PPI network (data source: BioGrid)

Symbol A GeneA coding DNM count Symbol B GeneB coding DNM count Interaction detection method Publication Evidence
ERBB2 6 CLTC 12 affinity chromatography technology Giri DK (2005) 1
ERBIN 5 ATP2B4 5 unspecified method Boisguerin P (2004) 1
MYO19 0 PPP1CC 2 affinity chromatography technology Hein MY (2015) 1
ZFYVE9 5 PPP1CC 2 two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Colland F (2004), Rolland T (2014), Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017) 5
CFTR 5 ACTN2 2 affinity chromatography technology Pankow S (2015) 1
ERBIN 5 CASK 18 unspecified method Boisguerin P (2004) 1
HNRNPL 3 ATP2B1 6 affinity chromatography technology Fei T (2017) 1
CFTR 5 CLTC 12 affinity chromatography technology Pankow S (2015) 1
APC 5 XPO1 8 affinity chromatography technology, pull down Tickenbrock L (2002), Tickenbrock L (2002) 2
LMO2 2 STAT3 0 two hybrid Rolland T (2014) 1
ITGB4 11 ERBIN 5 two hybrid, pull down Favre B (2001), Favre B (2001) 2
MYC 2 XPO1 8 affinity chromatography technology, affinity chromatography technology Koch HB (2007), Kirli K (2015) 2
SMAD7 1 CTNNB1 30 affinity chromatography technology, imaging technique, affinity chromatography technology Edlund S (2005), Edlund S (2005), Tang Y (2008) 3
HNRNPL 3 MEF2A 1 affinity chromatography technology Fei T (2017) 1
CFTR 5 COPB1 0 affinity chromatography technology, affinity chromatography technology Wang X (2006), Pankow S (2015) 2
PPP1CA 3 CLTC 12 two hybrid Esteves SL (2012) 1
SMAD7 1 ERBIN 5 pull down Warner DR (2003) 1
ZNF764 2 TRIM41 6 affinity chromatography technology Huttlin EL (2017) 1
TMEM17 0 MPP1 1 bioid Gupta GD (2015) 1
ZFYVE9 5 ERBIN 5 two hybrid Colland F (2004) 1
CHUK 5 FOXO3 1 affinity chromatography technology, pull down Hu MC (2004), Hu MC (2004) 2
ERBIN 5 ARHGEF7 3 unspecified method Boisguerin P (2004) 1
ERBIN 5 CBL 7 affinity chromatography technology Yao S (2015) 1
ZNF563 1 ERBIN 5 affinity chromatography technology Huttlin EL (2017) 1
CFTR 5 ATP2B4 5 affinity chromatography technology Pankow S (2015) 1
ERBIN 5 PICK1 2 two hybrid Jaulin-Bastard F (2001) 1
PPP1CA 3 ERBIN 5 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017) 5
APC 5 ERBIN 5 two hybrid, unspecified method Bandyopadhyay S (2010), Boisguerin P (2004) 2
XPO1 8 CTNND1 4 affinity chromatography technology Kirli K (2015) 1
GTSE1 3 ERBIN 5 affinity chromatography technology Hein MY (2015) 1
ZNF550 3 ERBIN 5 affinity chromatography technology Huttlin EL (2017) 1
ARHGAP19 4 ERBIN 5 affinity chromatography technology Huttlin EL (2017) 1
CFTR 5 DBN1 1 affinity chromatography technology Pankow S (2015) 1
ERBIN 5 FOXO3 1 unspecified method Boisguerin P (2004) 1
ACVR2B 0 SMAD2 5 affinity chromatography technology Miura S (2000) 1
SMAD1 0 FOXO3 1 affinity chromatography technology Sapkota G (2007) 1
CFTR 5 XPO1 8 affinity chromatography technology, affinity chromatography technology Wang X (2006), Pankow S (2015) 2
APC 5 CTNNB1 30 affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Su LK (1993), Su LK (1993), Kucerova D (2001), Tickenbrock L (2003), Davies G (2001), Ryo A (2001), Homma MK (2002), Tickenbrock L (2003), Davies G (2001), Satoh K (1997), Eklof Spink K (2001), Eklof Spink K (2001), Sierra J (2006), Choi J (2004), Huang X (2009), Brocardo MG (2011), Xing Y (2004), Xing Y (2004), Xing Y (2004), Hamada F (2004), Hamada F (2004), Schneikert J (2013), Hsi LC (1999), Hein MY (2015), Hein MY (2015), Chen TC (2014), Kuslansky Y (2016), Novellasdemunt L (2017), Novellasdemunt L (2017) 29
HNRNPL 3 FOXO3 1 affinity chromatography technology Fei T (2017) 1
CFTR 5 CBL 7 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Ye S (2010), Ye S (2010), Bomberger JM (2012), Arora K (2016) 4
ERBB2 6 STAT3 0 affinity chromatography technology, unspecified method Ren Z (2002), Jones RB (2006) 2
ERBIN 5 ATP2B2 10 unspecified method Boisguerin P (2004) 1
DST 13 ERBIN 5 two hybrid, pull down Favre B (2001), Favre B (2001) 2
RPAP1 5 ERBIN 5 affinity chromatography technology Jeronimo C (2007) 1
SMAD3 1 BTRC 1 affinity chromatography technology Wan M (2004) 1
DBN1 1 ACTN1 5 affinity chromatography technology Hein MY (2015) 1
ZNF785 0 TRIM41 6 affinity chromatography technology Huttlin EL (2017) 1
AZU1 0 ERBIN 5 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
ERBIN 5 LMO1 0 unspecified method Boisguerin P (2004) 1
CFTR 5 BCR 3 affinity chromatography technology Wang X (2006) 1
SMAD4 9 SMAD2 5 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017) 56
CLTC 12 ERBIN 5 affinity chromatography technology Hein MY (2015) 1
ERBIN 5 LAMB1 10 unspecified method Boisguerin P (2004) 1
RIPK4 0 RBX1 2 affinity chromatography technology Rodriguez J (2016) 1
ERBIN 5 LRRC1 1 pull down Saito H (2001) 1
SMAD2 5 ZFYVE9 5 affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology Lin HK (2004), Tsukazaki T (1998), Tsukazaki T (1998), Faresse N (2008), Miura S (2000), Seo SR (2006), Brown KA (2008), Colland F (2004), Lu D (2013) 9
APC 5 DST 13 two hybrid Bandyopadhyay S (2010) 1
MED4 2 DST 13 bioid Lambert JP (2015) 1
ERBIN 5 ERBIN 5 two hybrid, pull down Jaulin-Bastard F (2001), Jaulin-Bastard F (2001) 2
STAT3 0 SMAD1 0 affinity chromatography technology Nakashima K (1999) 1
ERBIN 5 ABR 5 unspecified method Boisguerin P (2004) 1
ERBIN 5 MEF2A 1 unspecified method Boisguerin P (2004) 1
EGLN3 0 PPP1CA 3 affinity chromatography technology Rodriguez J (2016) 1
ERBIN 5 NR2E1 0 unspecified method Boisguerin P (2004) 1
CFTR 5 CDH1 4 affinity chromatography technology, affinity chromatography technology Wang X (2006), Pankow S (2015) 2
ERBB2 6 PICK1 2 two hybrid, affinity chromatography technology Jaulin-Bastard F (2001), Jaulin-Bastard F (2001) 2
CDH1 4 ATP2B1 6 bioid Guo Z (2014) 1
TMEM17 0 DST 13 bioid Gupta GD (2015) 1
APC 5 ACTN1 5 two hybrid Bandyopadhyay S (2010) 1
ARHGEF7 3 CBL 7 two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Flanders JA (2003), Flanders JA (2003), Schmidt MH (2006), Schmidt MH (2006), Schmidt MH (2006), Wu WJ (2003), Singh VK (2012), Singh VK (2012), Chang CC (2012) 9
TMEM17 0 SLC5A6 3 bioid Gupta GD (2015) 1
CHUK 5 PPP1CA 3 affinity chromatography technology, affinity chromatography technology Mitsuhashi S (2008), Mitsuhashi S (2008) 2
STAT3 0 CBL 7 two hybrid Grossmann A (2015) 1
MYC 2 PDZD2 5 affinity chromatography technology Agrawal P (2010) 1
EGLN3 0 GTSE1 3 affinity chromatography technology Rodriguez J (2016) 1
ERBIN 5 LMO2 2 two hybrid Wang J (2011) 1
ERBIN 5 CTNND1 4 pull down Laura RP (2002) 1
HRAS 2 CBL 7 affinity chromatography technology Lito P (2008) 1
EGLN3 0 CTNND1 4 affinity chromatography technology Rodriguez J (2016) 1
SMAD7 1 CDH1 4 affinity chromatography technology Tang Y (2008) 1
TMEM17 0 PKP4 5 bioid Gupta GD (2015) 1
HNRNPL 3 ABR 5 affinity chromatography technology Fei T (2017) 1
XPO1 8 BCR 3 affinity chromatography technology Kirli K (2015) 1
PPP1CC 2 ERBIN 5 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017) 5
CDH1 4 ATP2B4 5 bioid Guo Z (2014) 1
RIPK4 0 COPB1 0 affinity chromatography technology Rodriguez J (2016) 1
SMAD1 0 SMAD7 1 affinity chromatography technology Yan X (2016) 1
SMAD2 5 SMAD7 1 genetic interference, pull down, affinity chromatography technology Lebrun JJ (1999), Zhang S (2007), Yan X (2016) 3
HNRNPL 3 ACVR2B 0 affinity chromatography technology Fei T (2017) 1
EGLN3 0 CHUK 5 affinity chromatography technology Fu J (2013) 1
MYO19 0 GTSE1 3 affinity chromatography technology Hein MY (2015) 1
BTRC 1 CHUK 5 enzymatic study Liu J (2002) 1
SMAD7 1 SMAD3 1 genetic interference, genetic interference, affinity chromatography technology, protein complementation assay Datta PK (2000), Lebrun JJ (1999), Yan X (2016), Yan X (2016) 4
ERBB2 6 CTNNB1 30 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, far western blotting Schroeder JA (2002), Bonvini P (2001), Schroeder JA (2002), Schroeder JA (2002), Kanai Y (1995), Kanai Y (1995) 6
MYC 2 PPP1CA 3 affinity chromatography technology Koch HB (2007) 1
CTNNB1 30 CTNND1 4 affinity chromatography technology, affinity chromatography technology Hazan RB (1998), Kucerova D (2001) 2
DBN1 1 ERBIN 5 affinity chromatography technology Hein MY (2015) 1
RNF7 0 ERBIN 5 enzymatic study Kuang P (2016) 1
TMEM17 0 ERBIN 5 bioid Gupta GD (2015) 1
GTSE1 3 CLTC 12 affinity chromatography technology, affinity chromatography technology Hein MY (2015), Hein MY (2015) 2
GTSE1 3 PKP4 5 affinity chromatography technology Hein MY (2015) 1
ERBIN 5 SLC6A12 4 unspecified method Boisguerin P (2004) 1
XPO1 8 COPB1 0 affinity chromatography technology Kirli K (2015) 1
ERBIN 5 BCR 3 unspecified method, affinity chromatography technology, affinity chromatography technology Boisguerin P (2004), Boisguerin P (2004), Boisguerin P (2004) 3
PPP1R3A 2 ERBIN 5 affinity chromatography technology Hauri S (2013) 1
EGLN3 0 ERBIN 5 affinity chromatography technology Rodriguez J (2016) 1
ERBIN 5 GRIN2C 4 pull down, unspecified method Jaulin-Bastard F (2001), Boisguerin P (2004) 2
MYO19 0 DBN1 1 affinity chromatography technology, affinity chromatography technology Hein MY (2015), Hein MY (2015) 2
DBN1 1 DST 13 affinity chromatography technology Hein MY (2015) 1
TMEM17 0 ATP2B1 6 bioid Gupta GD (2015) 1
HNRNPL 3 HOXC4 1 affinity chromatography technology Fei T (2017) 1
HRAS 2 BTRC 1 pull down, affinity chromatography technology, affinity chromatography technology Kim SE (2009), Kim SE (2009), Kim SE (2009) 3
XPO1 8 CHUK 5 affinity chromatography technology Kirli K (2015) 1
ERBIN 5 ABCC4 3 unspecified method Boisguerin P (2004) 1
EGLN3 0 ZFYVE9 5 affinity chromatography technology Rodriguez J (2016) 1
SMAD4 9 SMAD7 1 genetic interference, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology Lebrun JJ (1999), Moren A (2005), Moren A (2005), Moren A (2005), Zhang S (2007), Yan X (2016) 6
ZNF408 0 ERBIN 5 affinity chromatography technology Huttlin EL (2017) 1
XPO1 8 SMAD1 0 affinity chromatography technology Kirli K (2015) 1
RNF7 0 CUL3 17 enzymatic study Huang DT (2009) 1
EGLN3 0 XPO1 8 affinity chromatography technology Rodriguez J (2016) 1
ERBIN 5 GRIN2B 30 pull down Jaulin-Bastard F (2001) 1
XPO1 8 CTNNB1 30 affinity chromatography technology Kirli K (2015) 1
EGLN3 0 LRRC1 1 affinity chromatography technology Rodriguez J (2016) 1
ERBIN 5 ACTN2 2 unspecified method Boisguerin P (2004) 1
CTSK 0 ERBIN 5 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
ATP2B2 10 ATP2B4 5 affinity chromatography technology Huttlin EL (2017) 1
BTRC 1 APC 5 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology Sowa ME (2009), Kitagawa M (1999), Hart M (1999), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Novellasdemunt L (2017) 7
MYC 2 ERBB2 6 fluorescent resonance energy transfe Ivanov AA (2017) 1
TMEM17 0 CTNND1 4 bioid Gupta GD (2015) 1
RBX1 2 CUL3 17 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014) 18
MCC 3 CLTC 12 affinity chromatography technology Ewing RM (2007) 1
PPP1R3A 2 ZFYVE9 5 affinity chromatography technology Hauri S (2013) 1
SMAD3 1 CTNNB1 30 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Tian YC (2002), Dahle O (2010), Charbonney E (2011), Zhou B (2012) 4
ZNF785 0 ERBIN 5 affinity chromatography technology Huttlin EL (2017) 1
MYC 2 ERBIN 5 affinity chromatography technology Agrawal P (2010) 1
ERBIN 5 KCNA5 2 unspecified method Boisguerin P (2004) 1
SMAD7 1 CBL 7 affinity chromatography technology, affinity chromatography technology, pull down Ha Thi HT (2015), Ha Thi HT (2015), Ha Thi HT (2015) 3
CUL3 17 CLTC 12 affinity chromatography technology Bennett EJ (2010) 1
ERBIN 5 CTNNB1 30 unspecified method Boisguerin P (2004) 1
SMAD1 0 SMAD4 9 affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017) 14
EGLN3 0 MCC 3 affinity chromatography technology Rodriguez J (2016) 1
TRIM41 6 ERBIN 5 affinity chromatography technology Huttlin EL (2017) 1
ZNF264 2 ERBIN 5 affinity chromatography technology Huttlin EL (2017) 1
MYC 2 SMAD2 5 affinity chromatography technology, pull down, two hybrid, fluorescent resonance energy transfe Feng XH (2002), Feng XH (2002), Feng XH (2002), Ivanov AA (2017) 4
CDH1 4 ERBIN 5 bioid Guo Z (2014) 1
MYC 2 FOXO3 1 affinity chromatography technology Chandramohan V (2008) 1
ZNF517 0 ERBIN 5 affinity chromatography technology Huttlin EL (2017) 1
XRCC3 1 ERBIN 5 affinity chromatography technology Hein MY (2015) 1
TRMT2A 4 ERBIN 5 affinity chromatography technology Huttlin EL (2017) 1
SMAD3 1 SMAD1 0 affinity chromatography technology, two hybrid, two hybrid Brown KA (2008), Wu RY (1997), Wu RY (1997) 3
ACTN2 2 GRIN2B 30 two hybrid, biochemical Wyszynski M (1997), Wyszynski M (1997) 2
ERBIN 5 ARVCF 5 pull down, unspecified method Laura RP (2002), Boisguerin P (2004) 2
OBP2A 0 ERBIN 5 affinity chromatography technology Huttlin EL (2017) 1
HNRNPL 3 PDZD2 5 affinity chromatography technology Fei T (2017) 1
MYO19 0 CLTC 12 affinity chromatography technology Hein MY (2015) 1
DST 13 ITGB4 11 two hybrid Hopkinson SB (2000) 1
ERBIN 5 SLC5A6 3 unspecified method Boisguerin P (2004) 1
ERBIN 5 ACVR2B 0 unspecified method Boisguerin P (2004) 1
CDH1 4 CTNNB1 30 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid Davies G (2001), Kucerova D (2001), Oyama T (1994), Hazan RB (1997), Kinch MS (1995), Jiang MC (2002), Hazan RB (1998), Bonvini P (2001), Li Y (1998), Wendeler MW (2004), Shibata T (2003), Piedra J (2003), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Geng L (2000), Shibamoto S (1995), Rao RK (2002), Rao RK (2002), Huber AH (2001), Schmeiser K (1999), Pai R (2008), Tu LC (2007), Tu LC (2007), Smyth D (2012), Xue B (2005), Xue B (2005), Catimel B (2005), Huang Z (2012), Yan HX (2006), Yan HX (2006), Figueiredo J (2013), Ponce E (2014), Ponce E (2014), Ponce E (2014), Ribeiro AS (2013), Pinheiro H (2012), Geng F (2012), Lee HK (2007), Guo Z (2014) 42
CBL 7 ERBB2 6 pull down, affinity chromatography technology Zhou P (2003), Bisaro B (2016) 2
ERBIN 5 ACTN1 5 unspecified method Boisguerin P (2004) 1
ATP2B2 10 ABCC4 3 affinity chromatography technology Huttlin EL (2017) 1
PPP1CC 2 LRRC1 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017) 3
PPP1CA 3 CDH1 4 affinity chromatography technology, bioid Flores-Delgado G (2007), Guo Z (2014) 2
HNRNPL 3 ABCC4 3 affinity chromatography technology Fei T (2017) 1
CFTR 5 ITGB4 11 affinity chromatography technology Pankow S (2015) 1
CUL3 17 CTNNB1 30 affinity chromatography technology Bennett EJ (2010) 1
ATP2B4 5 CASK 18 pull down, biochemical Schuh K (2003), Schuh K (2003) 2
BTRC 1 SMAD4 9 two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Wan M (2004), Wan M (2004), Yang L (2006), Yang L (2006), Wan M (2005), Liang M (2004), Demagny H (2014), Li D (2015) 8
PKP4 5 ERBIN 5 two hybrid, pull down, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down Izawa I (2002), Izawa I (2002), Izawa I (2002), Jaulin-Bastard F (2002), Jaulin-Bastard F (2002), Jaulin-Bastard F (2002), Jaulin-Bastard F (2002), Jaulin-Bastard F (2002), Laura RP (2002) 9
XPO1 8 GTSE1 3 affinity chromatography technology Kirli K (2015) 1
CDH1 4 DBN1 1 bioid Guo Z (2014) 1
KCNA5 2 ACTN2 2 two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down Eldstrom J (2003), Maruoka ND (2000), Maruoka ND (2000), Maruoka ND (2000), Maruoka ND (2000), Cukovic D (2001), Cukovic D (2001) 7
FOXO3 1 CTNNB1 30 affinity chromatography technology, affinity chromatography technology Essers MA (2005), Essers MA (2005) 2
SMAD3 1 CHUK 5 affinity chromatography technology Descargues P (2008) 1
SMAD7 1 ACVR2B 0 affinity chromatography technology Kamiya Y (2010) 1
EGLN3 0 FOXO3 1 affinity chromatography technology Rodriguez J (2016) 1
HNRNPL 3 MAP4 8 affinity chromatography technology Fei T (2017) 1
RBX1 2 BTRC 1 affinity chromatography technology, affinity chromatography technology, bioid Tan M (2010), Oshikawa K (2003), Coyaud E (2015) 3
CBL 7 ACTN1 5 affinity chromatography technology Brehme M (2009) 1
ZNF785 0 APC 5 affinity chromatography technology Huttlin EL (2017) 1
MYO19 0 ACTN1 5 affinity chromatography technology Hein MY (2015) 1
PPP1R3A 2 PPP1CA 3 affinity chromatography technology Hauri S (2013) 1
CFTR 5 CTNNB1 30 affinity chromatography technology Pankow S (2015) 1
CERKL 1 ERBIN 5 affinity chromatography technology Huttlin EL (2017) 1
BTRC 1 DBN1 1 two hybrid Vinayagam A (2011) 1
DBN1 1 PPP1CC 2 affinity chromatography technology Hein MY (2015) 1
ERBIN 5 MAPK12 1 unspecified method Boisguerin P (2004) 1
CFTR 5 ABCC4 3 affinity chromatography technology Li C (2007) 1
ERBIN 5 AGTR2 2 unspecified method Boisguerin P (2004) 1
ERBIN 5 SCN4A 3 unspecified method Boisguerin P (2004) 1
HNRNPL 3 LRRC1 1 affinity chromatography technology Fei T (2017) 1
DBN1 1 CLTC 12 affinity chromatography technology Hein MY (2015) 1
MYC 2 BCR 3 affinity chromatography technology Koch HB (2007) 1
ZNF581 0 ERBIN 5 affinity chromatography technology Huttlin EL (2017) 1
SMAD3 1 ZFYVE9 5 affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology Lin HK (2004), Tsukazaki T (1998), Tsukazaki T (1998), Brown KA (2008), Colland F (2004), Qin BY (2002), Qin BY (2002), Huttlin EL (2015), Huttlin EL (2017) 9
EGLN3 0 RPAP1 5 affinity chromatography technology Rodriguez J (2016) 1
XPO1 8 ERBIN 5 affinity chromatography technology Kirli K (2015) 1
XPO1 8 FOXO3 1 affinity chromatography technology Kirli K (2015) 1
ERBIN 5 MPP3 0 unspecified method Boisguerin P (2004) 1
EGLN3 0 BCR 3 affinity chromatography technology Rodriguez J (2016) 1
CTNNB1 30 BTRC 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, enzymatic study, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Yang J (2006), Yang J (2006), Cong F (2003), Kitagawa M (1999), Kitagawa M (1999), Kitagawa M (1999), Hart M (1999), Hart M (1999), Hart M (1999), Su Y (2008), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Liu J (2004), Dorrello NV (2006), Godin JD (2010), Guardavaccaro D (2008), Evrard-Todeschi N (2008), Saha A (2008), Saha A (2008), Chen CH (2012), Wei S (2008), Dehan E (2009), Wang D (2011), Gao D (2011), Li VS (2012), Sahasrabuddhe AA (2014), Mbom BC (2014), Mbom BC (2014), Kovacev J (2014), Gao C (2014), Kluge SF (2013), Chong RA (2014), Herrero-Ruiz J (2014), Zhang L (2012), Coyaud E (2015), Loveless TB (2015), Low TY (2014), Coyaud E (2015), Tseng RC (2015), Wu K (2016), Villalobos V (2010), Pierce NW (2009), Shrestha H (2016), Gu JJ (2016), Vaid M (2011) 46
XPO1 8 MEF2A 1 affinity chromatography technology Kirli K (2015) 1
PKP4 5 PDZD2 5 affinity chromatography technology, pull down, affinity chromatography technology Deguchi M (2000), Deguchi M (2000), Ohno H (2002) 3
TMEM17 0 ATP2B4 5 bioid Gupta GD (2015) 1
EGLN3 0 APC 5 affinity chromatography technology Rodriguez J (2016) 1
ERBIN 5 ATP2B1 6 unspecified method Boisguerin P (2004) 1
CDH1 4 CTNND1 4 two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, bioid Daniel JM (1995), Daniel JM (1995), Ireton RC (2002), Kinch MS (1995), Hazan RB (1998), Bonne S (2003), Piedra J (2003), Piedra J (2003), Shibamoto S (1995), Shibamoto S (1995), Ohkubo T (1999), Ohkubo T (1999), Ishiyama N (2010), Ishiyama N (2010), Ishiyama N (2010), Chen Y (2009), Smyth D (2012), Del Valle-Perez B (2011), Figueiredo J (2013), Ribeiro AS (2013), Pinheiro H (2012), Guo Z (2014) 22
CLTC 12 ZFYVE9 5 pull down Kostaras E (2012) 1
ERBIN 5 MCC 3 unspecified method Boisguerin P (2004) 1
RIPK4 0 ERBIN 5 affinity chromatography technology Rodriguez J (2016) 1
CDH1 4 ARVCF 5 bioid Guo Z (2014) 1
EGLN3 0 CTNNB1 30 affinity chromatography technology Rodriguez J (2016) 1
ZNF408 0 APC 5 affinity chromatography technology Huttlin EL (2017) 1
CFTR 5 ERBIN 5 affinity chromatography technology Wang X (2006) 1
SMAD3 1 SMAD2 5 affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017) 12
ERBIN 5 HRAS 2 affinity chromatography technology Huang YZ (2003) 1
BTRC 1 ERBIN 5 bioid, affinity chromatography technology, affinity chromatography technology Coyaud E (2015), Xie CM (2015), Xie CM (2015) 3
DBN1 1 GTSE1 3 affinity chromatography technology Hein MY (2015) 1
EGLN3 0 DBN1 1 affinity chromatography technology Rodriguez J (2016) 1
SMAD1 0 ERBIN 5 pull down Warner DR (2003) 1
XPO1 8 RPAP1 5 affinity chromatography technology Kirli K (2015) 1
MEF2A 1 SMAD2 5 affinity chromatography technology, pull down Quinn ZA (2001), Quinn ZA (2001) 2
ERBIN 5 MPP1 1 unspecified method Boisguerin P (2004) 1
PPP1CC 2 CLTC 12 two hybrid Esteves SL (2012) 1
KCNA5 2 ATP2B4 5 affinity chromatography technology Huttlin EL (2017) 1
SMAD2 5 ERBIN 5 pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down Warner DR (2003), Xi Q (2008), Brown KA (2008), Dai F (2007), Dai F (2007), Dai F (2007) 6
CDH1 4 DST 13 bioid Guo Z (2014) 1
HNRNPL 3 CASK 18 affinity chromatography technology Fei T (2017) 1
PPP1CA 3 XPO1 8 biochemical Kristensen AR (2012) 1
CLTC 12 PKP4 5 affinity chromatography technology Hein MY (2015) 1
ZNF414 1 CASK 18 affinity chromatography technology Huttlin EL (2017) 1
MYC 2 BTRC 1 affinity chromatography technology, enzymatic study Popov N (2010), Popov N (2010) 2
SMAD2 5 CHUK 5 affinity chromatography technology Descargues P (2008) 1
XPO1 8 CBL 7 affinity chromatography technology Kirli K (2015) 1
SMAD2 5 CTNNB1 30 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Tian YC (2002), Dahle O (2010), Xi Y (2013) 3
SMAD4 9 CTNNB1 30 affinity chromatography technology Tian YC (2002) 1
PPP1CC 2 PPP1CA 3 affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017) 8
RNF7 0 BTRC 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study Tan M (2010), Kuang P (2016), Kuang P (2016), Kuang P (2016) 4
CUL3 17 ERBIN 5 affinity chromatography technology Wimuttisuk W (2014) 1
CFTR 5 CHUK 5 affinity chromatography technology Pankow S (2015) 1
ZNF764 2 ERBIN 5 affinity chromatography technology Huttlin EL (2017) 1
MED4 2 ERBIN 5 bioid Lambert JP (2015) 1
SMAD3 1 ITGB4 11 affinity chromatography technology Brown KA (2008) 1
ERBIN 5 ERBB2 6 pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology Jaulin-Bastard F (2001), Jaulin-Bastard F (2001), Jaulin-Bastard F (2001), Jaulin-Bastard F (2001), Borg JP (2000), Borg JP (2000), Huang YZ (2003) 7
CBL 7 BCR 3 pull down, pull down, affinity chromatography technology, enzymatic study Gaston I (2004), Panchamoorthy G (1996), Brehme M (2009), Tsukahara F (2010) 4
MYC 2 CTNND1 4 affinity chromatography technology Agrawal P (2010) 1
LIMK1 3 ERBIN 5 affinity chromatography technology Hein MY (2015) 1
ZFYVE9 5 CTNNB1 30 two hybrid Colland F (2004) 1
XPO1 8 XRCC3 1 affinity chromatography technology Kirli K (2015) 1
ZNF264 2 TRIM41 6 two hybrid, affinity chromatography technology Rolland T (2014), Huttlin EL (2017) 2
CDH1 4 ERBB2 6 bioid Guo Z (2014) 1
CFTR 5 ATP2B1 6 affinity chromatography technology Pankow S (2015) 1
DBN1 1 PPP1CA 3 affinity chromatography technology Hein MY (2015) 1
SMAD3 1 SMAD4 9 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017) 60
SMAD3 1 RBX1 2 affinity chromatography technology, affinity chromatography technology, two hybrid Fukuchi M (2001), Fukuchi M (2001), Fukuchi M (2001) 3
ERBIN 5 GUCY1A2 2 unspecified method Boisguerin P (2004) 1
CTNND1 4 BTRC 1 affinity chromatography technology, affinity chromatography technology Shrestha H (2016), Shrestha H (2016) 2
ERBIN 5 MAP4 8 unspecified method Boisguerin P (2004) 1
ZNF550 3 TRIM41 6 affinity chromatography technology Huttlin EL (2017) 1
MED4 2 ARHGEF7 3 bioid, affinity chromatography technology Lambert JP (2015), Lambert JP (2015) 2
EGLN3 0 COPB1 0 affinity chromatography technology Rodriguez J (2016) 1
CTNNB1 30 CBL 7 affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology Chitalia V (2013), Chitalia V (2013), Chitalia V (2013), Shivanna S (2015) 4
CDH1 4 ACTN1 5 affinity chromatography technology Hazan RB (1998) 1
CBL 7 SMAD3 1 affinity chromatography technology, affinity chromatography technology Kang JM (2012), Kang JM (2012) 2
HOXC4 1 ERBIN 5 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
ERBIN 5 VIPR2 1 unspecified method Boisguerin P (2004) 1
MYC 2 SMAD3 1 affinity chromatography technology, pull down, two hybrid Feng XH (2002), Feng XH (2002), Feng XH (2002) 3
PPP1CA 3 ZFYVE9 5 two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Esteves SL (2012), Colland F (2004), Colland F (2004), Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017) 6
ERBIN 5 ACVR2A 0 unspecified method Boisguerin P (2004) 1
MYO19 0 ITGB4 11 affinity chromatography technology Hein MY (2015) 1
SMAD2 5 ITGB4 11 affinity chromatography technology Brown KA (2008) 1
HNRNPL 3 ERBB2 6 affinity chromatography technology Fei T (2017) 1
CDH1 4 CBL 7 bioid Guo Z (2014) 1
CUL3 17 PPP1CA 3 affinity chromatography technology Bennett EJ (2010) 1
ERBIN 5 MPP2 0 unspecified method Boisguerin P (2004) 1
SMAD3 1 ERBIN 5 pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down Warner DR (2003), Xi Q (2008), Brown KA (2008), Dai F (2007), Dai F (2007), Dai F (2007) 6
ERBIN 5 CTSG 0 unspecified method Boisguerin P (2004) 1
BTRC 1 RIPK4 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Loveless TB (2015), Loveless TB (2015), Rodriguez J (2016) 3
TMEM17 0 CASK 18 bioid Gupta GD (2015) 1
RBX1 2 ERBIN 5 enzymatic study Kuang P (2016) 1
PKP4 5 CDH1 4 two hybrid, bioid Hatzfeld M (2003), Guo Z (2014) 2
ERBIN 5 SLC5A5 1 unspecified method Boisguerin P (2004) 1
EGLN3 0 CBL 7 affinity chromatography technology Rodriguez J (2016) 1
ERBIN 5 ABCA1 5 unspecified method Boisguerin P (2004) 1
SMAD4 9 FOXO3 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Seoane J (2004), Seoane J (2004), Fu G (2011), Fu G (2011) 4
CUL3 17 HNRNPL 3 affinity chromatography technology Bennett EJ (2010) 1
MYO19 0 PPP1CA 3 affinity chromatography technology Hein MY (2015) 1
CUL3 17 CTNND1 4 affinity chromatography technology Bennett EJ (2010) 1
ZNF550 3 LRRC1 1 affinity chromatography technology Huttlin EL (2017) 1
ERBIN 5 BANF1 0 unspecified method Boisguerin P (2004) 1
CFTR 5 APC 5 affinity chromatography technology Wang X (2006) 1
SMAD3 1 FOXO3 1 affinity chromatography technology, affinity chromatography technology, imaging technique Seoane J (2004), Fu G (2011), Bollinger LM (2014) 3
ERBIN 5 STAT3 0 two hybrid Wang J (2011) 1
HNRNPL 3 CTNND1 4 affinity chromatography technology Fei T (2017) 1
ACTN1 5 ACTN2 2 biochemical Havugimana PC (2012) 1
MYO19 0 ERBIN 5 affinity chromatography technology Hein MY (2015) 1
CTNNB1 30 CHUK 5 affinity chromatography technology, pull down, enzymatic study Lamberti C (2001), Lamberti C (2001), Albanese C (2003) 3
ERBB2 6 XPO1 8 affinity chromatography technology, affinity chromatography technology Giri DK (2005), Giri DK (2005) 2
HNRNPL 3 BCR 3 affinity chromatography technology Fei T (2017) 1
ZNF414 1 ERBIN 5 affinity chromatography technology Huttlin EL (2017) 1
CFTR 5 ACTN1 5 affinity chromatography technology Pankow S (2015) 1
ZNF408 0 TRIM41 6 affinity chromatography technology Huttlin EL (2017) 1
AZU1 0 STAT3 0 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
CDH1 4 MAP4 8 bioid Guo Z (2014) 1
FOXO3 1 BTRC 1 affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique, pull down Tsai WB (2010), Tsai WB (2010), Tsai WB (2010), Tsai WB (2010), Tsai WB (2010) 5
XPO1 8 SMAD4 9 affinity chromatography technology Kirli K (2015) 1
ERBIN 5 KCNA4 5 pull down, unspecified method Jaulin-Bastard F (2001), Boisguerin P (2004) 2
HNRNPL 3 ERBIN 5 affinity chromatography technology Fei T (2017) 1
SMAD4 9 ERBIN 5 pull down Warner DR (2003) 1
ZNF785 0 CASK 18 affinity chromatography technology Huttlin EL (2017) 1
EGLN3 0 PPP1CC 2 affinity chromatography technology Rodriguez J (2016) 1
SMAD2 5 SMAD1 0 affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017) 4
SMAD7 1 MYC 2 affinity chromatography technology, affinity chromatography technology Kim TA (2013), Kim TA (2013) 2
ERBIN 5 COPB1 0 unspecified method Boisguerin P (2004) 1
CHUK 5 ERBIN 5 enzymatic study Marinis JM (2012) 1
CHUK 5 MYC 2 affinity chromatography technology, affinity chromatography technology Yeh PY (2011), Yeh PY (2011) 2
PPP1CA 3 LRRC1 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017) 3
PDZD2 5 ERBIN 5 affinity chromatography technology Ohno H (2002) 1
KCNA5 2 KCNA4 5 affinity chromatography technology Nitabach MN (2001) 1
RIPK4 0 XPO1 8 affinity chromatography technology Rodriguez J (2016) 1