PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SMG9	2	DCAF1	5	affinity chromatography technology	Hein MY (2015)	1
SMG1	7	SMG8	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Yamashita A (2009), Yamashita A (2009), Yamashita A (2009), Izumi N (2010)	4
UPF1	8	SMG9	2	affinity chromatography technology	Yamashita A (2009)	1
RBM8A	2	SMG8	2	affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Izumi N (2010)	2
EPHA1	5	SMG9	2	affinity chromatography technology	Huttlin EL (2017)	1
EPHA1	5	SMG1	7	affinity chromatography technology	Huttlin EL (2017)	1
UPF1	8	RUVBL1	2	affinity chromatography technology, affinity chromatography technology	Izumi N (2010), Cloutier P (2017)	2
TRAF2	1	SMG9	2	two hybrid	Rolland T (2014)	1
KRT31	0	SMG9	2	two hybrid	Rolland T (2014)	1
SMG1	7	SMG9	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Yamashita A (2009), Yamashita A (2009), Yamashita A (2009), Izumi N (2010), Hein MY (2015)	6
SMG9	2	SMG8	2	affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Hein MY (2015)	2
UPF1	8	RBM8A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Yamashita A (2009), Kashima I (2006), Izumi N (2010), Izumi N (2010)	5
CNTROB	6	SMG9	2	bioid	Gupta GD (2015)	1
RUVBL1	2	SMG8	2	affinity chromatography technology	Izumi N (2010)	1
SMG1	7	UPF1	8	enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yamashita A (2001), Yamashita A (2001), Yamashita A (2001), Yamashita A (2009), Yamashita A (2009), Ivanov PV (2008), Isken O (2008), Kashima I (2006), Kashima I (2006), Kashima I (2006), Izumi N (2010)	11
HIF1AN	0	SMG9	2	affinity chromatography technology	Rodriguez J (2016)	1
RBM8A	2	SMG1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Kashima I (2006), Kashima I (2006), Izumi N (2010), Izumi N (2010)	5
STIL	3	UPF1	8	bioid	Gupta GD (2015)	1
RBM8A	2	SMG9	2	affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Izumi N (2010)	2
SMG9	2	PRPSAP1	0	affinity chromatography technology	Hein MY (2015)	1
RBM8A	2	RUVBL1	2	affinity chromatography technology	Izumi N (2010)	1
SMG1	7	RUVBL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Izumi N (2010), Izumi N (2010), Izumi N (2010)	3
UPF1	8	SMG8	2	affinity chromatography technology	Yamashita A (2009)	1
TRIM23	3	SMG9	2	two hybrid	Rolland T (2014)	1
EPHA1	5	SMG8	2	affinity chromatography technology	Huttlin EL (2017)	1
STIL	3	SMG9	2	bioid	Gupta GD (2015)	1
SMG9	2	DDX11	1	affinity chromatography technology	Hein MY (2015)	1
RUVBL1	2	SMG9	2	affinity chromatography technology	Izumi N (2010)	1