PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DOK5	0	DOK3	5	two hybrid	Grossmann A (2015)	1
DOK5	0	RAI2	0	two hybrid	Grossmann A (2015)	1
OPRM1	0	DOK5	0	two hybrid	Petko J (2013)	1
DOK5	0	WIZ	2	two hybrid	Grossmann A (2015)	1
CCDC85B	0	DOK5	0	two hybrid	Rual JF (2005)	1
DOK5	0	RET	3	affinity chromatography technology, affinity chromatography technology, pull down	Crowder RJ (2004), Grimm J (2001), Grimm J (2001)	3
DOK5	0	CDCA4	1	two hybrid	Grossmann A (2015)	1
DOK5	0	ATF3	0	two hybrid	Grossmann A (2015)	1
DOK5	0	OLIG1	0	two hybrid	Grossmann A (2015)	1
DOK5	0	FANCG	3	two hybrid	Grossmann A (2015)	1
EGFR	5	DOK5	0	unspecified method	Jones RB (2006)	1
EGFR	5	RET	3	two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Bhinge K (2017), Bhinge K (2017)	4
DOK5	0	SCOC	3	two hybrid	Grossmann A (2015)	1
DOK5	0	TSC1	4	two hybrid	Grossmann A (2015)	1
BNIP3L	1	DOK5	0	two hybrid	Rual JF (2005)	1
DOK5	0	AHDC1	28	two hybrid	Grossmann A (2015)	1