Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
MAPK1 5594 SB-220025 CHEMBL274064 DrugBank 10592235
MAPK1 5594 LEVODOPA CHEMBL1009 NCI 16139809
MAPK1 5594 OLOMOUCINE CHEMBL280074 DrugBank 10592235
MAPK1 5594 CHEMBL369507 CHEMBL369507 DrugBank 17139284, 17016423, 10592235
MAPK1 5594 CHIR-99021 CHEMBL412142 inhibitor GuideToPharmacologyInteractions
MAPK1 5594 URACIL CHEMBL566 NCI 17076658
MAPK1 5594 Refametinib CHEMBL2138601 TdgClinicalTrial
MAPK1 5594 CHEMBL1229592 CHEMBL1229592 CIViC 22961667
MAPK1 5594 MK-8353 CHEMBL3545001 inhibitor ChemblInteractions
MAPK1 5594 ISOPRENALINE CHEMBL1160723 inducer DrugBank 15138589, 15292328, 20732414, 12963636, 15689414, 13679574
MAPK1 5594 CHEMBL259551 CHEMBL259551 DrugBank 10592235
MAPK1 5594 SB-203580 CHEMBL10 DrugBank 10592235
MAPK1 5594 GDC-0994 CHEMBL3544964 inhibitor ChemblInteractions
MAPK1 5594 ARSENIC TRIOXIDE CHEMBL1200978 inducer TdgClinicalTrial, DrugBank 12426127, 12529330
MAPK1 5594 CHEMBL219841 CHEMBL219841 DrugBank 10592235
MAPK1 5594 CHEMBL387385 CHEMBL387385 DrugBank 10592235
MAPK1 5594 HYPOTHEMYCIN CHEMBL471474 DrugBank 10592235
MAPK1 5594 TURPENTINE CHEMBL2074846 DrugBank
MAPK1 5594 Ulixertinib CHEMBL3545022 inhibitor GuideToPharmacologyInteractions, ChemblInteractions
MAPK1 5594 BUMETANIDE CHEMBL1072 NCI 11807827
MAPK1 5594 BENZOQUINONE CHEMBL8320 NCI 15652497
MAPK1 5594 REBAMIPIDE CHEMBL1697771 NCI 17171453
MAPK1 5594 GONADOTROPIN, CHORIONIC CHEMBL1201509 NCI 15242988
MAPK1 5594 DOXIFLURIDINE CHEMBL1130 NCI 12408764
MAPK1 5594 MEDRONIC ACID CHEMBL180570 NCI 15590626
MAPK1 5594 URSODIOL CHEMBL1551 NCI 14747693
MAPK1 5594 ERLOTINIB CHEMBL553 CIViC 26181029
MAPK1 5594 IROFULVEN CHEMBL118218 NCI 12014623
MAPK1 5594 ETHER CHEMBL16264 NCI 16081674

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
MAPK1 rs6928 C antidepressants efficacy no Or people with major depressive disorder OR bipolar disorder. No significant difference in allele or genetoype frequencies were seen between patients who were or were not resistant, responsive or entered remission while taking antidepressants. Please refer to paper for definitions of a resistant, response and remittent patient. Allele C is not associated with response to antidepressants in people with Depressive Disorder, Major as compared to allele G. 23537502 1183703934
MAPK1 rs13515 C antidepressants efficacy no Or people with major depressive disorder OR bipolar disorder. No significant difference in allele or genotype frequencies were seen between patients who were or were not resistant, responsive or entered remission while taking antidepressants. Please refer to paper for definitions of a resistant, response and remittent patient. Allele C is not associated with response to antidepressants in people with Depressive Disorder, Major as compared to allele T. 23537502 1183704035
MAPK1 rs8136867 A antidepressants efficacy no No significant difference in allele or genotype frequencies were seen between patients who were or were not resistant, responsive or entered remission while taking antidepressants. Please refer to paper for definitions of a resistant, response and remittent patient. Allele A is not associated with response to antidepressants in people with Depressive Disorder, Major as compared to allele G. 23537502 1183704039
MAPK1 rs8136867 AG antidepressants efficacy yes Patients with major depressive disorder OR bipolar disorder. Subjects with the AG genotype are more likely to show remission. Non-remitters were defined as having a Hamilton Depression Rating Scale (HDRS) score of > 7 after at least one adequate antidepressant trial during the current or most recent depressive episode. No significant differences were seen when considering patients' resistance or responsiveness (please see paper for definitions of these). Genotype AG is associated with increased response to antidepressants in people with Mental Disorders. 23537502 1183704069
MAPK1 rs3729910 G glibenclamide efficacy yes No allele was given for the association, so the minor allele from dbSNP at this location was used. Response to treatment was measured as fasting plasma glucose below 7 mmol/L change after 1-year of treatment. Allele G is associated with increased response to glibenclamide in people with as compared to allele A. 27403931 1448123633
MAPK1 rs1803545 A glibenclamide efficacy yes No allele was given for the association, so the minor allele from dbSNP at this location was used. Response to treatment was measured as fasting plasma glucose below 7 mmol/L change after 1-year of treatment. Allele A is associated with increased response to glibenclamide in people with as compared to allele G. 27403931 1448123697