PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
USP2	0	EGFR	5	affinity chromatography technology	Kim J (2012)	1
UBE2D3	1	RNF125	0	affinity chromatography technology, two hybrid	Arimoto K (2008), Markson G (2009)	2
UBE2D1	0	CHFR	5	two hybrid, pull down, pull down, pull down	Markson G (2009), Kim JM (2010), Kang D (2002), Jung I (2012)	4
UBE2L3	1	RNF125	0	two hybrid	Markson G (2009)	1
UBE2D2	0	RNF125	0	two hybrid	Markson G (2009)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
RNF125	0	RNF125	0	enzymatic study, enzymatic study	Bijlmakers MJ (2011), Bijlmakers MJ (2016)	2
UBE2D3	1	CHFR	5	two hybrid, pull down, pull down	Markson G (2009), Chaturvedi P (2002), Liu C (2013)	3
CHFR	5	PML	7	fluorescent resonance energy transfe	Daniels MJ (2004)	1
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
UBE2K	0	RNF125	0	two hybrid	Markson G (2009)	1
PCGF1	1	RNF125	0	two hybrid	Woodsmith J (2012)	1
PCGF1	1	UBE2D3	1	pull down	Taherbhoy AM (2015)	1
UBE2E2	1	CHFR	5	two hybrid	Markson G (2009)	1
PML	7	JAK1	6	affinity chromatography technology	Alvarez E (2010)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBE2W	0	CHFR	5	two hybrid	Markson G (2009)	1
USP2	0	IL1RL2	1	enzymatic study	Saha SS (2017)	1
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
UBE2U	0	RNF125	0	two hybrid	Markson G (2009)	1
PML	7	EGFR	5	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Kuo HY (2013), Kuo HY (2013), Kuo HY (2013), Kuo HY (2013)	4
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
TRIM46	3	RNF125	0	two hybrid	Woodsmith J (2012)	1
UBE2N	1	CHFR	5	two hybrid, pull down	Markson G (2009), Liu C (2013)	2
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
UBE2D2	0	CHFR	5	two hybrid, pull down, pull down, pull down	Markson G (2009), Kang D (2002), Oh YM (2009), Chaturvedi P (2002)	4
TP53	0	PML	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014)	15
UBE2K	0	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay	Bae Y (2013), Bae Y (2013), Bae Y (2013)	3
RNF125	0	UBC	7	pull down	Giannini AL (2008)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
UBE2W	0	RNF125	0	two hybrid	Markson G (2009)	1
TP53	0	UBE2N	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Laine A (2006), Laine A (2006), Laine A (2006), Topisirovic I (2009), Topisirovic I (2009)	5
UBE2E2	1	RNF125	0	two hybrid	Markson G (2009)	1
RNF125	0	PML	7	two hybrid	Woodsmith J (2012)	1
TRIM14	1	UBE2N	1	two hybrid	Tan P (2017)	1
USP2	0	RNF125	0	two hybrid	Hayes SD (2012)	1
UBE2U	0	PCGF1	1	two hybrid	van Wijk SJ (2009)	1
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
UBE2N	1	RNF125	0	two hybrid	Markson G (2009)	1
RNF125	0	IL1RL2	1	imaging technique, affinity chromatography technology	Saha SS (2017), Saha SS (2017)	2
EGFR	5	RNF125	0	affinity chromatography technology	Yao Z (2017)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
RNF125	0	TRIM14	1	affinity chromatography technology, enzymatic study	Jia X (2017), Jia X (2017)	2
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
UBE2U	0	PML	7	two hybrid	van Wijk SJ (2009)	1
TP53	0	RNF125	0	affinity chromatography technology, affinity chromatography technology, pull down	Yang L (2015), Yang L (2015), Yang L (2015)	3
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
UBE2D4	0	CHFR	5	two hybrid	Markson G (2009)	1
RNF125	0	CHFR	5	two hybrid	Woodsmith J (2012)	1
UBE2L6	0	RNF125	0	two hybrid	Markson G (2009)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
USP2	0	TRIM46	3	two hybrid	Hayes SD (2012)	1
UBE2U	0	TRIM46	3	two hybrid	Markson G (2009)	1
UBE2D1	0	RNF125	0	two hybrid, pull down, pull down	Markson G (2009), Bijlmakers MJ (2011), Bijlmakers MJ (2016)	3
RNF125	0	JAK1	6	affinity chromatography technology, affinity chromatography technology	Kim H (2015), Kim H (2015)	2
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
UBE2D4	0	RNF125	0	two hybrid	Markson G (2009)	1
EGFR	5	JAK1	6	affinity chromatography technology	Tong J (2008)	1