PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PIDD1	5	PRDX1	1	affinity chromatography technology	Logette E (2011)	1
KEAP1	0	PIDD1	5	two hybrid	Wang J (2011)	1
PIDD1	5	DDB1	6	affinity chromatography technology	Logette E (2011)	1
EFEMP2	0	PIDD1	5	two hybrid	Rual JF (2005)	1
CRYAB	0	CCDC85B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLR2B	3	IKBKG	0	two hybrid	Ravasi T (2010)	1
RIPK1	2	FADD	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen D (2002), Young JA (2011), Tenev T (2011), Ramakrishnan P (2011), Legarda-Addison D (2009), ODonnell MA (2012), Vanlangenakker N (2011), Biton S (2011), Biton S (2011), Lee EW (2012), Puliyappadamba VT (2013), Wu P (2014), Huttlin EL (2015), Baratchian M (2016), Moquin DM (2013), Ranjan K (2016), Pescatore A (2016), Zheng M (2016)	18
IKBKG	0	MCM7	5	pull down	Fenner BJ (2010)	1
PCNA	0	RFC4	1	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Cai J (1997), Ohta S (2002), Ohta S (2002), Havugimana PC (2012), Han J (2014), Hein MY (2015)	6
MTNR1B	1	PRKDC	12	two hybrid	Benleulmi-Chaachoua A (2016)	1
IKBKG	0	RPAP3	1	pull down, affinity chromatography technology	Fenner BJ (2010), Shimada K (2011)	2
PIDD1	5	RFC4	1	affinity chromatography technology	Logette E (2011)	1
PIDD1	5	POLR2B	3	affinity chromatography technology	Logette E (2011)	1
SENP3	1	TELO2	6	affinity chromatography technology	Wang M (2016)	1
PIDD1	5	TEAD3	0	two hybrid	Wang J (2011)	1
TELO2	6	RPAP3	1	affinity chromatography technology	Takai H (2010)	1
SENP3	1	MCM7	5	affinity chromatography technology	Wang M (2016)	1
CRADD	0	CRYAB	0	affinity chromatography technology	Jeong WJ (2012)	1
PIDD1	5	AIFM1	1	affinity chromatography technology	Logette E (2011)	1
PIDD1	5	HAX1	1	affinity chromatography technology	Logette E (2011)	1
DDB1	6	PCNA	0	affinity chromatography technology	Angers S (2006)	1
PIDD1	5	RPAP3	1	affinity chromatography technology	Logette E (2011)	1
PIDD1	5	MADD	8	affinity chromatography technology	Telliez JB (2000)	1
PCNA	0	POLD1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Ohta S (2002), Naryzhny SN (2005), Naryzhny SN (2004), Ogi T (2010), Shikata K (2001), Shikata K (2001), Xie B (2002), Li H (2006), Park JM (2014), Han J (2014), Hein MY (2015)	11
TELO2	6	PRKDC	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaizuka T (2010), Takai H (2010), Takai H (2010), Takai H (2007), Takai H (2007)	5
ERCC5	0	ERCC2	4	affinity chromatography technology, pull down	Iyer N (1996), Iyer N (1996)	2
PIDD1	5	SOX8	4	two hybrid	Wang J (2011)	1
MTNR1B	1	FANCI	1	two hybrid	Benleulmi-Chaachoua A (2016)	1
PIDD1	5	TELO2	6	affinity chromatography technology	Logette E (2011)	1
PIDD1	5	SENP3	1	affinity chromatography technology	Logette E (2011)	1
PIDD1	5	POLD1	5	affinity chromatography technology	Logette E (2011)	1
PIDD1	5	TRIM32	2	affinity chromatography technology	Logette E (2011)	1
PIDD1	5	CRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tinel A (2004), Janssens S (2005), Logette E (2011), Jeong WJ (2012)	4
CCDC85B	0	PIDD1	5	two hybrid	Rual JF (2005)	1
SENP3	1	NUP93	5	affinity chromatography technology	Wang M (2016)	1
PCNA	0	PRKDC	12	affinity chromatography technology	Ohta S (2002)	1
AFP	1	PIDD1	5	two hybrid	Wang J (2011)	1
MTNR1B	1	PIDD1	5	two hybrid	Benleulmi-Chaachoua A (2016)	1
RPAP3	1	POLR2B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Jeronimo C (2007), Cloutier P (2017)	3
PIDD1	5	RIPK1	2	affinity chromatography technology	Janssens S (2005)	1
PIDD1	5	ANP32B	0	affinity chromatography technology	Logette E (2011)	1
RIPK1	2	CRADD	0	pull down, pull down	Ahmad M (1997), Duan H (1997)	2
PIDD1	5	FANCI	1	affinity chromatography technology	Logette E (2011)	1
CASP2	1	PIDD1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tinel A (2004), Janssens S (2005), Logette E (2011)	3
PIDD1	5	FADD	1	affinity chromatography technology, affinity chromatography technology	Telliez JB (2000), Janssens S (2005)	2
PIDD1	5	PRKDC	12	affinity chromatography technology	Logette E (2011)	1
PIDD1	5	PPP6C	7	affinity chromatography technology	Logette E (2011)	1
PCNA	0	RFC5	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Cai J (1997), Mossi R (1997), Ohta S (2002), Han J (2014)	4
IKBKG	0	FADD	1	affinity chromatography technology	Biton S (2011)	1
PIDD1	5	CRYAB	0	affinity chromatography technology	Jeong WJ (2012)	1
MDFI	1	PIDD1	5	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
ERCC5	0	PCNA	0	pull down	Gary R (1997)	1
PIDD1	5	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Logette E (2011), Logette E (2011), Logette E (2011)	3
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
PIDD1	5	MCM7	5	affinity chromatography technology	Logette E (2011)	1
RPAP3	1	RFC5	2	affinity chromatography technology	Jeronimo C (2007)	1
PIDD1	5	ERCC5	0	affinity chromatography technology	Logette E (2011)	1
PIDD1	5	NUP93	5	affinity chromatography technology	Logette E (2011)	1
PIDD1	5	MAFG	1	two hybrid	Wang J (2011)	1
PIDD1	5	RFC5	2	affinity chromatography technology, affinity chromatography technology	Logette E (2011), Logette E (2011)	2
PIDD1	5	ERCC2	4	affinity chromatography technology	Logette E (2011)	1
PRKDC	12	PPP6C	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Douglas P (2010), Douglas P (2010), Douglas P (2010), Couzens AL (2013), Yadav L (2017)	5
PRKDC	12	PRDX1	1	biochemical	Kristensen AR (2012)	1
PCNA	0	MCM7	5	affinity chromatography technology	Han J (2014)	1
RFC4	1	RFC5	2	two hybrid, biochemical, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, affinity chromatography technology	Rual JF (2005), Cai J (1997), Cai J (1998), Ellison V (1998), Havugimana PC (2012), Uhlmann F (1997), Rolland T (2014), Wan C (2015), Huttlin EL (2017)	9
CASP2	1	CRADD	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology, two hybrid	Tinel A (2004), Droin N (2000), Droin N (2000), Duan H (1997), Duan H (1997), Duan H (1997), Jeong WJ (2012), Rolland T (2014)	8
CASP2	1	CRYAB	0	affinity chromatography technology	Jeong WJ (2012)	1
PIDD1	5	IKBKG	0	affinity chromatography technology	Janssens S (2005)	1