Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
PRKCA	5578	VITAMIN E	CHEMBL47		DrugBank	11850093, 17139284, 17016423, 9430404, 11736999
PRKCA	5578	ELLAGIC ACID	CHEMBL6246	inhibitor, competitive	DrugBank	9581512
PRKCA	5578	APRINOCARSEN SODIUM	CHEMBL2108985	antisense oligonucleotide	TALC
PRKCA	5578	RUBOXISTAURIN	CHEMBL91829	inhibitor	GuideToPharmacologyInteractions
PRKCA	5578	MIDOSTAURIN	CHEMBL608533	inhibitor	MyCancerGenome, ChemblInteractions
PRKCA	5578	BRYOSTATIN	CHEMBL449158		TdgClinicalTrial
PRKCA	5578	CEP-2563	CHEMBL3545332	inhibitor	ChemblInteractions
PRKCA	5578	(7S)-HYDROXYL-STAUROSPORINE	CHEMBL574737	inhibitor	ChemblInteractions
PRKCA	5578	GO-6976	CHEMBL302449	inhibitor	GuideToPharmacologyInteractions
PRKCA	5578	SEBACIC ACID	CHEMBL1232164	inhibitor	GuideToPharmacologyInteractions
PRKCA	5578	SOTRASTAURIN	CHEMBL565612	inhibitor	GuideToPharmacologyInteractions, ChemblInteractions
PRKCA	5578	QUERCETIN	CHEMBL50	inhibitor	MyCancerGenome
PRKCA	5578	SOTRASTAURIN ACETATE	CHEMBL2105655	inhibitor	TTD
PRKCA	5578	GSK-690693	CHEMBL494089	inhibitor	ChemblInteractions
PRKCA	5578	DEXFOSFOSERINE	CHEMBL284377		DrugBank	16114872, 12269833, 14698304, 17367165
PRKCA	5578	CHEMBL1236539	CHEMBL1236539	inhibitor	GuideToPharmacologyInteractions
PRKCA	5578	BALANOL	CHEMBL60254	inhibitor	GuideToPharmacologyInteractions
PRKCA	5578	ENZASTAURIN	CHEMBL300138	inhibitor	MyCancerGenome, GuideToPharmacologyInteractions
PRKCA	5578	TAMOXIFEN	CHEMBL83		DrugBank	3157445
PRKCA	5578	INGENOL MEBUTATE	CHEMBL1863513	activator, ligand	TdgClinicalTrial, GuideToPharmacologyInteractions, DrugBank	15126366

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
PRKCA	rs9303504	G	Ace Inhibitors, Plain	efficacy	no	The authors note that this variant was in strong LD with rs9909004.	Allele G is not associated with response to Ace Inhibitors, Plain, Angiotensin II Antagonists or Beta Blocking Agents in people with Heart Failure as compared to allele C.	31728800	1451133423
PRKCA	rs9909004	C	Ace Inhibitors, Plain	efficacy	no	The authors note that this variant was in strong LD with rs9303504.	Allele C is not associated with response to Ace Inhibitors, Plain, Angiotensin II Antagonists or Beta Blocking Agents in people with Heart Failure as compared to allele T.	31728800	1451133400
PRKCA	rs4791040	T	diuretics	efficacy	yes	The association was with diastolic blood pressure response. It did not reach genome-wide significance when only PEAR + GERA were analyzed, but this SNP was selected for replication in NORDIL and this association was significant. Observations: 4.46 mm Hg decreased reduction of diastolic blood pressure per T allele in PEAR + GERA, 3.30 mm Hg decreased reduction of diastolic blood pressure per T allele in NORDIL, and 4.17 mm Hg decreased reduction of diastolic blood pressure per T allele in PEAR + GERA + NORDIL.	Allele T is associated with decreased response to diuretics, hydrochlorothiazide or Thiazides, plain in people with Hypertension as compared to allele C.	23753411	1183632057
PRKCA	rs16960228	A	diuretics	efficacy	yes	Observations: 4.46 mm Hg increased reduction of diastolic blood pressure per A allele in PEAR + GERA, 3.26 mm Hg increased reduction of diastolic blood pressure per A allele in NORDIL, and 4.16 mm Hg increased reduction of diastolic blood pressure per A allele in PEAR + GERA + NORDIL.The association did not reach genome-wide significance when only PEAR + GERA were analyzed, but this SNP was selected for replication in NORDIL and here the association reached significance. It did not reach genome-wide significance in the meta-analysis of PEAR + GERA + NORDIL. It was then tested for replication in the GENRES and Milan cohorts, reaching significance in GENRES but not in the Milan cohort.	Allele A is associated with increased response to diuretics, hydrochlorothiazide or Thiazides, plain in people with Hypertension as compared to allele G.	23753411	1183631253