Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
PPP3CA	5530	MYRISTIC ACID	CHEMBL111077		DrugBank	10592235
PPP3CA	5530	VOCLOSPORIN	CHEMBL2218919		TdgClinicalTrial

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
PPP3CA	rs3730251	CT + TT	tacrolimus	metabolism/PK	no	No association was found between this variant and dose, concentration or dose-adjusted concentration of tacrolimus. The authors do not show the data underlying these results in the paper. Please note that alleles have been complemented to the plus chromosomal strand.	Genotypes CT + TT is not associated with exposure to tacrolimus in people with Kidney Transplantation as compared to genotype CC.	28435308	1448819442
PPP3CA	rs3730251	CT + TT	tacrolimus	"efficacy","toxicity"	no	This variant did not influence clinical outcomes of patients receiving tacrolimus, including eGFR, levels of urea, creatinine, glucose, lipids, or blood counts, biopsy-confirmed acute rejection, delayed graft function, renal function, or adverse events. The authors note that those with the CT or TT genotype did have a 3.05-fold increased probability of treatment-induced blood and lymphatic system disorders as compared to the CC genotype, but this result was not maintained after adjusting for body weight and CYP3A5*3 status. Please note that alleles have been complemented to the plus chromosomal strand.	Genotypes CT + TT are not associated with response to tacrolimus in people with Kidney Transplantation as compared to genotype CC.	28435308	1448819433