Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
PRKCE	5581	INGENOL MEBUTATE	CHEMBL1863513	activator	TdgClinicalTrial, GuideToPharmacologyInteractions
PRKCE	5581	(7S)-HYDROXYL-STAUROSPORINE	CHEMBL574737	inhibitor	ChemblInteractions
PRKCE	5581	MEPROBAMATE	CHEMBL979	activator	TdgClinicalTrial, DrugBank, TTD
PRKCE	5581	CHELERYTHRINE	CHEMBL13045	inhibitor	GuideToPharmacologyInteractions
PRKCE	5581	SOTRASTAURIN	CHEMBL565612	inhibitor	GuideToPharmacologyInteractions, ChemblInteractions
PRKCE	5581	Y-27632	CHEMBL559147	inhibitor	GuideToPharmacologyInteractions
PRKCE	5581	BRYOSTATIN	CHEMBL449158		TdgClinicalTrial
PRKCE	5581	CEP-2563	CHEMBL3545332	inhibitor	ChemblInteractions
PRKCE	5581	BALANOL	CHEMBL60254	inhibitor	GuideToPharmacologyInteractions
PRKCE	5581	GSK-690693	CHEMBL494089	inhibitor	ChemblInteractions
PRKCE	5581	ENZASTAURIN	CHEMBL300138	inhibitor	MyCancerGenome
PRKCE	5581	QUERCETIN	CHEMBL50	inhibitor	MyCancerGenome
PRKCE	5581	CHEMBL1236539	CHEMBL1236539	inhibitor	GuideToPharmacologyInteractions
PRKCE	5581	MIDOSTAURIN	CHEMBL608533	inhibitor	ChemblInteractions

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
PRKCE	rs2278773	C	perphenazine	efficacy	yes	as measured by changes in PANSS-T (positive and negative syndrome scale total score), using a mixed model repeated measures approach. Examined 6789 SNPs - p-value of p< or equal to 5x10-4 was considered significant. It was unclear whether the allele was associated with an increased or decreased response to drug.	Allele C is associated with response to perphenazine in people with Schizophrenia.	22920393	981238707
PRKCE	rs6720975	T	donepezil	efficacy	yes	The study contained a discovery sample and a replication sample, and also did a meta-analysis of the two samples together. Response is defined as patients whose mini-mental state examination (MMSE) points increased, remained stable, or the change in MMSE points between baseline and end of follow-up (deltaMMSE) fell by 1 point or less. Non-responders were defined as worsening of >3 points on the MMSE. Patients had been treated with cholinesterase inhibitors for at least 6 months. The study also assessed the influence of the SNP on deltaMMSE. Please note alleles have been complemented to the plus chromosomal strand, and that this SNP did NOT reach genome-wide significance in any of the samples.	Allele T is associated with increased response to donepezil, galantamine and rivastigmine in people with Alzheimer Disease as compared to allele C.	23374588	1183703663