PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KAT8	2	PAF1	6	pull down	Wu L (2014)	1
KAT8	2	MSL3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Smith ER (2005), Smith ER (2005), Sharma GG (2010), Kadlec J (2011)	4
HIST2H2AC	1	HIST2H2BE	1	pull down	Long L (2014)	1
YWHAZ	1	KAT8	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Zippo A (2009), Zippo A (2009), Zippo A (2009)	3
KAT8	2	MSL1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Smith ER (2005), Smith ER (2005), Sharma GG (2010), Sharma GG (2010), Kadlec J (2011), Kadlec J (2011), Huttlin EL (2015), Huttlin EL (2017)	8
KAT8	2	MSL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Smith ER (2005), Smith ER (2005), Sharma GG (2010), Huttlin EL (2017)	4
MSL1	0	CDK9	3	biochemical	Wu L (2014)	1
FAM96B	0	MMS19	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Stehling O (2012), Stehling O (2012), Lev I (2013), Stehling O (2013), Stehling O (2013), Gari K (2012), Gari K (2012), Huttlin EL (2015), Huttlin EL (2017)	10
TP53	0	RNF20	9	pull down, affinity chromatography technology	Kim J (2005), Kim J (2005)	2
RNF40	11	MSL2	3	biochemical, biochemical	Wu L (2014), Wu L (2014)	2
MSL1	0	HIST2H2BE	1	enzymatic study	Wu L (2014)	1
YWHAE	0	HIST1H4A	0	affinity chromatography technology	Zippo A (2009)	1
MSL1	0	MSL2	3	affinity chromatography technology, x-ray crystallography, affinity chromatography technology	Smith ER (2005), Hallacli E (2012), Huttlin EL (2017)	3
MSL2	3	UBE2D3	1	pull down, pull down	Wu L (2011), Wu L (2014)	2
MSL2	3	HIST2H2AC	1	enzymatic study	Wu L (2011)	1
TP53	0	TRIM8	6	affinity chromatography technology	Caratozzolo MF (2012)	1
MSL3	4	HIST1H4A	0	enzymatic study	Smith ER (2005)	1
MMS19	5	MSL1	0	affinity chromatography technology	Stehling O (2012)	1
MSL1	0	PAF1	6	biochemical, biochemical, pull down, pull down	Wu L (2014), Wu L (2014), Wu L (2014), Wu L (2014)	4
RNF20	9	HIST2H3C	0	enzymatic study	Kim J (2011)	1
MSL3	4	MSL2	3	affinity chromatography technology, affinity chromatography technology	Smith ER (2005), Huttlin EL (2017)	2
MSL2	3	TRIM8	6	two hybrid	Woodsmith J (2012)	1
RNF40	11	MSL1	0	biochemical, biochemical, pull down	Wu L (2014), Wu L (2014), Wu L (2014)	3
MSL2	3	PAF1	6	biochemical, biochemical, pull down, pull down	Wu L (2014), Wu L (2014), Wu L (2014), Wu L (2014)	4
YWHAZ	1	MSL2	3	two hybrid	Bandyopadhyay S (2010)	1
RNF20	9	MSL1	0	biochemical, biochemical, pull down, pull down	Wu L (2014), Wu L (2014), Wu L (2014), Wu L (2014)	4
MSL3	4	PAF1	6	pull down	Wu L (2014)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
MSL2	3	HIST1H4A	0	enzymatic study	Wu L (2011)	1
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
HIST2H2BE	1	CDK9	3	biochemical, pull down	Wu L (2014), Wu L (2014)	2
TP53	0	CDK9	3	genetic interference, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	De Falco G (2000), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006)	6
MSL2	3	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology	Kruse JP (2009), Kruse JP (2009), Kruse JP (2009)	3
PAF1	6	RNF20	9	affinity chromatography technology, biochemical, biochemical, pull down	Zhu B (2005), Wu L (2014), Wu L (2014), Wu L (2014)	4
KAT8	2	HIST1H4A	0	enzymatic study, affinity chromatography technology, imaging technique, enzymatic study	Smith ER (2005), Zippo A (2009), Zippo A (2009), Tropberger P (2013)	4
TP53	0	HBB	0	affinity chromatography technology	Kikuchi J (2003)	1
RNF20	9	RNF40	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Zhang F (2011), Jaeaeskelaeinen T (2011), Jaeaeskelaeinen T (2011), Moyal L (2011), Moyal L (2011), Zhu B (2005), Kim J (2009), Bedi U (2015), Klement K (2014), Duan Y (2016), Duan Y (2016), Foglizzo M (2016)	12
MSL1	0	UBE2D3	1	pull down	Wu L (2014)	1
TRIM25	5	YWHAZ	1	affinity chromatography technology	Choudhury NR (2017)	1
MSL2	3	HIST2H2BE	1	enzymatic study, enzymatic study	Wu L (2011), Wu L (2014)	2
MSL2	3	3501	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	MSL2	3	affinity chromatography technology	Choudhury NR (2017)	1
HIST1H4A	0	HIST2H2AC	1	pull down, pull down	Shiio Y (2003), Boenisch C (2012)	2
TRIM25	5	YWHAE	0	affinity chromatography technology	Choudhury NR (2017)	1
CDK9	3	PAF1	6	affinity chromatography technology, biochemical, biochemical	He N (2011), Wu L (2014), Wu L (2014)	3
YWHAZ	1	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology	Waterman MJ (1998), Waterman MJ (1998), Gu YM (2006)	3
MSL2	3	HIST2H3C	0	enzymatic study	Wu L (2011)	1
YWHAE	0	MSL2	3	two hybrid	Bandyopadhyay S (2010)	1
RNF40	11	CDK9	3	biochemical	Wu L (2014)	1
KAT8	2	TP53	0	enzymatic study, enzymatic study, pull down	Sykes SM (2006), Li X (2009), Dou Y (2005)	3
MSL3	4	MSL1	0	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Smith ER (2005), Sharma GG (2010), Kadlec J (2011), Huttlin EL (2015), Huttlin EL (2017)	5
FAM96B	0	MSL1	0	affinity chromatography technology	Stehling O (2013)	1
RNF20	9	HIST2H2AC	1	enzymatic study	Kim J (2011)	1
MSL2	3	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
YWHAG	5	MSL2	3	two hybrid	Bandyopadhyay S (2010)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
RNF40	11	PAF1	6	biochemical, biochemical	Wu L (2014), Wu L (2014)	2
MMS19	5	MSL2	3	affinity chromatography technology	Stehling O (2012)	1
UBE2D3	1	TRIM8	6	two hybrid	Markson G (2009)	1
RNF20	9	CDK9	3	biochemical, biochemical	Wu L (2014), Wu L (2014)	2
TRIM25	5	TRIM8	6	two hybrid	Woodsmith J (2012)	1
MSL2	3	HIST2H2AA3	0	enzymatic study	Wu L (2011)	1
RNF20	9	MSL2	3	biochemical, biochemical	Wu L (2014), Wu L (2014)	2
YWHAE	0	KAT8	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Zippo A (2009), Zippo A (2009), Zippo A (2009)	3
MSL2	3	HBA2	0	affinity chromatography technology	Huttlin EL (2017)	1
MSL2	3	CDK9	3	biochemical, biochemical	Wu L (2014), Wu L (2014)	2
RNF20	9	HIST2H2BE	1	enzymatic study, enzymatic study, enzymatic study	Kim J (2011), Zhu B (2005), Wu L (2014)	3
RNF20	9	HIST2H2AA3	0	enzymatic study	Kim J (2011)	1
TP53	0	YWHAE	0	affinity chromatography technology	Fogeron ML (2013)	1
HIST1H4A	0	HIST2H2BE	1	pull down	Shiio Y (2003)	1
YWHAZ	1	HIST1H4A	0	affinity chromatography technology	Zippo A (2009)	1
FAM96B	0	MSL2	3	affinity chromatography technology	Stehling O (2013)	1
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
RNF40	11	HIST2H2BE	1	enzymatic study, enzymatic study	Zhu B (2005), Wu L (2014)	2