PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BLOC1S6	0	SNAPIN	1	biochemical, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004)	2
DTNBP1	1	BLOC1S4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BLOC1S4	2	SNAPIN	1	two hybrid	Starcevic M (2004)	1
EXOC1	3	BLOC1S2	0	affinity chromatography technology	Huttlin EL (2017)	1
BLOC1S6	0	BLOC1S4	2	two hybrid, two hybrid	Starcevic M (2004), Starcevic M (2004)	2
WASHC3	2	DTNBP1	1	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
EXOC1	3	BLOC1S4	2	affinity chromatography technology	Huttlin EL (2017)	1
BLOC1S4	2	BLOC1S2	0	two hybrid, two hybrid	Starcevic M (2004), Starcevic M (2004)	2
BLOC1S2	0	SNAPIN	1	affinity chromatography technology, two hybrid, two hybrid, biochemical	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004), Wan C (2015)	4
POC1B	2	BLOC1S4	2	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	BLOC1S4	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	DTNBP1	1	affinity chromatography technology	Kirli K (2015)	1
WASHC3	2	BLOC1S4	2	affinity chromatography technology	Huttlin EL (2017)	1
WASHC3	2	POC1B	2	affinity chromatography technology	Huttlin EL (2017)	1
BLOC1S6	0	DTNBP1	1	biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004), Huttlin EL (2015), Huttlin EL (2017)	5
EXOC1	3	SNAPIN	1	affinity chromatography technology	Huttlin EL (2017)	1
DTNBP1	1	SNAPIN	1	affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
AIMP2	0	BLOC1S4	2	two hybrid	Vinayagam A (2011)	1
BLOC1S6	0	BLOC1S2	0	biochemical, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004)	3
BLOC1S6	0	WASHC3	2	two hybrid	Rual JF (2005)	1
WASHC3	2	BLOC1S2	0	affinity chromatography technology	Huttlin EL (2017)	1
DTNBP1	1	EXOC1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DTNBP1	1	BLOC1S2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Huttlin EL (2015), Huttlin EL (2017)	3