PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF2	1	RNF114	0	affinity chromatography technology	Cao Q (2014)	1
LTBR	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
SMURF1	4	UBE2D2	0	pull down, pull down	Kristariyanto YA (2015), Andrews PS (2010)	2
RNF2	1	UBE2D2	0	enzymatic study, two hybrid, pull down	Lee SJ (2001), Markson G (2009), Dou H (2012)	3
SMURF1	4	UBE2D1	0	pull down, enzymatic study	Kristariyanto YA (2015), Andrews PS (2010)	2
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
BMI1	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
MAP3K1	4	UBE2K	0	enzymatic study	Charlaftis N (2014)	1
UBE2D4	0	TRAF6	0	two hybrid	Markson G (2009)	1
UBE2K	0	RNF2	1	two hybrid, pull down, affinity chromatography technology, two hybrid	Lee SJ (2001), Lee SJ (2001), Lee SJ (2001), Markson G (2009)	4
LTBR	0	TRAF4	1	pull down	Krajewska M (1998)	1
MAVS	1	RNF114	0	affinity chromatography technology, imaging technique, biochemical	Lin B (2017), Lin B (2017), Lin B (2017)	3
LAGE3	0	RNF114	0	biochemical	Havugimana PC (2012)	1
PARP11	0	RNF114	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
RNF114	0	RNF114	0	enzymatic study, enzymatic study	Han J (2013), Bijlmakers MJ (2011)	2
UBE2U	0	RNF114	0	two hybrid	van Wijk SJ (2009)	1
UBE2E1	1	RNF166	0	two hybrid	Markson G (2009)	1
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
TRAIP	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
UBE2D3	1	RNF166	0	two hybrid	Markson G (2009)	1
SUZ12	0	RNF114	0	affinity chromatography technology	Cao Q (2014)	1
RNF166	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chen HW (2015), Chen HW (2015)	2
UBE2D4	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
RNF2	1	EWSR1	2	affinity chromatography technology	Cao Q (2014)	1
RNF166	0	MAVS	1	affinity chromatography technology	Chen HW (2015)	1
MAP3K1	4	RNF114	0	enzymatic study	Charlaftis N (2014)	1
UBE2D2	0	RNF166	0	two hybrid	Markson G (2009)	1
UEVLD	3	TRAF6	0	two hybrid	Markson G (2009)	1
TRAIP	0	UBE2D2	0	pull down	Besse A (2007)	1
UBE2D1	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
RNF38	4	DTX3	4	two hybrid	Woodsmith J (2012)	1
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
UBE2E3	0	RNF114	0	two hybrid	Markson G (2009)	1
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
UBE2W	0	DTX3	4	two hybrid	Markson G (2009)	1
100131816	0	DTX3	4	two hybrid	Markson G (2009)	1
PLP1	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D3	1	RNF114	0	two hybrid, enzymatic study	Markson G (2009), Lin B (2017)	2
UBE2K	0	TRAIP	0	two hybrid	Markson G (2009)	1
SMURF1	4	RNF114	0	enzymatic study	Andrews PS (2010)	1
EWSR1	2	SUZ12	0	two hybrid, affinity chromatography technology	Ravasi T (2010), Cao Q (2014)	2
UBE2D4	0	DTX3	4	two hybrid	Markson G (2009)	1
SMURF1	4	UBE2K	0	enzymatic study	Andrews PS (2010)	1
UBE2H	3	RNF114	0	two hybrid	Markson G (2009)	1
UBE2W	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
BMI1	0	TRAF4	1	affinity chromatography technology	Cao Q (2014)	1
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
PARP12	1	RNF166	0	affinity chromatography technology	Huttlin EL (2017)	1
DTX3	4	RNF114	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2E3	0	DTX3	4	two hybrid	Markson G (2009)	1
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
CD93	1	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
HSPB1	2	RPSA	2	two hybrid	Katsogiannou M (2014)	1
UBE2W	0	RNF2	1	two hybrid	Markson G (2009)	1
EVI2A	1	RNF114	0	two hybrid	Wang J (2011)	1
DSTN	0	RNF114	0	biochemical	Havugimana PC (2012)	1
CDKN1A	1	UBE2D1	0	two hybrid	Vinayagam A (2011)	1
BMI1	0	RNF2	1	biochemical, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Cao R (2005), Ben-Saadon R (2006), Li Z (2006), Maertens GN (2009), Wei J (2006), Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Pan MR (2011), Pan MR (2011), Voncken JW (2005), Woodsmith J (2012), Voncken JW (2003), Woodsmith J (2012), Li Z (2006), Li Z (2006), McGinty RK (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Balasubramanian S (2015), Taherbhoy AM (2015), Taherbhoy AM (2015), Abdouh M (2016), Sanchez A (2016), Wheaton K (2017), Hauri S (2016), Hauri S (2016)	30
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBE2E1	1	RNF114	0	two hybrid, enzymatic study	Markson G (2009), Lin B (2017)	2
UBE2D1	0	DTX3	4	two hybrid	Markson G (2009)	1
HSP90AA1	7	RPSA	2	affinity chromatography technology	Falsone SF (2005)	1
TNFAIP3	3	RNF114	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rodriguez MS (2014), Rodriguez MS (2014), Rodriguez MS (2014), Rodriguez MS (2014), Huttlin EL (2017)	5
UBE2E1	1	RNF2	1	two hybrid, affinity chromatography technology, pull down	Markson G (2009), Wheaton K (2017), Wheaton K (2017)	3
UBE2D3	1	DTX3	4	two hybrid	Markson G (2009)	1
UBE2E2	1	RNF2	1	two hybrid	Markson G (2009)	1
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
PARP11	0	RNF166	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BMI1	0	EWSR1	2	affinity chromatography technology	Cao Q (2014)	1
UBE2E2	1	RNF114	0	two hybrid	Markson G (2009)	1
XAF1	1	RNF114	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down	Han J (2013), Han J (2013), Han J (2013), Han J (2013), Lee MG (2014), Lee MG (2014)	6
TRAF4	1	DTX3	4	two hybrid	Woodsmith J (2012)	1
UEVLD	3	RNF114	0	two hybrid	Markson G (2009)	1
RNF114	0	USO1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D1	0	TRIM55	2	two hybrid	Markson G (2009)	1
NUDCD2	2	RNF114	0	biochemical	Havugimana PC (2012)	1
PARP12	1	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
CPLX1	0	RNF114	0	biochemical	Havugimana PC (2012)	1
UBE2D4	0	RNF38	4	two hybrid	Markson G (2009)	1
UBE2H	3	TRAIP	0	two hybrid	Markson G (2009)	1
RNF114	0	IDI2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D2	0	TRIM55	2	two hybrid	Markson G (2009)	1
UBE2D1	0	RNF114	0	two hybrid, pull down, enzymatic study	Markson G (2009), Bijlmakers MJ (2011), Lin B (2017)	3
HSP90AA1	7	TNFAIP3	3	affinity chromatography technology	Taipale M (2012)	1
HSPB1	2	HSP90AA1	7	two hybrid	Katsogiannou M (2014)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
UBE2E2	1	RNF166	0	two hybrid	Markson G (2009)	1
UBE2D3	1	TRIM55	2	two hybrid, pull down	Markson G (2009), Loch CM (2012)	2
RNF114	0	TRIM52	0	two hybrid	Woodsmith J (2012)	1
AUP1	0	RNF114	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	UEVLD	3	pull down	Nathan JA (2013)	1
UBE2E1	1	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
RNF114	0	AK5	2	two hybrid	Stelzl U (2005)	1
UBE2K	0	DTX3	4	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
EWSR1	2	RPSA	2	bioid	Elzi DJ (2014)	1
UBE2D2	0	DTX3	4	two hybrid	Markson G (2009)	1
MAPK3	4	RNF114	0	two hybrid	Vinayagam A (2011)	1
UBE2W	0	RNF114	0	two hybrid	Markson G (2009)	1
UBE2E3	0	RNF166	0	two hybrid	Markson G (2009)	1
RNF114	0	RNF38	4	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	RNF114	0	two hybrid	Markson G (2009)	1
MAP3K1	4	MAPK3	4	enzymatic study, imaging technique	Loke J (2014), Chen TC (2014)	2
LTBR	0	RNF166	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSPB1	2	RNF114	0	biochemical	Havugimana PC (2012)	1
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
RNF2	1	UBE2D1	0	enzymatic study, two hybrid	Lee SJ (2001), Markson G (2009)	2
TRAIP	0	UBE2D1	0	pull down	Besse A (2007)	1
TRAF6	0	UBE2E1	1	pull down	Markson G (2009)	1
UBC	7	RNF38	4	pull down, enzymatic study	Buetow L (2015), Buetow L (2015)	2
UBE2D3	1	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
UBC	7	HSPB1	2	affinity chromatography technology	Matsumoto M (2005)	1
UBE2E1	1	DTX3	4	two hybrid	Markson G (2009)	1
RNF166	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
SUZ12	0	RNF2	1	affinity chromatography technology	Cao Q (2014)	1
TRAIP	0	TRAF6	0	affinity chromatography technology	Besse A (2007)	1
EWSR1	2	RNF114	0	bioid	Elzi DJ (2014)	1
UBE2D3	1	RNF2	1	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Markson G (2009), Bentley ML (2011), Li Z (2006), Pan MR (2011), Zhang Y (2014), Xia P (2014), Gearhart MD (2006), McGinty RK (2014), Cao Q (2014), Gao Z (2014)	10
UBE2D4	0	RNF2	1	two hybrid	Markson G (2009)	1
UBC	7	RNF114	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Capon F (2008), Fenner BJ (2009), Fenner BJ (2009)	4
TRAF6	0	TRAF4	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Takeshita F (2005), Takeshita F (2005), Chen TC (2014)	3
UBE2D2	0	RNF38	4	two hybrid, pull down, pull down	Markson G (2009), Sheren JE (2013), Buetow L (2015)	3
TRAF4	1	RNF114	0	two hybrid	Woodsmith J (2012)	1
UBE2U	0	TRAIP	0	two hybrid	van Wijk SJ (2009)	1
100131816	0	RNF114	0	two hybrid	Markson G (2009)	1
RNF2	1	UBC	7	enzymatic study	Woodsmith J (2012)	1
SUZ12	0	TRAF4	1	affinity chromatography technology	Cao Q (2014)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
RNF114	0	RPSA	2	two hybrid	Wang J (2011)	1
TRAIP	0	UBE2D3	1	pull down	Besse A (2007)	1
TRAF6	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
UBE2E3	0	RNF2	1	two hybrid	Markson G (2009)	1
NUDCD2	2	HSP90AA1	7	affinity chromatography technology	Yang Y (2010)	1
UBE2D2	0	RNF114	0	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Markson G (2009), Huttlin EL (2015), Huttlin EL (2017), Lin B (2017)	4
UBE2H	3	RNF2	1	two hybrid	Markson G (2009)	1
MAPK3	4	USO1	1	affinity chromatography technology	How PC (2011)	1
TNFAIP3	3	RNF166	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D1	0	RNF38	4	two hybrid	Markson G (2009)	1
SMURF1	4	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Nie J (2010), Nie J (2010), Fei C (2013), Wang J (2013), Cao Y (2014), Xie P (2014), Xie P (2014), Lu K (2008), Kristariyanto YA (2015), Andrews PS (2010), He S (2017), Zhang Y (2017)	12
UBE2D4	0	RNF166	0	two hybrid	Markson G (2009)	1
RPSA	2	LAGE3	0	biochemical	Wan C (2015)	1
CDKN1A	1	RNF114	0	genetic interference	Han J (2013)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
UBC	7	APC	5	affinity chromatography technology	Matsumoto M (2005)	1
UEVLD	3	DTX3	4	two hybrid	Markson G (2009)	1
LACRT	1	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
RNF2	1	PARP12	1	affinity chromatography technology	Cao Q (2014)	1
UBE2H	3	DTX3	4	two hybrid	Markson G (2009)	1
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
APC	5	RNF114	0	affinity chromatography technology	Novellasdemunt L (2017)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE2E2	1	DTX3	4	two hybrid	Markson G (2009)	1
UBE2D2	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
UBE2D3	1	RNF38	4	two hybrid	Markson G (2009)	1
RNF2	1	RPSA	2	affinity chromatography technology	Cao Q (2014)	1
UBE2D1	0	RNF166	0	two hybrid	Markson G (2009)	1
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
RNF114	0	TRIM55	2	two hybrid	Woodsmith J (2012)	1
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
HSP90AA1	7	CDKN1A	1	affinity chromatography technology	Jascur T (2005)	1
BMI1	0	UBE2D3	1	pull down, pull down, pull down, pull down	Bentley ML (2011), Li Z (2006), Zhang Y (2014), Taherbhoy AM (2015)	4
SMURF1	4	TRAF4	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, genetic interference, enzymatic study	Li S (2010), Li S (2010), Li S (2010), Li S (2010), Li S (2010), Zhang L (2013)	6
UBE2U	0	RNF2	1	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	RNF166	0	two hybrid	van Wijk SJ (2009)	1
UBE2H	3	RNF166	0	two hybrid	Markson G (2009)	1
UBE2H	3	RNF38	4	two hybrid	Markson G (2009)	1
UBE2K	0	RNF114	0	two hybrid	Markson G (2009)	1
SMURF1	4	MAVS	1	affinity chromatography technology	Wang Y (2012)	1
RNF114	0	HSP90AA1	7	biochemical	Bijlmakers MJ (2011)	1
AUP1	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011)	2
UBE2W	0	RNF166	0	two hybrid	Markson G (2009)	1