PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DOK4	3	PHKA2	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	HMG20A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	PTK2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	GSE1	14	affinity chromatography technology	Abdelmohsen K (2009)	1
DOK4	3	RET	3	affinity chromatography technology	Grimm J (2001)	1
DOK4	3	RCOR1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DOK4	3	CCM2	2	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
EGFR	5	MIER1	2	affinity chromatography technology	Yao Z (2017)	1
ELAVL1	0	RCOR3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PTK2	2	RET	3	imaging technique	Chen TC (2014)	1
EGFR	5	SUPT5H	2	affinity chromatography technology	Yao Z (2017)	1
DOK4	3	KBTBD6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BAG3	4	DOK4	3	affinity chromatography technology	Chen Y (2013)	1
DOK4	3	AHCYL1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KBTBD7	3	KBTBD6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Genau HM (2015), Genau HM (2015), Hein MY (2015), Huttlin EL (2017)	5
DOK4	3	RCOR3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DOK4	3	KDM1A	2	affinity chromatography technology	Huttlin EL (2015)	1
DOK4	3	DOK3	5	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
DOK4	3	SUPT4H1	1	affinity chromatography technology	Huttlin EL (2017)	1
KDM1A	2	RCOR3	0	affinity chromatography technology, two hybrid, biochemical	Bantscheff M (2011), Weimann M (2013), Wan C (2015)	3
RHOU	0	DOK4	3	pull down	Dart AE (2015)	1
PHKG2	2	PHKB	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
HMG20A	0	GSE1	14	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
4985	0	DOK4	3	affinity chromatography technology	Petko J (2013)	1
DOK4	3	MIER1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
EGFR	5	DOK4	3	unspecified method	Jones RB (2006)	1
HMG20A	0	RCOR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Rivero S (2015)	4
DOK4	3	GSE1	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DOK4	3	OLIG1	0	two hybrid	Grossmann A (2015)	1
PTK2	2	ERBB2	6	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), Ritch PA (2003), Ritch PA (2003)	3
DOK4	3	ANK3	16	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GSE1	14	RCOR3	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
KDM1A	2	HMG20A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shi YJ (2005), Bantscheff M (2011), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Rivero S (2015)	6
EGFR	5	STAT2	2	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
DOK4	3	PTK2	2	two hybrid	Grossmann A (2015)	1
DOK4	3	SUPT5H	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DOK4	3	HMG20A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DOK4	3	AHCYL2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PTK2	2	EGFR	5	affinity chromatography technology, two hybrid, protein complementation assay	Sieg DJ (2000), Kotlyar M (2015), Petschnigg J (2014)	3
DOK4	3	CWC22	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	RET	3	two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Bhinge K (2017), Bhinge K (2017)	4
DOK4	3	STAT2	2	two hybrid	Grossmann A (2015)	1
AHCYL2	4	AHCYL1	2	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	STAT2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
DOK4	3	PHKG2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DOK4	3	FHL2	0	affinity chromatography technology	Huttlin EL (2017)	1
DOK4	3	SMARCAD1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OPRM1	0	4985	0	affinity chromatography technology, affinity chromatography technology	Gomes I (2000), He SQ (2011)	2
SUPT5H	2	SUPT4H1	1	affinity chromatography technology, x-ray crystallography, biochemical, pull down, biochemical, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Kwak YT (2003), Wenzel S (2010), Kim DK (2003), Kim DK (2003), Havugimana PC (2012), Yamaguchi Y (1999), Yamaguchi Y (1999), Wan C (2015), Hein MY (2015)	9
ERBB2	6	DOK4	3	unspecified method	Jones RB (2006)	1
DOK4	3	KBTBD7	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMARCAD1	1	KDM1A	2	affinity chromatography technology	Rowbotham SP (2011)	1
OPRM1	0	DOK4	3	two hybrid, pull down, pull down, affinity chromatography technology	Petko J (2013), Petko J (2013), Petko J (2013), Petko J (2013)	4
EGFR	5	KBTBD7	3	affinity chromatography technology	Yao Z (2017)	1
HMG20A	0	RCOR3	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
RCOR1	0	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Gocke CB (2008), Chen Y (2006), Yang M (2006), Shi YJ (2005), Shi YJ (2005), Lee MG (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Hwang S (2011), Lin Y (2010), Nicholson TB (2011), Nicholson TB (2011), Cui S (2011), Adamo A (2011), Adamo A (2011), Bantscheff M (2011), Mosammaparast N (2013), Lin Y (2010), Wan C (2015), Boldt K (2016)	25
DOK4	3	MAPRE3	0	two hybrid	Grossmann A (2015)	1
DOK4	3	LIX1	1	two hybrid	Grossmann A (2015)	1
ELAVL1	0	MIER1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
DOK4	3	PBK	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DOK4	3	PHKB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DOK4	3	RBP7	3	two hybrid	Grossmann A (2015)	1
PHKG2	2	PHKA2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Hein MY (2015), Huttlin EL (2017)	3
KDM1A	2	GSE1	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Lee MG (2005), Bantscheff M (2011)	3
ELAVL1	0	AHCYL1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
OPRK1	1	DOK4	3	affinity chromatography technology	Petko J (2013)	1
ELAVL1	0	DOK4	3	affinity chromatography technology	Abdelmohsen K (2009)	1