PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BTRC	1	RASSF1	3	two hybrid, affinity chromatography technology, bioid, affinity chromatography technology	Vinayagam A (2011), Zhou X (2012), Coyaud E (2015), Huttlin EL (2017)	4
DCTN1	6	ANXA1	1	bioid	Gupta GD (2015)	1
MAP1S	3	MAP1B	5	affinity chromatography technology	Hauri S (2013)	1
RASSF5	2	STK3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Wang J (2011), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	7
FBXW11	2	MAP1S	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015), Low TY (2014)	3
FKBP3	0	MAP1S	3	biochemical	Kristensen AR (2012)	1
BTRC	1	MAP1S	3	bioid, affinity chromatography technology	Coyaud E (2015), Huttlin EL (2017)	2
BTRC	1	RASSF3	2	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Loveless TB (2015), Loveless TB (2015), Coyaud E (2015), Huttlin EL (2017)	4
STK4	1	RASSF3	2	bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	4
NTRK1	1	MAP1S	3	affinity chromatography technology	Emdal KB (2015)	1
HDAC4	10	MAP1S	3	two hybrid	Wang AH (2005)	1
NTRK1	1	SRPK2	1	affinity chromatography technology	Emdal KB (2015)	1
FBXW11	2	STK3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Kim TY (2014), Coyaud E (2015)	3
NTRK1	1	FKBP3	0	affinity chromatography technology	Emdal KB (2015)	1
FAS	2	MAP1S	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	SYNCRIP	6	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	ANXA2	0	affinity chromatography technology	Emdal KB (2015)	1
CNPY2	2	MAP1S	3	biochemical	Wan C (2015)	1
MAP1S	3	GSN	3	affinity chromatography technology	Hauri S (2013)	1
RASSF5	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Schmidt ML (2014), Schmidt ML (2014), Rolland T (2014)	3
SRPK2	1	PPM1G	1	biochemical	Wan C (2015)	1
FBXW11	2	MAP1B	5	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014)	2
PIN1	0	MAP1S	3	pull down	Ingham RJ (2005)	1
TRAPPC1	0	MAP1S	3	affinity chromatography technology	Huttlin EL (2017)	1
FBXW11	2	RASSF3	2	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Loveless TB (2015)	2
RASSF1	3	MAP1B	5	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dallol A (2004), Dallol A (2004), Huttlin EL (2015), Hauri S (2013), Huttlin EL (2017)	5
MAP1LC3A	0	MAP1S	3	affinity chromatography technology, affinity chromatography technology, pull down	Xie R (2011), Xie R (2011), Xie R (2011)	3
BTRC	1	PPM1G	1	bioid	Coyaud E (2015)	1
STK4	1	ANXA1	1	affinity chromatography technology	Hauri S (2013)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
FKBP3	0	SYNCRIP	6	biochemical	Kristensen AR (2012)	1
MAP1S	3	ANXA1	1	affinity chromatography technology	Hauri S (2013)	1
SPICE1	2	MAP1S	3	bioid	Gupta GD (2015)	1
MAP1LC3A	0	ATG3	4	affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Behrends C (2010), Gao Z (2010), Lee JS (2009), Sou YS (2006), Sou YS (2006), Zhang F (2014)	6
BTRC	1	STK3	1	affinity chromatography technology, bioid, affinity chromatography technology	Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	3
SOCS3	0	PIN1	0	two hybrid	Stelzl U (2005)	1
RASSF5	2	STK4	1	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	6
RASSF5	2	MAP1B	5	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Hauri S (2013)	2
MAP1LC3A	0	RASSF5	2	affinity chromatography technology	Behrends C (2010)	1
RASSF1	3	STK3	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Guo C (2007), Guo C (2007), Liu L (2007), Matallanas D (2007), Romano D (2010), Romano D (2010), Couzens AL (2013), Varjosalo M (2013), Fenton SL (2004), Huttlin EL (2015), Hauri S (2013), Hauri S (2013), Huttlin EL (2017), Ivanov AA (2017)	14
SRPK2	1	MAP1S	3	enzymatic study	Lipp JJ (2015)	1
FKBP3	0	HNRNPA2B1	2	biochemical	Kristensen AR (2012)	1
ATG3	4	MAP1B	5	affinity chromatography technology	Behrends C (2010)	1
FBXW11	2	RASSF1	3	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015)	2
ATM	9	MAP1S	3	two hybrid	Arroyo R (2015)	1
GGA1	0	MAP1S	3	affinity chromatography technology	Huttlin EL (2017)	1
DBF4B	1	MAP1S	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRPK2	1	DBF4B	1	enzymatic study	Varjosalo M (2013)	1
HECW2	13	ANXA1	1	affinity chromatography technology	Lu L (2013)	1
STK3	1	MAP1S	3	bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	4
MAP1LC3A	0	STK4	1	affinity chromatography technology	Behrends C (2010)	1
SOCS3	0	MAP1S	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Zou T (2008), Zou T (2008), Zou T (2008)	3
MAP1S	3	STIP1	1	affinity chromatography technology	Hauri S (2013)	1
RASSF3	2	MAP1B	5	affinity chromatography technology	Hauri S (2013)	1
RASSF5	2	RASSF1	3	pull down, affinity chromatography technology	Ortiz-Vega S (2002), Ortiz-Vega S (2002)	2
STK4	1	RASSF1	3	affinity chromatography technology, two hybrid, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Behrends C (2010), Liu L (2007), Couzens AL (2013), Varjosalo M (2013), Huttlin EL (2015), Hauri S (2013), Hauri S (2013), Mo XL (2015), Huttlin EL (2017), Ivanov AA (2017)	10
PPM1G	1	MAP1S	3	affinity chromatography technology	Yadav L (2017)	1
NTRK1	1	STIP1	1	affinity chromatography technology	Emdal KB (2015)	1
FBXW11	2	LRPPRC	7	affinity chromatography technology	Low TY (2014)	1
LIPH	1	MAP1S	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BPY2	0	MAP1S	3	two hybrid, pull down	Wong EY (2004), Wong EY (2004)	2
MAP1S	3	ANXA2	0	affinity chromatography technology	Hauri S (2013)	1
MAP1S	3	HNRNPA2B1	2	biochemical	Kristensen AR (2012)	1
STK4	1	MAP1B	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Varjosalo M (2013), Hauri S (2013)	3
MAP1S	3	SYNCRIP	6	biochemical	Kristensen AR (2012)	1
NTRK1	1	DCTN1	6	affinity chromatography technology	Emdal KB (2015)	1
FBXW11	2	STK4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014)	4
MAP1LC3A	0	MAP1B	5	affinity chromatography technology	Behrends C (2010)	1
STK3	1	STK4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, fluorescent resonance energy transfe	Behrends C (2010), Behrends C (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013), Wan C (2015), Ivanov AA (2017)	12
RASSF5	2	MAP1S	3	affinity chromatography technology, two hybrid, affinity chromatography technology	Behrends C (2010), Rolland T (2014), Hauri S (2013)	3
DCTN1	6	MAP1S	3	bioid	Gupta GD (2015)	1
NTRK1	1	MAP1B	5	affinity chromatography technology	Emdal KB (2015)	1
LRPPRC	7	MAP1S	3	two hybrid	Liu L (2002)	1
ATG3	4	MAP1S	3	affinity chromatography technology	Huttlin EL (2017)	1
MAP1S	3	567	0	affinity chromatography technology	Hauri S (2013)	1
NTRK1	1	PPM1G	1	affinity chromatography technology	Emdal KB (2015)	1
STK3	1	MAP1B	5	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Hauri S (2013)	2
STK3	1	RASSF3	2	bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	4
BTRC	1	STK4	1	affinity chromatography technology, bioid, affinity chromatography technology	Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	3
ATM	9	RASSF1	3	unspecified method	Kim ST (1999)	1
NLGN3	3	MAP1S	3	two hybrid	Shen C (2015)	1
NTRK1	1	HNRNPA2B1	2	affinity chromatography technology	Emdal KB (2015)	1
FBXW11	2	HNRNPA2B1	2	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014)	2
DBF4B	1	MAP1B	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP1S	3	RASSF1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu L (2005), Dallol A (2004), Dallol A (2004), Huttlin EL (2015), Hauri S (2013), Huttlin EL (2017)	6
STK4	1	MAP1S	3	bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	4
HECW2	13	MAP1S	3	affinity chromatography technology	Lu L (2013)	1
MAP1S	3	RASSF3	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Hauri S (2013)	2
MAP1LC3A	0	STK3	1	affinity chromatography technology	Behrends C (2010)	1
FAM174A	2	MAP1S	3	affinity chromatography technology	Huttlin EL (2017)	1
FBXW11	2	SYNCRIP	6	affinity chromatography technology	Coyaud E (2015)	1
NTRK1	1	LRPPRC	7	affinity chromatography technology	Emdal KB (2015)	1
FGL1	3	MAP1S	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2