PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF2	1	HDAC2	1	affinity chromatography technology	Cao Q (2014)	1
ELAVL1	0	NFYC	0	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF2	1	SMC3	16	affinity chromatography technology	Cao Q (2014)	1
GTF3C1	11	GTF3C3	2	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
UBR5	13	RNF2	1	imaging technique	Sanchez A (2016)	1
NRF1	2	POGZ	49	two hybrid	Rolland T (2014)	1
FOXJ2	3	DNTTIP1	0	affinity chromatography technology	Li X (2015)	1
FOXC1	0	GATAD2B	15	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	ZNF644	6	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	NRF1	2	affinity chromatography technology	Li X (2015)	1
CHD4	22	GATAD2B	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rahman S (2011), Huttlin EL (2015), Huttlin EL (2017)	3
EGLN3	0	GTF3C3	2	affinity chromatography technology	Rodriguez J (2016)	1
MAGEA10	1	SATB2	18	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC2	1	EMSY	3	affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Varier RA (2016)	2
HIC2	3	APP	1	pull down	Olah J (2011)	1
RFX3	7	HDAC2	1	affinity chromatography technology	Boldt K (2016)	1
FOXJ2	3	GATAD2B	15	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	BBX	2	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	SALL1	2	affinity chromatography technology	Li X (2015)	1
TBP	0	NFYC	0	pull down	Bellorini M (1997)	1
FOXJ2	3	KDM5C	9	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	TRPS1	5	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	ZMYM4	4	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	ADNP	37	affinity chromatography technology	Li X (2015)	1
KDM5C	9	RNF2	1	affinity chromatography technology	Tahiliani M (2007)	1
FOXJ2	3	POU2F2	2	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	GTF3C3	2	affinity chromatography technology	Li X (2015)	1
ZNF644	6	ZMYM2	5	affinity chromatography technology	Hein MY (2015)	1
FOXJ2	3	EGLN3	0	two hybrid	Rolland T (2014)	1
FOXJ2	3	USF2	3	affinity chromatography technology	Li X (2015)	1
ELAVL1	0	AKAP8	1	affinity chromatography technology	Abdelmohsen K (2009)	1
EGLN3	0	GTSE1	3	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	EYA4	1	affinity chromatography technology	Rodriguez J (2016)	1
NR3C1	2	HDAC2	1	affinity chromatography technology	Ito K (2000)	1
FOXJ2	3	APP	1	pull down	Olah J (2011)	1
FOXJ2	3	SMC1A	15	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	EYA4	1	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	RNF2	1	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	FOXF2	1	affinity chromatography technology	Li X (2015)	1
ZMYND8	5	HDAC2	1	affinity chromatography technology	Hein MY (2015)	1
EMSY	3	QSER1	7	affinity chromatography technology	Varier RA (2016)	1
FOXJ2	3	ESS2	0	affinity chromatography technology	Li X (2015)	1
KDM5C	9	ZMYND8	5	affinity chromatography technology	Hein MY (2015)	1
FOXJ2	3	FOXC1	0	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	YY1	7	affinity chromatography technology	Li X (2015)	1
EGLN3	0	YY1	7	affinity chromatography technology	Rodriguez J (2016)	1
FOXJ2	3	MECOM	4	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	ZNF148	4	affinity chromatography technology	Li X (2015)	1
RNF2	1	YY1	7	affinity chromatography technology, affinity chromatography technology	Lorente M (2006), Cao Q (2014)	2
RNF2	1	GTF3C4	0	affinity chromatography technology	Cao Q (2014)	1
FOXJ2	3	NFYC	0	affinity chromatography technology	Li X (2015)	1
GABPA	0	APP	1	pull down	Olah J (2011)	1
ZNF131	0	RBM22	0	affinity chromatography technology	Varier RA (2016)	1
MAGEA10	1	NCOA2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
TBP	0	GTF3C3	2	pull down	Hsieh YJ (1999)	1
FOXJ2	3	MAD1L1	2	affinity chromatography technology	Li X (2015)	1
POGZ	49	ZMYM4	4	affinity chromatography technology	Vermeulen M (2010)	1
FOXJ2	3	PATZ1	1	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	POGZ	49	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	UBR5	13	affinity chromatography technology	Li X (2015)	1
TBP	0	GTF3C4	0	pull down	Hsieh YJ (1999)	1
FOXJ2	3	HOXC13	0	affinity chromatography technology	Li X (2015)	1
EGLN3	0	UBR5	13	affinity chromatography technology	Rodriguez J (2016)	1
ELAVL1	0	MECOM	4	affinity chromatography technology	Abdelmohsen K (2009)	1
FOXJ2	3	KLF16	1	affinity chromatography technology	Li X (2015)	1
MAD1L1	2	HDAC2	1	biochemical, affinity chromatography technology	Yoon YM (2004), Yoon YM (2004)	2
L3MBTL2	1	GATAD2B	15	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	HIC2	3	affinity chromatography technology	Rodriguez J (2016)	1
RNF2	1	GTF3C1	11	affinity chromatography technology	Cao Q (2014)	1
NFYC	0	POGZ	49	two hybrid	Bandyopadhyay S (2010)	1
FOXJ2	3	RFX2	5	affinity chromatography technology	Li X (2015)	1
FOXC1	0	SATB2	18	affinity chromatography technology	Li X (2015)	1
ELAVL1	0	FOXJ2	3	affinity chromatography technology	Abdelmohsen K (2009)	1
EGLN3	0	ESS2	0	affinity chromatography technology	Rodriguez J (2016)	1
TBP	0	NR3C1	2	pull down	Almloef T (1998)	1
ELAVL1	0	SATB2	18	affinity chromatography technology	Abdelmohsen K (2009)	1
FOXJ2	3	AKAP8	1	affinity chromatography technology	Li X (2015)	1
GTF3C4	0	GTF3C1	11	affinity chromatography technology, pull down, biochemical	Hsieh YJ (1999), Hsieh YJ (1999), Havugimana PC (2012)	3
EMSY	3	ZNF131	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Varier RA (2016), Varier RA (2016), Varier RA (2016), Varier RA (2016), Varier RA (2016)	5
RNF2	1	SMC1A	15	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
FOXC1	0	SMARCA5	4	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	TOMM40	1	affinity chromatography technology	Li X (2015)	1
FOXC1	0	DLX5	0	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	NCOA2	2	affinity chromatography technology	Li X (2015)	1
ELAVL1	0	ZMYM2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
ZMYND8	5	GATAD2B	15	affinity chromatography technology	Hein MY (2015)	1
RNF2	1	ZMYM3	0	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	GATAD2B	15	affinity chromatography technology	Cao Q (2014)	1
FOXJ2	3	ZMYM3	0	affinity chromatography technology	Li X (2015)	1
NR3C1	2	NCOA2	2	pull down, x-ray crystallography, affinity chromatography technology, two hybrid, pull down, bioid	Zilliacus J (2001), Bledsoe RK (2002), Fryer CJ (1998), Hong H (1999), Hong H (1999), Lempiaeinen JK (2017)	6
ELAVL1	0	HDAC2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
EGLN3	0	ZNF644	6	affinity chromatography technology	Rodriguez J (2016)	1
SMARCA5	4	SMC3	16	biochemical	Hakimi MA (2002)	1
EGLN3	0	SMC3	16	affinity chromatography technology	Rodriguez J (2016)	1
GTF3C4	0	SMC1A	15	affinity chromatography technology	Boldt K (2016)	1
FOXJ2	3	DLX5	0	affinity chromatography technology	Li X (2015)	1
ELAVL1	0	LIN54	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SMARCA5	4	SMC1A	15	biochemical	Hakimi MA (2002)	1
ELAVL1	0	GTF3C1	11	affinity chromatography technology	Abdelmohsen K (2009)	1
HDAC2	1	YY1	7	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yang WM (1997), Yao YL (2001), Kalenik JL (1997), Glenn DJ (2009), Sun JM (2007)	5
ZMYM4	4	ZMYM3	0	affinity chromatography technology	Hauri S (2016)	1
ELAVL1	0	ZNF148	4	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF2	1	AKAP8	1	affinity chromatography technology	Cao Q (2014)	1
ELAVL1	0	NR3C1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
FOXJ2	3	NR3C1	2	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	ZBTB34	2	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	HOXD13	0	affinity chromatography technology	Li X (2015)	1
L3MBTL2	1	RNF2	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trojer P (2011), Trojer P (2011), Trojer P (2011), Trojer P (2011), Gao Z (2012), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
EGLN3	0	FOXC1	0	affinity chromatography technology	Rodriguez J (2016)	1
YY1	7	WDHD1	4	biochemical	Havugimana PC (2012)	1
HDAC2	1	ZMYM2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Gocke CB (2008), Bantscheff M (2011), Joshi P (2013)	4
FOXJ2	3	NACC1	9	affinity chromatography technology	Li X (2015)	1
DNTTIP1	0	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013)	3
FOXC1	0	SMARCA1	2	affinity chromatography technology	Li X (2015)	1
EGLN3	0	GTF3C4	0	affinity chromatography technology	Rodriguez J (2016)	1
POU2F2	2	NR3C1	2	pull down, pull down, pull down	Prefontaine GG (1999), Wang JM (1999), Prefontaine GG (1998)	3
FOXJ2	3	GABPA	0	affinity chromatography technology	Li X (2015)	1
EGLN3	0	WDHD1	4	affinity chromatography technology	Rodriguez J (2016)	1
MAGEA10	1	QSER1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
ZNF644	6	ADNP	37	affinity chromatography technology	Hein MY (2015)	1
HDAC2	1	ZMYM3	0	affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Bantscheff M (2011)	2
RFX1	3	RFX3	7	affinity chromatography technology	Boldt K (2016)	1
FOXJ2	3	ZNF131	0	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	WDHD1	4	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	TBP	0	affinity chromatography technology	Li X (2015)	1
EGLN3	0	NCOA2	2	affinity chromatography technology	Rodriguez J (2016)	1
FOXJ2	3	GTF3C1	11	affinity chromatography technology	Li X (2015)	1
GABPA	0	YY1	7	affinity chromatography technology	Sawa C (2002)	1
WDHD1	4	ZMYM3	0	biochemical	Havugimana PC (2012)	1
SMC1A	15	SMC3	16	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim ST (2002), Lee J (2003), Lee J (2003), Schmiesing JA (1998), Gregson HC (2001), Kueng S (2006), Schmitz J (2007), Schmitz J (2007), Losada A (2000), Kang H (2011), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Hein MY (2015), Boldt K (2016)	15
FOXJ2	3	GTSE1	3	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	SMARCA5	4	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	LIN54	1	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	SMC3	16	affinity chromatography technology	Li X (2015)	1
GATAD2B	15	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Feng Q (2002), Bantscheff M (2011), Joshi P (2013), Huttlin EL (2015), Huttlin EL (2017)	5
SMARCA1	2	SMARCA5	4	biochemical	Havugimana PC (2012)	1
EGLN3	0	GTF3C1	11	affinity chromatography technology	Rodriguez J (2016)	1
YY1	7	APP	1	pull down	Olah J (2011)	1
ZNF131	0	RNF2	1	affinity chromatography technology	Varier RA (2016)	1
FOXJ2	3	SLU7	2	affinity chromatography technology	Li X (2015)	1
FOXC1	0	SALL1	2	affinity chromatography technology	Li X (2015)	1
INTS12	0	APP	1	pull down	Olah J (2011)	1
FOXJ2	3	TSHZ1	5	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	EMSY	3	affinity chromatography technology	Li X (2015)	1
GTF3C4	0	GTF3C3	2	affinity chromatography technology, biochemical	Hsieh YJ (1999), Havugimana PC (2012)	2
FOXC1	0	HOXC13	0	affinity chromatography technology	Li X (2015)	1
L3MBTL2	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
RNF2	1	POGZ	49	affinity chromatography technology	Cao Q (2014)	1
MAGEA10	1	CUX1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC2	1	SMC3	16	biochemical	Hakimi MA (2002)	1
RNF2	1	APP	1	affinity chromatography technology	Cao Q (2014)	1
EGLN3	0	SMC1A	15	affinity chromatography technology	Rodriguez J (2016)	1
MAGEA10	1	FOXJ2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
FOXJ2	3	RFX1	3	affinity chromatography technology	Li X (2015)	1
BBX	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
L3MBTL2	1	LIN54	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
ZMYM3	0	APP	1	pull down	Olah J (2011)	1
RNF2	1	SMARCA5	4	affinity chromatography technology	Cao Q (2014)	1
FOXJ2	3	INTS12	0	affinity chromatography technology	Li X (2015)	1
NR3C1	2	POGZ	49	bioid	Lempiaeinen JK (2017)	1
FOXJ2	3	ZMYM2	5	affinity chromatography technology	Li X (2015)	1
SMARCA5	4	HDAC2	1	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, biochemical, biochemical	Hakimi MA (2002), Hakimi MA (2002), Zhou J (2005), Zhou J (2005), Zhou J (2005), Havugimana PC (2012), Wan C (2015)	7
KDM5C	9	HDAC2	1	affinity chromatography technology	Tahiliani M (2007)	1
ELAVL1	0	TBP	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	YY1	7	affinity chromatography technology	Abdelmohsen K (2009)	1
GTF3C4	0	SMC3	16	affinity chromatography technology	Boldt K (2016)	1
RNF2	1	ADNP	37	affinity chromatography technology	Cao Q (2014)	1
EGLN3	0	QRICH1	8	affinity chromatography technology	Rodriguez J (2016)	1
APP	1	QRICH1	8	two hybrid, affinity chromatography technology, affinity chromatography technology	Lakshmana MK (2005), Lakshmana MK (2005), Lakshmana MK (2005)	3
FOXJ2	3	ZMYND8	5	affinity chromatography technology	Li X (2015)	1
ZMYM4	4	CHD4	22	affinity chromatography technology	Hauri S (2016)	1
HDAC2	1	CHD4	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Hakimi MA (2003), Schmidt DR (1999), Schmidt DR (1999), Tong JK (1998), Tong JK (1998), Tong JK (1998), ONeill DW (2000), Zhang Y (1998), Zhang Y (1998), Xue Y (1998), Xue Y (1998), Xue Y (1998), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015)	17
FOXJ2	3	ZFHX4	4	affinity chromatography technology	Li X (2015)	1
NCOA2	2	UBR5	13	affinity chromatography technology	Jung SY (2005)	1
NCOA2	2	WDHD1	4	affinity chromatography technology	Jung SY (2005)	1
EMSY	3	AKAP8	1	affinity chromatography technology	Varier RA (2016)	1
ELAVL1	0	WDR55	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ZMYM4	4	ADNP	37	affinity chromatography technology	Hauri S (2016)	1
FOXJ2	3	QRICH1	8	affinity chromatography technology	Li X (2015)	1
FOXF2	1	TBP	0	pull down, pull down	Hellqvist M (1998), Hellqvist M (1998)	2
ZMYM2	5	ZMYM4	4	affinity chromatography technology, affinity chromatography technology	Gocke CB (2008), Hauri S (2016)	2
TBP	0	POU2F2	2	pull down, affinity chromatography technology	Zwilling S (1994), Zwilling S (1994)	2
FOXJ2	3	HIC2	3	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	WDR55	1	affinity chromatography technology	Li X (2015)	1
POGZ	49	APP	1	pull down	Olah J (2011)	1
FOXJ2	3	CUX1	7	affinity chromatography technology	Li X (2015)	1
FOXC1	0	HOXD13	0	affinity chromatography technology	Li X (2015)	1
ZFHX4	4	CHD4	22	affinity chromatography technology, affinity chromatography technology	Chudnovsky Y (2014), Chudnovsky Y (2014)	2
FOXJ2	3	GTF3C4	0	affinity chromatography technology	Li X (2015)	1
EYA4	1	QSER1	7	affinity chromatography technology	Boldt K (2016)	1
ZMYND8	5	CHD4	22	affinity chromatography technology	Hein MY (2015)	1
FOXJ2	3	HDAC2	1	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	ZNF536	9	affinity chromatography technology	Li X (2015)	1
RNF2	1	CHD4	22	affinity chromatography technology	Cao Q (2014)	1
FOXJ2	3	TCERG1	3	affinity chromatography technology	Li X (2015)	1
ELAVL1	0	BBX	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	CHD4	22	affinity chromatography technology	Abdelmohsen K (2009)	1
FOXJ2	3	QSER1	7	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	RBM22	0	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	RFX3	7	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	CHD4	22	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	SATB2	18	affinity chromatography technology	Li X (2015)	1
ELAVL1	0	FOXC1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
FOXJ2	3	L3MBTL2	1	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	SMARCA1	2	affinity chromatography technology	Li X (2015)	1
EGLN3	0	KLF16	1	affinity chromatography technology	Rodriguez J (2016)	1