PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
CDK2	0	CDC7	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Martin L (2007), Martin L (2007), Martin L (2007), Masai H (2000)	4
CDK2	0	USP7	14	affinity chromatography technology	Neganova I (2011)	1
HCFC1	4	OGT	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology	Wysocka J (2003), Wysocka J (2003), Mazars R (2010), Daou S (2011), Capotosti F (2011), Capotosti F (2011), Capotosti F (2011), Havugimana PC (2012), Hauri S (2016)	9
KMT2E	7	CDK11B	1	affinity chromatography technology	Ding X (2015)	1
CUL1	7	ILF2	3	affinity chromatography technology	Bennett EJ (2010)	1
DDX24	1	WDR12	0	biochemical	Wan C (2015)	1
ILF2	3	DHX30	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL1	7	GRWD1	3	affinity chromatography technology	Bennett EJ (2010)	1
HDAC1	4	TOP2A	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid	Tsai SC (2000), Johnson CA (2001), Johnson CA (2001), Johnson CA (2001), Johnson CA (2001)	5
HDAC1	4	KPNA3	0	affinity chromatography technology	Joshi P (2013)	1
TRIM25	5	WDR6	6	affinity chromatography technology	Choudhury NR (2017)	1
TRAF6	0	TP53	0	enzymatic study, affinity chromatography technology	Zhang X (2016), Zhang X (2016)	2
KMT2E	7	RBM39	2	affinity chromatography technology	Ding X (2015)	1
DDX50	9	KRAS	1	two hybrid	Wang J (2011)	1
TRIM25	5	OGT	4	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	DDX18	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HCFC1	4	YY1	7	affinity chromatography technology, affinity chromatography technology, pull down	Yu H (2010), Yu H (2010), Yu H (2010)	3
DDX24	1	RBBP6	7	biochemical	Wan C (2015)	1
KMT2E	7	HCFC1	4	affinity chromatography technology	Ding X (2015)	1
TP53	0	SART1	3	affinity chromatography technology	Fogeron ML (2013)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
MCM3	2	RBBP4	3	affinity chromatography technology	Mulvaney KM (2016)	1
HCFC1	4	RBBP4	3	affinity chromatography technology	Wysocka J (2003)	1
KMT2E	7	SIN3A	13	affinity chromatography technology	Ding X (2015)	1
KMT2E	7	MCM3	2	affinity chromatography technology	Ding X (2015)	1
OGT	4	USP7	14	affinity chromatography technology, affinity chromatography technology	Ding X (2015), Ding X (2015)	2
KMT2E	7	HDAC1	4	affinity chromatography technology	Ding X (2015)	1
KMT2E	7	TRAF6	0	affinity chromatography technology	Ding X (2015)	1
USP7	14	TRAF6	0	pull down, affinity chromatography technology, enzymatic study	Zapata JM (2001), Daubeuf S (2009), Bremm A (2010)	3
TP53	0	YY1	7	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Groenroos E (2004), Groenroos E (2004), Sui G (2004), Sui G (2004), Sui G (2004), Wu S (2007), Wan M (2012), Kotlyar M (2015)	8
CUL1	7	DDX18	2	affinity chromatography technology	Bennett EJ (2010)	1
KMT2E	7	ZNF768	2	affinity chromatography technology	Ding X (2015)	1
KMT2E	7	WDR12	0	affinity chromatography technology	Ding X (2015)	1
KMT2E	7	TOP2A	2	affinity chromatography technology	Ding X (2015)	1
KMT2E	7	USP10	2	affinity chromatography technology	Ding X (2015)	1
TP53	0	ASH2L	2	affinity chromatography technology, pull down	Tang Z (2013), Tang Z (2013)	2
CUL1	7	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina SA (1998), Huttlin EL (2015), Huttlin EL (2017)	4
CDK2	0	TP53	0	enzymatic study, enzymatic study, imaging technique	Luciani MG (2000), Tsai CH (2009), Chen TC (2014)	3
CDC7	2	MCM3	2	enzymatic study, pull down	Sato N (1997), Ramachandran N (2004)	2
KMT2E	7	GRWD1	3	affinity chromatography technology	Ding X (2015)	1
CDK2	0	CDK1	0	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Huttlin EL (2017)	2
TRIM25	5	YY1	7	affinity chromatography technology	Choudhury NR (2017)	1
TP53	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li M (2002), Li M (2002), Li M (2002), Li M (2002), Brooks CL (2007), Brooks CL (2007), Becker K (2007), Hu M (2006), Hu M (2006), Sarkari F (2010), Marchenko ND (2007), Epping MT (2011), Qing P (2011), Tang J (2006), Ma J (2010), Dai C (2011), Holowaty MN (2003), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Yi P (2013), Yi P (2013), Zhang J (2014), Fang Z (2013), Ye M (2015), Lim KH (2015), Lim KH (2015), Reddy BA (2014), Reddy BA (2014)	29
TRIM25	5	RBM39	2	affinity chromatography technology	Choudhury NR (2017)	1
TP53	0	RBM39	2	affinity chromatography technology	Horikawa I (2014)	1
KMT2E	7	DDX50	9	affinity chromatography technology	Ding X (2015)	1
CUL1	7	DHX30	3	affinity chromatography technology	Bennett EJ (2010)	1
KRAS	1	KMT2E	7	genetic interference	Vizeacoumar FJ (2013)	1
USP7	14	KMT2E	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ding X (2015), Ding X (2015), Ding X (2015)	3
KMT2E	7	VPS4A	4	affinity chromatography technology	Ding X (2015)	1
TP53	0	GRWD1	3	affinity chromatography technology	Fogeron ML (2013)	1
KMT2E	7	TP53	0	affinity chromatography technology	Cheng F (2011)	1
TP53	0	USP10	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Yuan J (2010), Yuan J (2010), Yuan J (2010), Yuan J (2010), Oi N (2014), Oi N (2014), Oi N (2014)	7
KMT2E	7	RBBP6	7	affinity chromatography technology	Ding X (2015)	1
MCM3	2	CDK2	0	affinity chromatography technology, pull down, pull down	Li J (2011), Li J (2011), Ramachandran N (2004)	3
HCFC1	4	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Wysocka J (2003), Wysocka J (2003)	2
TRAF6	0	KRAS	1	affinity chromatography technology	Han Q (2014)	1
KMT2E	7	CDK2	0	affinity chromatography technology	Ding X (2015)	1
ELAVL1	0	KMT2E	7	affinity chromatography technology	Abdelmohsen K (2009)	1
DDX18	2	GRWD1	3	biochemical	Wan C (2015)	1
CUL1	7	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
KMT2E	7	KPNA3	0	affinity chromatography technology	Ding X (2015)	1
HDAC1	4	YY1	7	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Yang WM (1997), He Y (2007), He G (2002), Sun JM (2007)	4
KMT2E	7	ILF2	3	affinity chromatography technology	Ding X (2015)	1
OGT	4	ASH2L	2	affinity chromatography technology	Hauri S (2016)	1
ASH2L	2	KMT2E	7	pull down	Li Y (2016)	1
ILF2	3	DDX18	2	affinity chromatography technology	Huttlin EL (2015)	1
TRIM25	5	VPS4A	4	affinity chromatography technology	Choudhury NR (2017)	1
CDK2	0	ILF2	3	affinity chromatography technology	Neganova I (2011)	1
KMT2E	7	DDX24	1	affinity chromatography technology	Ding X (2015)	1
CDK2	0	OGT	4	affinity chromatography technology	Ewing RM (2007)	1
CDK2	0	HCFC1	4	affinity chromatography technology	Neganova I (2011)	1
TRIM25	5	SART1	3	affinity chromatography technology	Choudhury NR (2017)	1
SIN3A	13	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Murphy M (1999), Murphy M (1999), Murphy M (1999), Zilfou JT (2001)	4
TRIM25	5	CDK1	0	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	RBBP4	3	affinity chromatography technology	Abdelmohsen K (2009)	1
SIN3A	13	OGT	4	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Yang X (2002), Yang X (2002), Yang X (2002), Whisenhunt TR (2006)	4
TRIM25	5	DDX24	1	affinity chromatography technology	Choudhury NR (2017)	1
CUL1	7	RBM39	2	affinity chromatography technology	Bennett EJ (2010)	1
KMT2E	7	SMYD3	0	affinity chromatography technology	Ding X (2015)	1
TRIM25	5	USP7	14	affinity chromatography technology	Choudhury NR (2017)	1
CDK1	0	KMT2E	7	enzymatic study	Liu J (2010)	1
ELAVL1	0	KRAS	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	HCFC1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
RBBP6	7	TP53	0	affinity chromatography technology, pull down	Simons A (1997), Simons A (1997)	2
KMT2E	7	RBBP4	3	affinity chromatography technology	Ding X (2015)	1
KMT2E	7	WDR6	6	affinity chromatography technology	Ding X (2015)	1
TP53	0	TOP2A	2	affinity chromatography technology, pull down, genetic interference	Cowell IG (2000), Cowell IG (2000), Xie L (2013)	3
ILF2	3	MCM3	2	affinity chromatography technology	Karmakar S (2010)	1
KMT2E	7	DHX30	3	affinity chromatography technology	Ding X (2015)	1
KMT2E	7	TRIM25	5	affinity chromatography technology	Ding X (2015)	1
ASH2L	2	HCFC1	4	pull down, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Mak AB (2010), Tang Z (2013)	3
CDK1	0	TP53	0	enzymatic study, affinity chromatography technology	Luciani MG (2000), Ababneh M (2001)	2
CUL1	7	RBBP6	7	affinity chromatography technology	Bennett EJ (2010)	1
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
TP53	0	RBBP4	3	affinity chromatography technology	Fogeron ML (2013)	1
TRIM25	5	SIN3A	13	affinity chromatography technology	Choudhury NR (2017)	1
SIN3A	13	RBBP4	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hassig CA (1997), Zhang Y (1998), Nakamura T (2002), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Bantscheff M (2011), Hauri S (2016)	8
ELAVL1	0	YY1	7	affinity chromatography technology	Abdelmohsen K (2009)	1
KMT2E	7	YY1	7	affinity chromatography technology	Ding X (2015)	1
DDX24	1	GRWD1	3	biochemical	Wan C (2015)	1
KMT2E	7	OGT	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ding X (2015), Ding X (2015), Ding X (2015)	3
DDX18	2	DDX24	1	biochemical	Wan C (2015)	1
KMT2E	7	DDX18	2	affinity chromatography technology	Ding X (2015)	1
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
HCFC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Yokoyama A (2004), Wysocka J (2003), Wysocka J (2003), Wysocka J (2003), Mangone M (2010)	5
TRAF6	0	USP10	2	affinity chromatography technology	Wang W (2015)	1
RBBP4	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Nicolas E (2001), Nicolas E (2001), Grozinger CM (1999), You A (2001), Hassig CA (1997), Hassig CA (1997), Ng HH (1999), Zhang Y (1999), Zhang Y (2002), Hassig CA (1998), Zhang Y (1997), Banach-Orlowska M (2009), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	35
CUL1	7	KMT2E	7	affinity chromatography technology	Bennett EJ (2010)	1
KMT2E	7	SART1	3	affinity chromatography technology	Ding X (2015)	1
KPNA3	0	RBBP4	3	pull down	Tsujii A (2015)	1
TRIM25	5	RBBP4	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	ILF2	3	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TP53	0	DDX50	9	genetic interference	Xie L (2013)	1
KMT2E	7	CDC7	2	affinity chromatography technology	Ding X (2015)	1