)	1
VDAC1	2	SLC25A5	1	affinity chromatography technology	Malty RH (2017)	1
AKT1	1	PPM1A	1	imaging technique	Chen TC (2014)	1
NEDD1	1	PPM1A	1	affinity chromatography technology	Hein MY (2015)	1
PPM1A	1	PRKCA	7	enzymatic study	Chan PM (2008)	1
TECPR2	1	PPM1A	1	affinity chromatography technology	Huttlin EL (2017)	1
CYLD	2	AKT1	1	enzymatic study, affinity chromatography technology	Yang WL (2013), Yang WL (2013)	2
LMTK2	8	PPM1A	1	two hybrid	Yao Z (2017)	1
CYLD	2	PPM1B	2	affinity chromatography technology	Elliott PR (2016)	1
ARRB2	5	XRCC5	5	affinity chromatography technology	Xiao K (2007)	1
MAPK9	3	ARRB2	5	two hybrid, two hybrid	Venkatesan K (2009), Rolland T (2014)	2
PPM1A	1	INTS14	5	affinity chromatography technology	Huttlin EL (2015)	1
HIP1R	5	PPM1A	1	affinity chromatography technology	Huttlin EL (2017)	1
INTS14	5	RTEL1	9	affinity chromatography technology	Hein MY (2015)	1
FBXW11	2	KDR	4	two hybrid, affinity chromatography technology	Vinayagam A (2011), Shaik S (2012)	2
SMAD1	0	PPM1A	1	affinity chromatography technology	Chau JF (2012)	1
EGFR	5	SLFN11	1	affinity chromatography technology	Tong J (2014)	1
PPM1B	2	MAP4K5	3	biochemical	Wan C (2015)	1
AATK	6	HSPB1	2	affinity chromatography technology	So J (2015)	1
SOAT1	3	SLC25A5	1	affinity chromatography technology	Malty RH (2017)	1
UBE3D	0	PPM1A	1	affinity chromatography technology	Huttlin EL (2017)	1
VDAC1	2	PPM1A	1	affinity chromatography technology	Malty RH (2017)	1
PPM1A	1	RPLP0	1	two hybrid	Wang J (2011)	1
INSR	9	PRKAA1	2	affinity chromatography technology	Boutchueng-Djidjou M (2015)	1
RPLP0	1	QARS	1	biochemical	Kristensen AR (2012)	1
HNRNPD	3	PPM1A	1	affinity chromatography technology	Hein MY (2015)	1
MAPK9	3	AKT1	1	enzymatic study	Xiao L (2010)	1
PPM1A	1	RTEL1	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PIGS	1	SOAT1	3	affinity chromatography technology	Boldt K (2016)	1
EGFR	5	IGF1R	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morgillo F (2006), Riedemann J (2007), Riedemann J (2007)	3
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
EGFR	5	ARRB2	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
VDAC1	2	XRCC5	5	affinity chromatography technology	Malty RH (2017)	1
INPPL1	6	SLC25A5	1	affinity chromatography technology	Brehme M (2009)	1
CCL22	1	PPM1A	1	affinity chromatography technology	Huttlin EL (2017)	1
KDR	4	PPM1A	1	two hybrid	Yao Z (2017)	1
EGFR	5	PPM1A	1	affinity chromatography technology, two hybrid	Yao Z (2017), Yao Z (2017)	2
AKT1	1	ARRB2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Beaulieu JM (2008), Beaulieu JM (2008), Lodeiro M (2009), Luan B (2009)	4
EGFR	5	XRCC5	5	affinity chromatography technology	Tong J (2014)	1
EGFR	5	PAK4	3	affinity chromatography technology	Yao Z (2017)	1
SMURF1	4	MAP4K5	3	enzymatic study	Andrews PS (2010)	1
CHST10	3	PPM1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPM1A	1	CDC42BPB	16	enzymatic study	Chan PM (2008)	1
INSR	9	PPM1A	1	affinity chromatography technology	Yao Z (2017)	1
IGF1R	5	ARRB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Broussas M (2009), Girnita L (2005), Girnita L (2005), Zheng H (2012)	4
PAK1	2	PAK2	0	affinity chromatography technology	Varjosalo M (2013)	1
CYLD	2	QARS	1	affinity chromatography technology	Elliott PR (2016)	1
PPM1A	1	GCN1	6	affinity chromatography technology	St-Denis N (2016)	1
PPM1A	1	BCKDK	2	affinity chromatography technology	St-Denis N (2016)	1
GRM3	0	PPM1A	1	two hybrid, affinity chromatography technology	Flajolet M (2003), Flajolet M (2003)	2
ASB2	1	PPM1A	1	affinity chromatography technology	Andresen CA (2014)	1
COQ2	2	PPM1A	1	affinity chromatography technology	Malty RH (2017)	1
PPM1A	1	PAK4	3	affinity chromatography technology	St-Denis N (2016)	1
RNASE13	0	PPM1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	INPPL1	6	affinity chromatography technology, affinity chromatography technology	Pesesse X (2001), Sanada F (2009)	2
PRSS22	0	PPM1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRB1	2	PPM1B	2	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
PPM1A	1	IWS1	3	affinity chromatography technology	St-Denis N (2016)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
SOAT1	3	VDAC1	2	affinity chromatography technology	Malty RH (2017)	1
ARRB2	5	HNRNPD	3	affinity chromatography technology	Xiao K (2007)	1
FANCI	1	AKT1	1	affinity chromatography technology, affinity chromatography technology, pull down	Zhang X (2016), Zhang X (2016), Zhang X (2016)	3
EGFR	5	ARRB1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
SMURF1	4	PPM1A	1	affinity chromatography technology	Xie Y (2013)	1
ARRB1	2	PPM1A	1	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
ERBB4	5	PPM1B	2	two hybrid	Yao Z (2017)	1
ACTR5	1	PPM1A	1	affinity chromatography technology	Hein MY (2015)	1
PPM1A	1	HSDL2	0	affinity chromatography technology	St-Denis N (2016)	1
PPM1A	1	QARS	1	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	CHEK1	2	genetic interference	Shen JP (2017)	1
GATD1	1	PPM1A	1	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	HSPB1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study	Rane MJ (2001), Rane MJ (2001), Rane MJ (2001), Wu R (2007), Wu R (2007), Wu R (2007), Rane MJ (2003), Rane MJ (2003), Rane MJ (2003)	9
SOD1	0	PPM1B	2	affinity chromatography technology	Malty RH (2017)	1
SOD1	0	XRCC5	5	affinity chromatography technology	Malty RH (2017)	1
ARRB1	2	IGF1R	5	affinity chromatography technology, affinity chromatography technology	Girnita L (2005), Girnita L (2005)	2
INSR	9	ARRB2	5	affinity chromatography technology	Luan B (2009)	1
PPM1A	1	PAK1	2	enzymatic study	Chan PM (2008)	1
HSPB1	2	XRCC5	5	two hybrid, affinity chromatography technology	Katsogiannou M (2014), Katsogiannou M (2014)	2
EGFR	5	ERBB4	5	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Meijer IM (2013), Kiuchi T (2014), Kiuchi T (2014)	3
PPM1A	1	MAP4K5	3	biochemical	Wan C (2015)	1
PTK7	8	PPM1B	2	two hybrid	Yao Z (2017)	1
PIGS	1	PPM1A	1	affinity chromatography technology	Hein MY (2015)	1
HNRNPD	3	CHEK1	2	biochemical	Wan C (2015)	1
COQ2	2	PPM1B	2	affinity chromatography technology	Malty RH (2017)	1
SMURF1	4	HNRNPD	3	affinity chromatography technology	Xie Y (2013)	1
INPPL1	6	RPLP0	1	affinity chromatography technology	Brehme M (2009)	1
CYLD	2	PPM1A	1	affinity chromatography technology	Elliott PR (2016)	1
PPM1A	1	PRKAA1	2	enzymatic study	Voss M (2011)	1
EGFR	5	PRKAA1	2	affinity chromatography technology	Tong J (2014)	1
XRCC5	5	RTEL1	9	affinity chromatography technology	Hein MY (2015)	1
CYLD	2	HSPB1	2	affinity chromatography technology	Elliott PR (2016)	1
EGFR	5	GCN1	6	affinity chromatography technology	Foerster S (2013)	1
ROR2	0	PPM1B	2	two hybrid	Yao Z (2017)	1
PPM1A	1	SLC25A5	1	affinity chromatography technology	St-Denis N (2016)	1
PPM1A	1	CHEK1	2	biochemical	Wan C (2015)	1
TOR1AIP1	2	PPM1A	1	affinity chromatography technology	Hein MY (2015)	1
ARRB2	5	PPM1A	1	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
PPM1A	1	SLFN11	1	affinity chromatography technology	St-Denis N (2016)	1
SOAT1	3	PPM1B	2	affinity chromatography technology	Malty RH (2017)	1
ALK	8	PPM1A	1	two hybrid	Yao Z (2017)	1
ERBB3	3	PPM1B	2	two hybrid	Yao Z (2017)	1
AKT1	1	PAK1	2	pull down, pull down	Vadlamudi RK (2004), Joshi S (2014)	2
MAPK9	3	PPM1A	1	biochemical	Wan C (2015)	1
EGFR	5	PAK1	2	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
PPM1B	2	NAA10	9	biochemical	Wan C (2015)	1
GATD1	1	RTEL1	9	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	PPM1B	2	two hybrid	Yao Z (2017)	1
DCP1B	1	PPM1A	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
IGF1R	5	PPM1A	1	affinity chromatography technology, two hybrid	Yao Z (2017), Yao Z (2017)	2
PPM1A	1	HSD17B4	0	affinity chromatography technology	St-Denis N (2016)	1
PTK7	8	PPM1A	1	two hybrid	Yao Z (2017)	1
ERBB3	3	PPM1A	1	two hybrid	Yao Z (2017)	1
GDF3	1	PPM1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMURF1	4	PRKCA	7	enzymatic study	Andrews PS (2010)	1
HNRNPD	3	HSPB1	2	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, biochemical, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Sinsimer KS (2008), Sinsimer KS (2008), Sinsimer KS (2008), Knapinska AM (2011), Knapinska AM (2011), Knapinska AM (2011), Li ML (2013)	7
IGF1R	5	ERBB2	6	affinity chromatography technology	Riedemann J (2007)	1
ARRB1	2	AKT1	1	affinity chromatography technology	Lodeiro M (2009)	1
ARRB2	5	RPLP0	1	affinity chromatography technology	Xiao K (2007)	1
EGFR	5	PIGS	1	biochemical	Wan C (2015)	1
PPM1A	1	PPM1B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASB2	1	HNRNPD	3	affinity chromatography technology	Andresen CA (2014)	1
CHEK1	2	IGF1R	5	genetic interference	Shen JP (2017)	1
INSR	9	INPPL1	6	affinity chromatography technology, affinity chromatography technology	Vandenbroere I (2003), Onnockx S (2008)	2
SMURF1	4	XRCC5	5	affinity chromatography technology	Xie Y (2013)	1
XRCC5	5	PPM1A	1	affinity chromatography technology	Hein MY (2015)	1
PEF1	0	PPM1A	1	affinity chromatography technology	McGourty CA (2016)	1
PPM1A	1	UGGT1	6	affinity chromatography technology	St-Denis N (2016)	1
ERBB4	5	ERBB2	6	affinity chromatography technology	Huang YZ (2000)	1
PRKCA	7	EGFR	5	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Gauthier ML (2003), Gauthier ML (2003), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
PPM1A	1	FANCI	1	affinity chromatography technology	St-Denis N (2016)	1
PRKCI	1	PPM1A	1	biochemical	Wan C (2015)	1
EGFR	5	MAPK9	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
PPM1A	1	INPPL1	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXL14	2	PPM1A	1	affinity chromatography technology	Huttlin EL (2017)	1
ERBB2	6	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PPM1A	1	LETM1	6	affinity chromatography technology	St-Denis N (2016)	1
DUSP12	1	PPM1A	1	affinity chromatography technology	Li X (2016)	1
SOD1	0	PPM1A	1	affinity chromatography technology	Malty RH (2017)	1
PKN1	4	PPM1A	1	biochemical	Wan C (2015)	1
SMURF1	4	SMAD1	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, pull down, unspecified method, two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Sangadala S (2006), Komuro A (2004), Tian M (2011), Tian M (2011), Tian M (2011), Sapkota G (2007), Sapkota G (2007), Li L (2004), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011), Gao S (2009), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Colland F (2004), Cao Y (2014), Cao Y (2014), Sangadala S (2007), Gao S (2009), Wan L (2011), Wan L (2011), Zhang Y (2017), Zhang Y (2017)	28
AATK	6	PPM1B	2	two hybrid	Yao Z (2017)	1
FBXW11	2	HNRNPD	3	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014)	2
CYLD	2	SLC25A5	1	affinity chromatography technology	Elliott PR (2016)	1
ROR2	0	PPM1A	1	two hybrid	Yao Z (2017)	1
HSPB1	2	PPM1A	1	two hybrid, two hybrid	Wang J (2011), Katsogiannou M (2014)	2
PRKCI	1	PPM1B	2	biochemical	Wan C (2015)	1
DUSP22	1	PPM1A	1	affinity chromatography technology	Li X (2016)	1
ARRB2	5	PPM1B	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Xiao K (2007), Xiao K (2007), Chen TC (2014)	3
EGFR	5	HSPB1	2	affinity chromatography technology	Li J (2013)	1
CERKL	1	PPM1A	1	affinity chromatography technology	Huttlin EL (2017)	1
FGFR2	6	PPM1A	1	two hybrid	Wang J (2011)	1
INSL6	0	PPM1A	1	affinity chromatography technology	Huttlin EL (2017)	1
PPM1A	1	PAK2	0	enzymatic study	Chan PM (2008)	1
COQ2	2	SLC25A5	1	affinity chromatography technology	Malty RH (2017)	1
ERBB2	6	PPM1A	1	two hybrid	Yao Z (2017)	1
EGFR	5	NAA10	9	affinity chromatography technology	Tong J (2014)	1
ERBB3	3	SLC25A5	1	affinity chromatography technology	Li J (2013)	1
MTERF2	0	PPM1A	1	affinity chromatography technology	Huttlin EL (2017)	1
PPM1A	1	CDC42BPA	8	enzymatic study	Chan PM (2008)	1
SOAT1	3	PPM1A	1	affinity chromatography technology	Malty RH (2017)	1
LXN	0	PPM1A	1	affinity chromatography technology	Ewing RM (2007)	1
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
MAPK9	3	PKN1	4	biochemical	Havugimana PC (2012)	1
KDR	4	PPM1B	2	two hybrid	Yao Z (2017)	1