PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	CIRBP	1	affinity chromatography technology	Abdelmohsen K (2009)	1
HMGA2	1	SMAD9	0	affinity chromatography technology	Monzen K (2008)	1
ELAVL1	0	BMI1	0	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Cao Q (2014)	2
MALT1	1	SUV39H1	0	two hybrid	Weimann M (2013)	1
ID2	0	PRMT6	2	two hybrid	Weimann M (2013)	1
HESX1	0	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
MRPL38	2	PRMT6	2	two hybrid, affinity chromatography technology	Weimann M (2013), Huttlin EL (2017)	2
GSTCD	1	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
HNRNPH2	2	PRMT6	2	two hybrid	Weimann M (2013)	1
PRMT6	2	HIST2H3C	0	enzymatic study, enzymatic study	Hyllus D (2007), Cloutier P (2013)	2
TSC1	4	NEFL	1	two hybrid, affinity chromatography technology	Haddad LA (2002), Haddad LA (2002)	2
KIF9	2	SSX2IP	0	two hybrid	Rolland T (2014)	1
MALT1	1	PRMT6	2	two hybrid	Weimann M (2013)	1
FAM19A3	0	PRMT6	2	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	PRMT6	2	affinity chromatography technology	Abdelmohsen K (2009)	1
GRHL3	3	PRMT5	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
SUV39H1	0	PRMT6	2	two hybrid	Weimann M (2013)	1
HOXA1	4	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
UBR7	0	PRMT6	2	biochemical	Kristensen AR (2012)	1
PRMT6	2	HIST2H3A	0	enzymatic study	Iberg AN (2008)	1
PRMT6	2	TFCP2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST2H2AA3	0	BMI1	0	affinity chromatography technology, enzymatic study	Richly H (2010), Bentley ML (2011)	2
AKT3	3	PRMT6	2	affinity chromatography technology	Huttlin EL (2017)	1
LYPD4	1	SEC23IP	3	affinity chromatography technology	Huttlin EL (2017)	1
GTPBP2	1	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
BMI1	0	FBL	1	affinity chromatography technology	Cao Q (2014)	1
PYGO1	0	PRMT6	2	two hybrid	Weimann M (2013)	1
DDX23	3	PRMT6	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OAS1	3	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
FOXC1	0	TFCP2	1	affinity chromatography technology	Li X (2015)	1
ELAVL1	0	SPIN1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MTF2	4	PRMT6	2	two hybrid	Weimann M (2013)	1
PRMT6	2	TP73	2	affinity chromatography technology	Huttlin EL (2015)	1
NR1D2	1	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
FOXA1	2	UBP1	2	affinity chromatography technology	Li X (2015)	1
LOXL4	1	SUV39H1	0	two hybrid	Weimann M (2013)	1
ELAVL1	0	SPSB1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
PSMD11	0	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
ELAVL1	0	MED28	2	affinity chromatography technology	Abdelmohsen K (2009)	1
AP1G2	4	PRMT6	2	two hybrid	Weimann M (2013)	1
SSX2IP	0	PRMT6	2	two hybrid	Weimann M (2013)	1
CDCA4	1	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
ASB3	0	PRMT6	2	two hybrid	Weimann M (2013)	1
SERGEF	0	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
MNDA	0	PRMT6	2	two hybrid	Weimann M (2013)	1
LENG8	2	PRMT6	2	two hybrid	Weimann M (2013)	1
TP73	2	DDX23	3	affinity chromatography technology	Lunardi A (2010)	1
SSX2IP	0	DNAJA3	2	affinity chromatography technology	Gupta GD (2015)	1
PRMT6	2	SMG7	3	affinity chromatography technology	Huttlin EL (2015)	1
ID2	0	PRMT5	3	affinity chromatography technology	Lee SB (2016)	1
SPIN1	1	PRMT6	2	two hybrid	Weimann M (2013)	1
ILF2	3	PRMT6	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WDFY3	17	SUV39H1	0	two hybrid	Weimann M (2013)	1
DXO	4	PRMT6	2	two hybrid	Weimann M (2013)	1
SOST	2	PRMT6	2	affinity chromatography technology	Huttlin EL (2017)	1
STARD10	1	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
SRGAP3	8	PRMT6	2	two hybrid	Weimann M (2013)	1
FOSL2	2	PRMT6	2	affinity chromatography technology	Huttlin EL (2015)	1
LDHAL6B	0	SUV39H1	0	two hybrid	Weimann M (2013)	1
KIAA0408	0	PRMT6	2	two hybrid	Weimann M (2013)	1
LEF1	3	PRMT6	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAM19A3	0	TFCP2	1	affinity chromatography technology	Huttlin EL (2017)	1
C8orf74	0	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
HOXC4	1	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
KLHL20	2	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
PRMT6	2	FOXC1	0	affinity chromatography technology	Huttlin EL (2015)	1
HIST2H3A	0	SPIN1	1	affinity chromatography technology, affinity chromatography technology	Kleiner RE (2018), Kleiner RE (2018)	2
CIRBP	1	PRMT6	2	affinity chromatography technology	Huttlin EL (2017)	1
LOXL4	1	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
FKBP7	2	PRMT6	2	two hybrid	Weimann M (2013)	1
DCAF16	0	PRMT6	2	two hybrid	Weimann M (2013)	1
WDFY3	17	PRMT6	2	two hybrid	Weimann M (2013)	1
THEMIS	2	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
ID2	0	SUV39H1	0	two hybrid	Weimann M (2013)	1
SMAD9	0	DNAJA3	2	two hybrid	Colland F (2004)	1
LDHAL6B	0	PRMT6	2	two hybrid	Weimann M (2013)	1
PRMT6	2	UBP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FOXA1	2	PRMT6	2	affinity chromatography technology	Jozwik KM (2016)	1
TFCP2	1	UBP1	2	two hybrid, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2017)	2
BCAT1	6	PRMT6	2	two hybrid	Weimann M (2013)	1
FOXC1	0	UBP1	2	affinity chromatography technology	Li X (2015)	1
NOSTRIN	0	PRMT6	2	two hybrid	Weimann M (2013)	1
TEX35	0	SUV39H1	0	two hybrid	Weimann M (2013)	1
TSC1	4	PRMT6	2	two hybrid	Weimann M (2013)	1
DNALI1	0	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
TCF7L2	12	LEF1	3	affinity chromatography technology	Jia Y (2014)	1
GBE1	0	PRMT6	2	two hybrid	Weimann M (2013)	1
OPA3	1	SUV39H1	0	two hybrid	Weimann M (2013)	1
ENAH	0	RAC1	7	fluorescent resonance energy transfe, pull down	Higashi M (2009), Higashi M (2009)	2
H3F3C	0	PRMT6	2	two hybrid	Weimann M (2013)	1
FOXA1	2	FIP1L1	2	affinity chromatography technology	Jozwik KM (2016)	1
PRMT6	2	KIRREL1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	UBP1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
PRMT6	2	HIST2H2BE	1	enzymatic study	Cloutier P (2013)	1
ELAVL1	0	SSX2IP	0	affinity chromatography technology	Abdelmohsen K (2009)	1
LDHAL6B	0	PRMT5	3	two hybrid	Weimann M (2013)	1
GTPBP2	1	PRMT5	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
ZNF436	3	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
FOXA1	2	CIRBP	1	affinity chromatography technology	Jozwik KM (2016)	1
ELAVL1	0	CDCA4	1	affinity chromatography technology	Abdelmohsen K (2009)	1
HOXA1	4	PRMT6	2	two hybrid	Weimann M (2013)	1
ELAVL1	0	ENAH	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BMI1	0	ILF2	3	affinity chromatography technology	Cao Q (2014)	1
PRMT6	2	SEC23IP	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BMI1	0	LENG8	2	affinity chromatography technology	Cao Q (2014)	1
RASSF2	2	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
PRMT6	2	HIST4H4	1	enzymatic study	Hyllus D (2007)	1
TDO2	0	PRMT6	2	two hybrid	Weimann M (2013)	1
KIF9	2	PRMT6	2	affinity chromatography technology, two hybrid, two hybrid	Weimann M (2013), Weimann M (2013), Rolland T (2014)	3
NEFL	1	PRMT6	2	two hybrid	Weimann M (2013)	1
ZSCAN9	0	SUV39H1	0	two hybrid	Weimann M (2013)	1
LENG8	2	SUV39H1	0	two hybrid	Weimann M (2013)	1
FYCO1	6	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
SMARCD1	5	PRMT6	2	two hybrid	Weimann M (2013)	1
GRHL3	3	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
HOXC4	1	PRMT5	3	two hybrid	Weimann M (2013)	1
PRMT6	2	ATP1A3	15	affinity chromatography technology	Huttlin EL (2015)	1
ELAVL1	0	MTF2	4	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	PABPC1	5	affinity chromatography technology	Abdelmohsen K (2009)	1
ZNF436	3	PRMT5	3	two hybrid	Weimann M (2013)	1
SSX2IP	0	SMG7	3	bioid	Gupta GD (2015)	1
AK8	1	PRMT6	2	two hybrid	Weimann M (2013)	1
ILF2	3	MRPL38	2	biochemical	Havugimana PC (2012)	1
FOSL2	2	DNAJA3	2	two hybrid	Rolland T (2014)	1
BMI1	0	PRMT6	2	genetic interference	Wong AS (2016)	1
SPSB1	3	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
BMI1	0	HIST4H4	1	affinity chromatography technology	Cao Q (2014)	1
RAD17	2	PRMT6	2	two hybrid	Weimann M (2013)	1
PRMT6	2	MADD	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRMT6	2	PPP1R1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRGAP3	8	SUV39H1	0	two hybrid	Weimann M (2013)	1
METTL27	0	PRMT6	2	two hybrid	Weimann M (2013)	1
TCF7L2	12	PRMT6	2	affinity chromatography technology	Huttlin EL (2017)	1
MTF2	4	SUV39H1	0	two hybrid	Weimann M (2013)	1
ZNF436	3	PRMT6	2	two hybrid	Weimann M (2013)	1
ELAVL1	0	FOXA1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HOXC4	1	PRMT6	2	two hybrid	Weimann M (2013)	1
MED28	2	FYN	1	affinity chromatography technology	Lu M (2006)	1
ELAVL1	0	SMG7	3	affinity chromatography technology	Abdelmohsen K (2009)	1
PRMT6	2	N4BP2L2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIB2	2	PRMT6	2	two hybrid	Weimann M (2013)	1
ELAVL1	0	ASB3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD9	0	ZNF557	3	two hybrid	Colland F (2004)	1
PRMT6	2	HIST2H2AA3	0	enzymatic study	Cloutier P (2013)	1
PELO	1	PRMT6	2	two hybrid	Weimann M (2013)	1
SLU7	2	PRMT6	2	two hybrid	Weimann M (2013)	1
HIST2H3A	0	UBR7	0	affinity chromatography technology, affinity chromatography technology, unspecified method	Kleiner RE (2018), Kleiner RE (2018), Kleiner RE (2018)	3
388407	0	PRMT6	2	two hybrid	Weimann M (2013)	1
PCGF5	1	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
ELAVL1	0	AUNIP	3	affinity chromatography technology	Abdelmohsen K (2009)	1
SPSB1	3	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
ZSCAN9	0	PRMT6	2	two hybrid	Weimann M (2013)	1
CIRBP	1	PRMT5	3	affinity chromatography technology	Huttlin EL (2017)	1
PRMT6	2	GPS2	0	enzymatic study	Huang J (2015)	1
CIRBP	1	HNRNPH2	2	biochemical	Havugimana PC (2012)	1
LENG8	2	PRMT5	3	two hybrid	Weimann M (2013)	1
PRMT6	2	FBL	1	enzymatic study	Miranda TB (2005)	1
SPATA22	1	PRMT6	2	two hybrid	Weimann M (2013)	1
TP73	2	SPSB1	3	affinity chromatography technology	Lunardi A (2010)	1
OPA3	1	PRMT6	2	two hybrid	Weimann M (2013)	1
BMI1	0	CIRBP	1	affinity chromatography technology	Cao Q (2014)	1
PRMT6	2	PABPC1	5	enzymatic study	Sgarra R (2006)	1
RAC1	7	PRMT6	2	two hybrid	Weimann M (2013)	1
ID2	0	KLHL20	2	affinity chromatography technology	Huttlin EL (2017)	1
FOXA1	2	HMGA1	0	affinity chromatography technology	Li X (2015)	1
SUV39H1	0	HIST2H3A	0	enzymatic study	Gyory I (2004)	1
LYPD4	1	N4BP2L2	3	affinity chromatography technology	Huttlin EL (2017)	1
SLU7	2	PRMT5	3	two hybrid	Weimann M (2013)	1
SMAD9	0	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
BMP3	2	PRMT6	2	two hybrid	Weimann M (2013)	1
PYCR3	0	PRMT6	2	two hybrid	Weimann M (2013)	1
H3F3C	0	PRMT5	3	two hybrid	Weimann M (2013)	1
ELAVL1	0	TCF7L2	12	affinity chromatography technology	Abdelmohsen K (2009)	1
SNF8	2	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
CETN2	0	PRMT6	2	two hybrid	Wang J (2011)	1
FYN	1	SUV39H1	0	two hybrid	Weimann M (2013)	1
UBXN10	2	PRMT6	2	two hybrid	Weimann M (2013)	1
LYPD4	1	PRMT6	2	affinity chromatography technology	Huttlin EL (2017)	1
PRMT5	3	HIST4H4	1	enzymatic study, unspecified method, enzymatic study	Lacroix M (2008), Burgos ES (2015), Burgos ES (2015)	3
RASSF2	2	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
MLC1	0	PRMT6	2	two hybrid	Weimann M (2013)	1
ELAVL1	0	HOXA5	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BCAT1	6	SNF8	2	biochemical	Kristensen AR (2012)	1
ZFC3H1	6	LENG8	2	affinity chromatography technology	Hein MY (2015)	1
FYN	1	PRMT6	2	two hybrid	Weimann M (2013)	1
PRMT6	2	PRMT5	3	genetic interference	Wong AS (2016)	1
CDCA4	1	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
MED28	2	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
PRMT6	2	DNAJC12	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HOXA1	4	N4BP2L2	3	two hybrid	Rolland T (2014)	1
PRMT6	2	8361	0	enzymatic study	Cloutier P (2013)	1
PRMT6	2	HMGA2	1	enzymatic study, far western blotting	Sgarra R (2006), Sgarra R (2006)	2
H3F3C	0	SUV39H1	0	two hybrid	Weimann M (2013)	1
ELAVL1	0	GBE1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
HOXA5	0	PRMT6	2	two hybrid	Weimann M (2013)	1
FAM19A3	0	UBP1	2	affinity chromatography technology	Huttlin EL (2017)	1
BLZF1	0	PRMT6	2	two hybrid	Weimann M (2013)	1
ZFC3H1	6	PRMT6	2	affinity chromatography technology	Huttlin EL (2017)	1
ZNF557	3	SUV39H1	0	two hybrid	Weimann M (2013)	1
KLHL20	2	SUV39H1	0	two hybrid	Weimann M (2013)	1
PRMT6	2	DYNC2LI1	0	affinity chromatography technology	Huttlin EL (2015)	1
388407	0	SUV39H1	0	two hybrid	Weimann M (2013)	1
FOXA1	2	HNRNPH2	2	affinity chromatography technology	Jozwik KM (2016)	1
DNAJA3	2	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
GTPBP2	1	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
TEX35	0	PRMT6	2	two hybrid	Weimann M (2013)	1
FIP1L1	2	PRMT6	2	two hybrid	Weimann M (2013)	1
FBL	1	PRMT5	3	affinity chromatography technology, affinity chromatography technology	Yanagida M (2004), Huttlin EL (2017)	2
ZNF557	3	PRMT6	2	two hybrid	Weimann M (2013)	1
PRMT6	2	HMGA1	0	enzymatic study, far western blotting, affinity chromatography technology, enzymatic study	Sgarra R (2006), Sgarra R (2006), Sgarra R (2006), Miranda TB (2005)	4
TMED5	0	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
PRMT6	2	ENAH	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
C8orf74	0	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
AUNIP	3	PRMT6	2	two hybrid	Weimann M (2013)	1
PEX7	1	PRMT6	2	two hybrid	Weimann M (2013)	1
ELAVL1	0	FOXC1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PYGO1	0	LENG8	2	two hybrid	Bandyopadhyay S (2010)	1
PRMT6	2	UBR4	15	affinity chromatography technology	Huttlin EL (2015)	1
HOXA1	4	BLZF1	0	two hybrid	Rolland T (2014)	1