PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HTR3C	2	RNF130	0	affinity chromatography technology	Huttlin EL (2015)	1
PON2	0	RNF130	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMEM231	1	RNF130	0	affinity chromatography technology	Huttlin EL (2015)	1
HNRNPL	3	UBE2E3	0	affinity chromatography technology	Fei T (2017)	1
ZACN	2	RNF130	0	affinity chromatography technology	Huttlin EL (2015)	1
FGFR3	7	HNRNPL	3	two hybrid	Stelzl U (2005)	1
UBE2D4	0	RNF130	0	two hybrid	van Wijk SJ (2009)	1
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
GGT7	2	RNF130	0	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
UBE2D2	0	RNF130	0	two hybrid, pull down	van Wijk SJ (2009), Guais A (2006)	2
SCGB1D4	1	RNF130	0	affinity chromatography technology	Huttlin EL (2017)	1
TSPAN17	1	RNF130	0	affinity chromatography technology	Huttlin EL (2015)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBE2D1	0	RNF130	0	two hybrid, pull down	van Wijk SJ (2009), Guais A (2006)	2
CD1B	0	RNF130	0	affinity chromatography technology	Huttlin EL (2015)	1
UBE2Z	0	RNF130	0	two hybrid	van Wijk SJ (2009)	1
MANSC1	4	RNF130	0	affinity chromatography technology	Huttlin EL (2017)	1
TMEM231	1	FGFR3	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
UBE2E1	1	RNF130	0	two hybrid, pull down	van Wijk SJ (2009), Guais A (2006)	2
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
TSPAN18	1	RNF130	0	affinity chromatography technology	Huttlin EL (2015)	1
MYC	2	RNF130	0	affinity chromatography technology	Agrawal P (2010)	1
HNRNPL	3	PON2	0	affinity chromatography technology	Fei T (2017)	1
CDC5L	2	UBE2D1	0	affinity chromatography technology	Lleres D (2010)	1
BTNL8	2	TMEM231	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2N	1	RNF130	0	two hybrid	van Wijk SJ (2009)	1
HTR3A	1	RNF130	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D3	1	RNF130	0	two hybrid, pull down	van Wijk SJ (2009), Guais A (2006)	2
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
CDC5L	2	UBE2N	1	affinity chromatography technology	Lleres D (2010)	1
HTR3C	2	TMEM231	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BTNL8	2	RNF130	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	TSPAN17	1	affinity chromatography technology	Fei T (2017)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE2E3	0	RNF130	0	two hybrid	van Wijk SJ (2009)	1
HNRNPL	3	RNF130	0	affinity chromatography technology	Fei T (2017)	1
CDC5L	2	RNF130	0	affinity chromatography technology	Lleres D (2010)	1
PTCH1	8	RNF130	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCOLN3	4	RNF130	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF130	0	UBC	7	enzymatic study	Guais A (2006)	1
NRG1	1	RNF130	0	affinity chromatography technology	Huttlin EL (2015)	1
CDC5L	2	NRG1	1	affinity chromatography technology	Lleres D (2010)	1
FGFR3	7	RNF130	0	two hybrid	Stelzl U (2005)	1