PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SOX6	1	TRIP12	20	two hybrid, affinity chromatography technology, enzymatic study	An CI (2013), An CI (2013), An CI (2013)	3
SOX6	1	HDAC1	4	affinity chromatography technology, pull down	Iguchi H (2007), Iguchi H (2007)	2
CTNNB1	30	SOX6	1	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Iguchi H (2007), Iguchi H (2007), Iguchi H (2007), Iguchi H (2007)	4
UBE2I	0	HDAC1	4	enzymatic study	Citro S (2013)	1
CTNNB1	30	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vietor I (2005), Billin AN (2000), Iguchi H (2007), Iioka H (2009)	4
SOX2	4	SOX5	11	affinity chromatography technology	Engelen E (2011)	1
SOX2	4	CTBP2	7	affinity chromatography technology	Engelen E (2011)	1
CTBP2	7	UBE2I	0	two hybrid	Wang J (2011)	1
SOX2	4	SOX6	1	affinity chromatography technology	Cox JL (2013)	1
CENPK	0	SOX6	1	two hybrid, pull down	Yamashita A (2000), Yamashita A (2000)	2
POMGNT1	1	SOX6	1	two hybrid	Wang J (2011)	1
SOX2	4	HDAC1	4	affinity chromatography technology	Engelen E (2011)	1
SOX6	1	CTBP2	7	two hybrid, affinity chromatography technology	Murakami A (2001), Murakami A (2001)	2
SOX5	11	SOX6	1	affinity chromatography technology	Huttlin EL (2017)	1
SOX2	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cox JL (2013), Xu C (2013), Xu C (2013)	3
UBE2I	0	SOX6	1	enzymatic study	Fernandez-Lloris R (2006)	1
SOX6	1	ZNF184	1	two hybrid	Wang J (2011)	1
SOX6	1	TAF4	4	affinity chromatography technology	Cimadamore F (2013)	1