PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PPP1R8	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
RTCB	1	PPP1R8	0	biochemical	Wan C (2015)	1
SF3B1	12	PPP1R8	0	two hybrid, pull down, affinity chromatography technology	Boudrez A (2002), Boudrez A (2002), Boudrez A (2002)	3
NF2	1	RBBP4	3	affinity chromatography technology	Zhou L (2015)	1
DDX1	6	FAM98B	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
APP	1	HSPA8	4	affinity chromatography technology	Yamamoto YH (2010)	1
PPP1R8	0	WDR77	2	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
GTF2E2	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PPP1R8	0	SNUPN	2	biochemical	Wan C (2015)	1
PPP1CC	2	APP	1	pull down	Olah J (2011)	1
RBBP4	3	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Y (2003), Hakimi MA (2003), Zhang Y (2002), Tong JK (1998), Sun JM (2007), Sun JM (2007), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Wan C (2015), Hauri S (2016)	14
EZH2	4	SF3B1	12	affinity chromatography technology	Cao Q (2014)	1
PPP1CA	3	PPP1CB	9	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
CYP1A1	1	PPP1R8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC2	1	SETDB1	3	affinity chromatography technology	Yang L (2003)	1
PPP1R8	0	ERG28	0	two hybrid	Stelzl U (2005)	1
PPP1R8	0	RBM48	1	two hybrid	Stelzl U (2005)	1
FBXO25	1	HSPA8	4	affinity chromatography technology	Teixeira FR (2010)	1
APP	1	NME2	0	affinity chromatography technology	Huttlin EL (2017)	1
HSPA8	4	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Polanowska-Grabowska R (1997), Cid C (2007)	2
FBXO25	1	PPP1R8	0	enzymatic study	Teixeira FR (2013)	1
PPP1R8	0	EZH2	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Roy N (2007), Roy N (2007), Roy N (2007), Roy N (2007), Van Dessel N (2010)	5
SHC1	0	APP	1	pull down, affinity chromatography technology	Tarr PE (2002), Tarr PE (2002)	2
LYN	2	PPP1R8	0	enzymatic study	Beullens M (2000)	1
SF3A2	1	CTNNBL1	1	affinity chromatography technology	Behzadnia N (2007)	1
PPP1CB	9	PPP1R8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Ewing RM (2007), Lee JH (2010), Hein MY (2015), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	6
KRAS	1	SHC1	0	genetic interference	Hart T (2015)	1
PPP1R8	0	HMGA1	0	far western blotting	Sgarra R (2008)	1
EZH2	4	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	van der Vlag J (1999), van der Vlag J (1999), Tong ZT (2012), Tong ZT (2012), Wan C (2015)	5
DDX1	6	APP	1	pull down	Olah J (2011)	1
PPP1R8	0	FAM98B	2	biochemical	Wan C (2015)	1
PPP1R8	0	VPS4B	3	biochemical	Wan C (2015)	1
NF2	1	PPP1R8	0	biochemical	Havugimana PC (2012)	1
SF3A2	1	SF3B1	12	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Will CL (2002), Behzadnia N (2007), Havugimana PC (2012), Wan C (2015)	4
EED	1	SF3B1	12	affinity chromatography technology	Cao Q (2014)	1
APP	1	HMGA1	0	pull down	Virok DP (2011)	1
PPP1R8	0	DDX1	6	biochemical	Wan C (2015)	1
SHMT2	3	APP	1	pull down	Olah J (2011)	1
USP47	4	CTNNBL1	1	affinity chromatography technology	Huttlin EL (2017)	1
SUZ12	0	SF3B1	12	affinity chromatography technology	Cao Q (2014)	1
CTNNBL1	1	PPP1R8	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
GTF2E2	2	PPP1R8	0	affinity chromatography technology	Huttlin EL (2017)	1
CYP1A1	1	CTNNBL1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SF3A2	1	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Behzadnia N (2007), Huttlin EL (2017)	2
PPP1R8	0	APPBP2	3	two hybrid	Rolland T (2014)	1
EED	1	RBBP4	3	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Hein MY (2015), Hauri S (2016), Hauri S (2016)	5
SF3A2	1	PPP1R8	0	affinity chromatography technology	Behzadnia N (2007)	1
PPP1CA	3	PPP1R8	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Jin Q (2003), Ajuh PM (2000), Van Dessel N (2010), Lee JH (2010), Havugimana PC (2012), Hegele A (2012), Hegele A (2012), Colland F (2004), Huttlin EL (2015), Wan C (2015), St-Denis N (2016), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017)	15
SHMT2	3	DDX1	6	biochemical	Wan C (2015)	1
PRKACA	2	PPP1R8	0	enzymatic study	Vulsteke V (1997)	1
PPP1R8	0	SUZ12	0	affinity chromatography technology	Van Dessel N (2010)	1
USP47	4	PPP1R8	0	affinity chromatography technology	Huttlin EL (2017)	1
PPP1R8	0	PPP1CC	2	pull down, affinity chromatography technology, biochemical, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Beullens M (2000), Lee JH (2010), Havugimana PC (2012), Esteves SL (2012), Fardilha M (2011), Huttlin EL (2015), Wan C (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	12
KRAS	1	APP	1	pull down	Olah J (2011)	1
PPP1R8	0	SHC1	0	biochemical	Wan C (2015)	1
HDAC2	1	SUZ12	0	biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Pasini D (2010), Wan C (2015)	3
PPP1R8	0	STC2	0	two hybrid	Stelzl U (2005)	1
PPP1R8	0	HDAC2	1	pull down, affinity chromatography technology	Jin Q (2003), Jin Q (2003)	2
PPIL1	1	PPP1R8	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
SNRNP27	0	CTNNBL1	1	affinity chromatography technology	Huttlin EL (2017)	1
PPP1R3A	2	PPP1CB	9	affinity chromatography technology	Hauri S (2013)	1
NME2	0	PPP1R8	0	affinity chromatography technology	Ewing RM (2007)	1
APP	1	APPBP2	3	two hybrid, pull down, affinity chromatography technology	Zheng P (1998), Zheng P (1998), Briand S (2011)	3
SF3A2	1	PPP1CA	3	affinity chromatography technology	Behzadnia N (2007)	1
PPP1R8	0	APP	1	pull down	Olah J (2011)	1
PPP1R3A	2	PPP1R8	0	affinity chromatography technology	Hauri S (2013)	1
PPP1R3A	2	PPP1CA	3	affinity chromatography technology	Hauri S (2013)	1
EED	1	SUZ12	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Sarma K (2008), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Chan YS (2013), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	22
PPP1R8	0	SHMT2	3	biochemical	Wan C (2015)	1
EED	1	HDAC2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Cao Q (2014)	6
EED	1	HSPA8	4	affinity chromatography technology	Cao Q (2014)	1
EZH2	4	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su IH (2005), Aoto T (2008), Hansen KH (2008), Li G (2010), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Pasini D (2008), Sarma K (2008), Xu B (2011), Xu B (2011), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Lee ST (2011), Havugimana PC (2012), Sahasrabuddhe AA (2014), Wang L (2013), Wu L (2013), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Bhatnagar S (2014), Bhatnagar S (2014), Zhao R (2015), Wienken M (2016), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Mahara S (2016), Hauri S (2016), Hauri S (2016)	40
SETDB1	3	SUZ12	0	biochemical	Wang H (2003)	1
HMGA1	0	HDAC2	1	imaging technique	Forzati F (2012)	1
SUZ12	0	WDR77	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Furuno K (2006), Furuno K (2006), Furuno K (2006), Patel SR (2012)	4
STXBP1	38	APP	1	pull down	Olah J (2011)	1
STXBP1	38	SHC1	0	biochemical	Wan C (2015)	1
EZH2	4	RBBP4	3	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Kaneko S (2010), Kaneko S (2010), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	7
PPIL1	1	WDR77	2	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
PPP1CC	2	HSPA8	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cid C (2007), Cid C (2007), Fardilha M (2011)	3
PPP1R8	0	RBBP4	3	affinity chromatography technology	Van Dessel N (2010)	1
PPP1CC	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017)	8
EZH2	4	EED	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Lohuizen M (1998), van Lohuizen M (1998), van Lohuizen M (1998), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Pasini D (2004), Cao R (2004), Su IH (2005), Hansen KH (2008), Margueron R (2008), Margueron R (2008), Shen X (2008), Shen X (2008), Hernandez-Munoz I (2005), Sarma K (2008), Sarma K (2008), Han Z (2007), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Satijn DP (2001), Satijn DP (2001), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Wang L (2013), Wu L (2013), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Chan YS (2013), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	49
SHMT2	3	GTF2E2	2	affinity chromatography technology	Castello A (2012)	1
PPP1R8	0	GBP2	0	two hybrid	Stelzl U (2005)	1
DDX1	6	PPP1CA	3	biochemical	Havugimana PC (2012)	1
RTCB	1	DDX1	6	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	4
SUZ12	0	RBBP4	3	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Cao R (2004), Havugimana PC (2012), Pasini D (2010), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
SNRNP27	0	PPP1R8	0	affinity chromatography technology	Huttlin EL (2017)	1
KRAS	1	PPP1R8	0	genetic interference	Luo J (2009)	1
HSPA8	4	PPP1R8	0	affinity chromatography technology	Huttlin EL (2017)	1
PPP1R8	0	CRMP1	0	two hybrid	Stelzl U (2005)	1
PPP1CA	3	EED	1	pull down	Jin Q (2003)	1
RTCB	1	FAM98B	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CTNNBL1	1	WDR77	2	affinity chromatography technology	Ganesh K (2011)	1
PPP1R8	0	EED	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Jin Q (2003), Jin Q (2003), Jin Q (2003), Jin Q (2003), Roy N (2007)	5
SHC1	0	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
PPP1CB	9	PPP1CC	2	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
LYN	2	SHC1	0	affinity chromatography technology	Ptasznik A (1995)	1
STXBP1	38	PPP1R8	0	biochemical	Wan C (2015)	1
EED	1	PPP1CB	9	affinity chromatography technology	Cao Q (2014)	1