Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
PRCP rs2229437 GG + GT benazepril efficacy yes Carriers of the G allele had a lower reduction in systolic blood pressure (SBP) and diastolic blood pressure (DBP) and a lower likelihood of reaching target blood pressure (SBP < 140 mmHg and DBP < 90 mmHg) between baseline and 15 days of treatment, as compared to TT homozygotes. Please note alleles have been complemented to the plus chromosomal strand. Genotypes GG + GT are associated with decreased response to benazepril in people with Hypertension as compared to genotype TT. 20079160 1183615597