PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK13	1	HTRA2	1	enzymatic study	Plun-Favreau H (2007)	1
APP	1	MAPT	1	pull down, unspecified method	Guo JP (2006), Guo JP (2006)	2
MAPK8IP2	5	VCP	6	two hybrid	Vinayagam A (2011)	1
ATF2	1	SMAD4	9	two hybrid, pull down, affinity chromatography technology	Sano Y (1999), Sano Y (1999), Sano Y (1999)	3
MAPK13	1	SQSTM1	0	enzymatic study	Linares JF (2015)	1
VCP	6	ANKLE2	5	affinity chromatography technology	Fogeron ML (2013)	1
FGF12	4	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
MAPKAPK3	0	APP	1	pull down	Olah J (2011)	1
MAPK12	1	MBP	0	enzymatic study	Plun-Favreau H (2007)	1
ATF2	1	APP	1	pull down	Olah J (2011)	1
SQSTM1	0	MBP	0	pull down	Pridgeon JW (2004)	1
VCP	6	MAPK13	1	affinity chromatography technology	Yu CC (2013)	1
MAPK13	1	POTEF	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
GPX4	0	MAPK13	1	two hybrid	Wang J (2011)	1
MAPK13	1	FGF12	4	enzymatic study	Schoorlemmer J (2002)	1
MAPK13	1	MAPKAPK3	0	imaging technique	Chen TC (2014)	1
HTRA2	1	VCP	6	affinity chromatography technology	Raman M (2015)	1
MAPK8IP2	5	MAPK13	1	affinity chromatography technology, affinity chromatography technology	Schoorlemmer J (2002), Schoorlemmer J (2001)	2
MAPK13	1	MAP3K4	1	imaging technique	Chen TC (2014)	1
MAPK12	1	HTRA2	1	enzymatic study	Plun-Favreau H (2007)	1
MAPK13	1	MAPT	1	enzymatic study	Goedert M (1997)	1
MAPK13	1	MBP	0	enzymatic study	Plun-Favreau H (2007)	1
MAPK13	1	APP	1	pull down	Olah J (2011)	1
MAPT	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Babu JR (2005), Babu JR (2005), Rui YN (2015)	3
MAPK13	1	ANKLE2	5	two hybrid	Wang J (2008)	1
SMAD4	9	MAPK13	1	two hybrid	Colland F (2004)	1
MAPK13	1	ATF2	1	enzymatic study	Schoorlemmer J (2002)	1
MAPK13	1	AKIP1	3	two hybrid	Wang J (2008)	1
MAPK8IP2	5	FGF12	4	affinity chromatography technology, two hybrid	Schoorlemmer J (2001), Grossmann A (2015)	2
MAPK12	1	MAPK13	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APP	1	MAPK8IP2	5	affinity chromatography technology	Muresan Z (2005)	1