PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
CUL5	1	ELOC	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kamura T (2001), Nishiya T (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Kershaw NJ (2014), Huttlin EL (2017)	18
PCGF1	1	PCMTD2	0	affinity chromatography technology	Oliviero G (2015)	1
PCGF1	1	DPPA4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Oliviero G (2015), Oliviero G (2015), Oliviero G (2015), Oliviero G (2015), Oliviero G (2015)	5
ATP13A2	1	PCMTD2	0	two hybrid	Usenovic M (2012)	1
POU5F1	0	PCMTD2	0	affinity chromatography technology	Oliviero G (2015)	1
POU5F1	0	PCGF1	1	affinity chromatography technology	Oliviero G (2015)	1
CUL5	1	ELOB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Kamura T (2001), Nie L (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Antonioli M (2014), Kershaw NJ (2014)	18
TRIP13	0	PCMTD2	0	two hybrid	Rolland T (2014)	1
PCMTD2	0	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008), Bennett EJ (2010), Huttlin EL (2017)	4
POU5F1	0	DPPA4	0	affinity chromatography technology	Oliviero G (2015)	1
DPPA4	0	ELOC	0	affinity chromatography technology	Oliviero G (2015)	1
ELOC	0	PCMTD2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008), Mahrour N (2008)	3
DPPA4	0	TRIP13	0	affinity chromatography technology	Oliviero G (2015)	1
AUP1	0	PCMTD2	0	affinity chromatography technology	Huttlin EL (2015)	1
NANOG	0	PCMTD2	0	affinity chromatography technology	Oliviero G (2015)	1
BRCA1	7	CUL2	3	affinity chromatography technology	Ertych N (2016)	1
PCGF1	1	NANOG	0	biochemical, affinity chromatography technology	Oliviero G (2015), Oliviero G (2015)	2
POU5F1	0	TRIP13	0	affinity chromatography technology	Oliviero G (2015)	1
BRCA1	7	PCMTD2	0	affinity chromatography technology	Ertych N (2016)	1
CUL2	3	ELOB	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kamura T (2001), Menon S (2008), Megumi Y (2005), Kamura T (2002), Brower CS (2002), Bennett EJ (2010), Pause A (1997), Kamura T (2004), Kelsall IR (2013)	9
POU5F1	0	ELOC	0	affinity chromatography technology	Oliviero G (2015)	1
MRPS11	1	PCMTD2	0	affinity chromatography technology	Huttlin EL (2015)	1
CUL2	3	ELOC	0	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Kamura T (2001), Maine GN (2007), Megumi Y (2005), Mao X (2009), Lonergan KM (1998), Lonergan KM (1998), Bennett EJ (2010), Pause A (1997), Pause A (1999), Kamura T (2004), Kelsall IR (2013), Lee SB (2016)	12
PCMTD2	0	VAC14	5	two hybrid	Rolland T (2014)	1
PCGF1	1	ELOC	0	affinity chromatography technology	Oliviero G (2015)	1
NANOG	0	ELOC	0	affinity chromatography technology	Oliviero G (2015)	1
CUL5	1	CUL2	3	affinity chromatography technology	Bennett EJ (2010)	1
DPPA4	0	PCMTD2	0	affinity chromatography technology	Oliviero G (2015)	1
PCMTD2	0	CUL2	3	affinity chromatography technology	Mahrour N (2008)	1
SEPT3	1	PCMTD2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELOB	1	PCMTD2	0	affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008)	2