PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LATS1	3	APP	1	pull down	Olah J (2011)	1
LATS1	3	YAP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang J (2008), Zhang J (2008), Ho KC (2011), Vigneron AM (2010), Vigneron AM (2010), Huntoon CJ (2010), Hao Y (2008), Hao Y (2008), Hao Y (2008), Hao Y (2008), Matallanas D (2007), Matallanas D (2007), Oka T (2008), Oka T (2008), Oka T (2008), Yu FX (2012), Yu FX (2012), Chiyoda T (2012), Couzens AL (2013), Ho KC (2011), Salah Z (2013), Hauri S (2013), Schuchardt BJ (2014), Mei L (2017), Enzo E (2015), Si Y (2017), Guo PD (2016)	27
LATS2	1	LATS1	3	affinity chromatography technology, bioid	Xiao L (2011), Couzens AL (2013)	2
WWC3	2	WWC3	2	two hybrid	Wennmann DO (2014)	1
WWC1	5	LATS1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xiao L (2011), Xiao L (2011), Wilson KE (2014), Wilson KE (2014), Wennmann DO (2014)	5
WWC3	2	PRKCA	7	affinity chromatography technology, affinity chromatography technology	Wennmann DO (2014), Wennmann DO (2014)	2
WWC1	5	WWC3	2	two hybrid, affinity chromatography technology	Wennmann DO (2014), Wennmann DO (2014)	2
WWC2	6	LATS2	1	affinity chromatography technology	Wennmann DO (2014)	1
DLC1	11	WWC1	5	pull down, affinity chromatography technology, affinity chromatography technology	Rayala SK (2006), Rayala SK (2006), Wennmann DO (2014)	3
WWC3	2	LATS1	3	affinity chromatography technology	Wennmann DO (2014)	1
YAP1	0	WWC3	2	affinity chromatography technology	Enzo E (2015)	1
WWC3	2	LATS2	1	affinity chromatography technology	Wennmann DO (2014)	1
WWC1	5	WWC2	6	two hybrid, affinity chromatography technology	Wennmann DO (2014), Wennmann DO (2014)	2
WWC2	6	WWC3	2	two hybrid, affinity chromatography technology	Wennmann DO (2014), Wennmann DO (2014)	2
WWC2	6	LATS1	3	affinity chromatography technology	Wennmann DO (2014)	1
DLC1	11	WWC3	2	affinity chromatography technology	Wennmann DO (2014)	1
LATS2	1	YAP1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study	Ikeda M (2009), Zhang J (2008), Zhang J (2008), Vigneron AM (2010), Vigneron AM (2010), Bao Y (2009), Kawahara M (2008), Paramasivam M (2011), Aylon Y (2010), Oka T (2008), Yu FX (2012), Mo XL (2015), Rashidian J (2015), Kim M (2016), Enzo E (2015), Si Y (2017), Ivanov AA (2017), Zhu C (2018)	18
DLC1	11	WWC2	6	affinity chromatography technology	Wennmann DO (2014)	1
WWC1	5	LATS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xiao L (2011), Xiao L (2011), Wennmann DO (2014)	3
WWC3	2	APP	1	pull down	Olah J (2011)	1
WWC1	5	PRKCA	7	affinity chromatography technology, affinity chromatography technology	Wennmann DO (2014), Wennmann DO (2014)	2
WWC2	6	PRKCA	7	affinity chromatography technology, affinity chromatography technology	Wennmann DO (2014), Wennmann DO (2014)	2