PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP2K7	5	JUN	0	enzymatic study	Sundarrajan M (2003)	1
MAP3K4	1	GADD45B	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takekawa M (1998), Takekawa M (1998), Aissouni Y (2005), Huttlin EL (2017)	4
MYC	2	XPO1	8	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Kirli K (2015)	2
VRK2	1	MAP2K7	5	affinity chromatography technology	Blanco S (2008)	1
MYC	2	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Gregory MA (2003), Gregory MA (2003), Arnold HK (2009), Zhou Z (2014)	4
ATF4	2	JUN	0	pull down, two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, imaging technique	Hai T (1991), Bandyopadhyay S (2010), Reinke AW (2013), Reinke AW (2013), Chen TC (2014)	5
MAP3K1	4	RPL30	1	affinity chromatography technology	Bouwmeester T (2004)	1
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
MAPK9	3	MAP2K7	5	unspecified method, enzymatic study	Ho DT (2006), Enomoto A (2003)	2
ALK	8	MAP3K1	4	affinity chromatography technology, affinity chromatography technology	Crockett DK (2004), Crockett DK (2004)	2
MAPK8IP3	9	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Matsuura H (2002), Matsuura H (2002), Matsuura H (2002), Matsuura H (2002), Song JJ (2004)	5
LAMP3	1	MAP2K7	5	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K11	7	MAP2K7	5	enzymatic study, enzymatic study	Merritt SE (1999), Zhang H (2004)	2
MAP2K7	5	MAPK8IP1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Yasuda J (1999), Yasuda J (1999), Santos CR (2006), Blanco S (2008), Blanco S (2008)	5
HSP90AA1	7	MAP3K12	2	affinity chromatography technology	Taipale M (2012)	1
DUSP19	0	MAPK1	1	affinity chromatography technology	Li X (2016)	1
MAP3K7	2	MAP2K4	3	enzymatic study, affinity chromatography technology	Ge B (2003), Li MG (2003)	2
RANBP2	9	MAP2K7	5	enzymatic study, affinity chromatography technology	Zhu T (2016), Zhu T (2016)	2
JUN	0	MYC	2	affinity chromatography technology	Levy S (2010)	1
GSK3B	1	JUN	0	enzymatic study, imaging technique	Chen BK (2007), Chen TC (2014)	2
GADD45B	1	MAP3K5	1	affinity chromatography technology, pull down	Papa S (2004), Papa S (2004)	2
BRAF	12	MAPK1	1	enzymatic study, genetic interference, enzymatic study	Ren JG (2008), Hart T (2015), Smith BD (2015)	3
DUSP19	0	MAPK9	3	enzymatic study	Zama T (2002)	1
HSP90AA1	7	BRAF	12	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Eisenhardt AE (2016)	2
ALK	8	MAP3K5	1	affinity chromatography technology	Crockett DK (2004)	1
SNW1	0	CDC5L	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang C (2003), Wan C (2015), Lleres D (2010), Lleres D (2010)	4
MAP2K7	5	MAP3K5	1	affinity chromatography technology	Zama T (2002)	1
GSK3B	1	MAP3K4	1	enzymatic study	Abell AN (2007)	1
JUN	0	MAPK1	1	affinity chromatography technology, enzymatic study, pull down	Kumar NV (2001), Zuniga A (1999), Zuniga A (1999)	3
HSP90AA1	7	MYC	2	affinity chromatography technology	Carystinos GD (2003)	1
MAPK9	3	MAPK8	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
ALK	8	MAP2K7	5	affinity chromatography technology	Crockett DK (2004)	1
MAP3K7	2	HSP90AA1	7	affinity chromatography technology	Liu XY (2008)	1
MAPK1	1	ILKAP	2	biochemical	Wan C (2015)	1
HSP90AA1	7	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1
MAP3K11	7	MAPK8IP1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Yasuda J (1999), Yasuda J (1999), Humphrey RK (2013), Humphrey RK (2013)	4
MAP3K2	1	MAP2K7	5	affinity chromatography technology, biochemical, enzymatic study	Cheng J (2000), Cheng J (2000), Takeda AN (2014)	3
MAP2K7	5	ILKAP	2	biochemical	Wan C (2015)	1
MAP2K4	3	MAPK9	3	two hybrid, affinity chromatography technology, pull down	Vinayagam A (2011), Li Y (2012), Ho DT (2003)	3
C4BPB	1	MAP2K7	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MYC	2	MAP3K13	1	genetic interference	Toyoshima M (2012)	1
MAP3K1	4	JUN	0	enzymatic study	Park KJ (2003)	1
ANTXR1	3	MAP2K7	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP2K4	3	MAPK8	3	pull down, pull down, enzymatic study, genetic interference, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Lee CM (2002), Park HS (2002), Chen Z (2001), Tournier C (1997), Cheng J (2000), Deacon K (1997), Xia Y (1998), Xia Y (1998), Ho DT (2006), Song JJ (2005), Sundarrajan M (2003), Ho DT (2003), Ho DT (2003)	13
FBXO6	0	MAP2K7	5	affinity chromatography technology	Liu B (2012)	1
VSIG4	1	MAP2K7	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP2K4	3	MAP3K5	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Ryoo K (2004), Song JJ (2004), Kim EK (2007), Zhang H (2004)	4
MAPK8	3	JUN	0	enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, two hybrid, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study	Ishitani T (2003), Nishitoh H (1998), Derijard B (1994), Derijard B (1994), Yazgan O (2002), Tada K (2001), Meyer CF (1996), Cano E (1995), Cano E (1995), Trivedi AK (2007), Zhu F (2006), Zuniga A (1999), Zuniga A (1999), Higashimoto T (2008), Garcia-Guzman M (2000), Singhirunnusorn P (2005), Hofmann TG (2005), Lewis J (2004), Jeon YJ (2009), Yamashita M (2008), Ryoo K (2004), Abell AN (2005), Burns K (1998), Hirano T (2002), Gravestein LA (1998), Dadgostar H (2003), Han YH (2006), Kolluri SK (2003), Chen LY (2003), Manna SK (2010), Gallagher ED (2002), Liu HP (2011), Xia Y (1998), Funakoshi-Tago M (2005), Ho DT (2006), Wang J (2000), Choi HK (2011), Chang TS (2003), Yao K (2009), Chang TS (2003), Dai R (2000), Gupta S (1996), Gupta S (1996), Sundarrajan M (2003), Kallunki T (1994), Kallunki T (1994), Wasserman T (2010), Blonska M (2007), Lee KH (2005), Kadoya T (2005), Katagiri C (2006), Yao K (2007), Wu X (2007), Kato T (2008), Cavigelli M (1995), Katagiri C (2006), Choi BY (2005), Choi BY (2005), Yuan ZQ (2003), Phelan DR (2001), Eliopoulos AG (2006), Hayashi T (2007), Zhang J (2013), Li X (2002), Kendrick TS (2004), Holzberg D (2003), Grau R (2004), Hernandez M (2000), Hwang SG (2014), Larsson H (1999), Rausch O (1997), Morley SJ (2000), Ho JM (2002), Shkoda A (2012), Pop M (2004), Chang HY (1999)	76
HSP90AA1	7	ALDOA	0	affinity chromatography technology	Falsone SF (2005)	1
GSK3B	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
MAPK9	3	MAPK8IP1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yasuda J (1999), Yasuda J (1999), Whitmarsh AJ (1998), Song JJ (2005), Huttlin EL (2017)	5
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
BSG	1	MAP2K7	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NRAS	1	MAP2K7	5	affinity chromatography technology	Mori S (1995)	1
MAP2K4	3	MAPK1	1	pull down	Ho DT (2003)	1
MAP2K7	5	GSK3B	1	biochemical	Wan C (2015)	1
VRK2	1	MAPK8	3	affinity chromatography technology	Blanco S (2008)	1
MAP3K5	1	MAP3K7	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mochida Y (2000), Mochida Y (2000), Mochida Y (2000), Kim SY (2012), Kim SY (2012)	5
MAP2K4	3	JUN	0	enzymatic study	Sundarrajan M (2003)	1
MAPK1	1	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Karandikar M (2000), Karandikar M (2000), Gallagher ED (2004), Tu Z (2003), Loke J (2014)	5
SPACA1	1	ANTXR1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GSK3B	1	ILKAP	2	biochemical	Wan C (2015)	1
CDC5L	2	RANBP2	9	affinity chromatography technology	Lleres D (2010)	1
SPACA1	1	MAP2K7	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP3K4	1	MAP2K4	3	enzymatic study, pull down	Chan-Hui PY (1998), Takekawa M (2005)	2
SNW1	0	RANBP2	9	affinity chromatography technology	Lleres D (2010)	1
MAPK8IP1	7	MAP3K7	2	affinity chromatography technology, biochemical	Blanco S (2008), Blanco S (2008)	2
ALK	8	DUSP19	0	two hybrid	Yao Z (2017)	1
MAPK9	3	MAPK8IP2	5	affinity chromatography technology, pull down, pull down	Yasuda J (1999), Yasuda J (1999), Yasuda J (1999)	3
PROZ	0	MAP2K7	5	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	MAP3K20	1	affinity chromatography technology	Kirli K (2015)	1
LRRK2	5	MAP2K4	3	enzymatic study	Gloeckner CJ (2009)	1
MAPK9	3	JUN	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, enzymatic study	Kallunki T (1996), Natoli G (1997), Chin AI (1999), Ho DT (2006), Yao K (2009), Gupta S (1996), Gupta S (1996), Kallunki T (1994), Kallunki T (1994), Wasserman T (2010), Blonska M (2007), Katagiri C (2006), Yao K (2007), Phelan DR (2001), Ho DT (2003), Camps M (1998)	16
MAP3K20	1	MAP2K7	5	affinity chromatography technology	Huang CY (2004)	1
PCDHGA5	2	MAP2K7	5	affinity chromatography technology	Huttlin EL (2017)	1
LRP1	25	MAPK8IP1	7	two hybrid, pull down, two hybrid	Gotthardt M (2000), Gotthardt M (2000), Kajiwara Y (2010)	3
IL13RA2	0	MAP2K7	5	affinity chromatography technology	Huttlin EL (2017)	1
GSK3B	1	HSP90AA1	7	enzymatic study	Muller P (2012)	1
MAP3K3	3	MAP2K7	5	enzymatic study	Takeda AN (2014)	1
XPO1	8	MAP3K7	2	affinity chromatography technology	Kirli K (2015)	1
GSK3B	1	MAP3K1	4	affinity chromatography technology, pull down	Kim JW (2003), Kim JW (2003)	2
MAPK9	3	BCL10	0	affinity chromatography technology, affinity chromatography technology	Blonska M (2007), Blonska M (2007)	2
MAP2K4	3	MAP2K7	5	genetic interference, affinity chromatography technology, affinity chromatography technology	Fleming Y (2000), Sundarrajan M (2003), Sundarrajan M (2003)	3
MAP3K1	4	MAP2K7	5	affinity chromatography technology, pull down	Tu Z (2003), Takekawa M (2005)	2
ILKAP	2	MAPK14	0	enzymatic study	Zhang X (2017)	1
MAPK8	3	MAP3K7	2	affinity chromatography technology, pull down	Sanna MG (2002), Sanna MG (2002)	2
MAP2K7	5	MAP3K4	1	pull down	Takekawa M (2005)	1
CDC5L	2	HSP90AA1	7	affinity chromatography technology	Lleres D (2010)	1
ALDOA	0	HSPE1	0	biochemical	Wan C (2015)	1
MAPK8IP3	9	MAP3K1	4	affinity chromatography technology	Ito M (1999)	1
XPO1	8	MAP3K3	3	affinity chromatography technology	Kirli K (2015)	1
CDC5L	2	MAP2K4	3	affinity chromatography technology	Lleres D (2010)	1
MAP3K2	1	MAP2K4	3	affinity chromatography technology, enzymatic study, enzymatic study	Cheng J (2000), Deacon K (1997), Enomoto A (2008)	3
MYC	2	MAPK1	1	pull down, pull down	Jin Z (2004), Gupta S (1994)	2
MAP2K7	5	ALDOA	0	biochemical	Wan C (2015)	1
MAP2K7	5	HSPE1	0	biochemical	Wan C (2015)	1
DLK1	2	MAP2K7	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP3K3	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Fang S (2009), Fang S (2009)	2
ELAVL1	0	DUSP19	0	affinity chromatography technology	Abdelmohsen K (2009)	1
HSP90AA1	7	LRRK2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ding X (2009), Ding X (2009), Nichols RJ (2010), Zach S (2010), Daechsel JC (2007), Wang L (2008), Sen S (2009), Rudenko IN (2012), Gloeckner CJ (2006), Imai Y (2015)	10
BRAF	12	WDR6	6	affinity chromatography technology	Eisenhardt AE (2016)	1
XPO1	8	MAP2K7	5	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	BCL10	0	affinity chromatography technology	Kirli K (2015)	1
SNW1	0	HSP90AA1	7	affinity chromatography technology	Lleres D (2010)	1
MYC	2	RANBP2	9	affinity chromatography technology	Koch HB (2007)	1
MAP3K13	1	MAP2K7	5	enzymatic study	Ikeda A (2001)	1
MAPK14	0	MAPK8	3	affinity chromatography technology	Chan PM (2008)	1
MAPK1	1	MAP2K7	5	unspecified method, enzymatic study, enzymatic study	Ho DT (2006), Mori S (1995), Saito T (2004)	3
MAP3K11	7	MAP2K4	3	enzymatic study	Merritt SE (1999)	1
ELAVL1	0	ANTXR1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
JUN	0	HSP90AA1	7	two hybrid, pull down	Bandyopadhyay S (2010), Miyamoto-Sato E (2010)	2
SNW1	0	ELAVL1	0	affinity chromatography technology	Lleres D (2010)	1
MAP3K1	4	MAPK8	3	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Xu S (1997), Xu S (1997), Xu S (1997), Xu S (1997), Ryoo K (2004), Tu Z (2003), Sun BK (2011), Gallagher ED (2002), Chen TC (2014)	9
MAPK14	0	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAPK8IP3	9	MAP3K11	7	pull down	Kelkar N (2000)	1
MAP3K11	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang H (2004), Zhang H (2004), Blessing NA (2014)	3
MAP3K12	2	MAPK8IP1	7	affinity chromatography technology, pull down	Yasuda J (1999), Yasuda J (1999)	2
BSG	1	HSP90AA1	7	affinity chromatography technology	Wu B (2017)	1
ELAVL1	0	MAP3K12	2	affinity chromatography technology	Abdelmohsen K (2009)	1
FBXO6	0	BSG	1	affinity chromatography technology	Liu B (2012)	1
MAP3K3	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Yamazaki K (2009), Yamazaki K (2009), Blonska M (2005), Blonska M (2005), Blonska M (2005)	5
ELAVL1	0	NRAS	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MAPK8IP3	9	MAPK8IP1	7	affinity chromatography technology	Huttlin EL (2017)	1
MAPK8IP1	7	MAP3K13	1	affinity chromatography technology	Ikeda A (2001)	1
DUSP19	0	MAP3K5	1	affinity chromatography technology, genetic interference	Zama T (2002), Zama T (2002)	2
MAPK8IP3	9	MAPK8	3	pull down, pull down, enzymatic study	Ito M (1999), Kelkar N (2000), Kelkar N (2000)	3
MAP3K3	3	MAP2K4	3	enzymatic study, affinity chromatography technology, pull down	Deacon K (1997), Hernandez ED (2014), Hernandez ED (2014)	3
MAPK14	0	MAP2K7	5	enzymatic study	Tournier C (1997)	1
MAP3K2	1	MAPK8	3	affinity chromatography technology, biochemical	Cheng J (2000), Cheng J (2000)	2
FBXO6	0	LRP1	25	affinity chromatography technology	Liu B (2012)	1
ALK	8	MAP3K4	1	affinity chromatography technology	Crockett DK (2004)	1
BRAF	12	MAP2K7	5	enzymatic study	Eisenhardt AE (2016)	1
MAP3K7	2	MAP2K7	5	imaging technique	Chen TC (2014)	1
MAPK8	3	HSP90AA1	7	affinity chromatography technology	Nieto-Miguel T (2008)	1
SNW1	0	MAP2K7	5	affinity chromatography technology	Lleres D (2010)	1
MAPK8IP3	9	MAPK9	3	pull down, pull down	Ito M (1999), Kelkar N (2000)	2
MAP3K4	1	MAPK8	3	enzymatic study, affinity chromatography technology	Sun BK (2011), Hein MY (2015)	2
GADD45B	1	MAP2K7	5	affinity chromatography technology, pull down	Papa S (2004), Papa S (2004)	2
MAP3K11	7	MAPK8IP2	5	affinity chromatography technology, pull down, pull down	Yasuda J (1999), Yasuda J (1999), Yasuda J (1999)	3
MYC	2	MAP3K20	1	affinity chromatography technology	Hein MY (2015)	1
ALK	8	MAPK1	1	affinity chromatography technology	Crockett DK (2004)	1
CDC5L	2	ELAVL1	0	affinity chromatography technology	Lleres D (2010)	1
ALK	8	MAPK8IP3	9	affinity chromatography technology	Crockett DK (2004)	1
ELAVL1	0	MYC	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TPCN2	0	MAP2K7	5	affinity chromatography technology	Huttlin EL (2017)	1
SNW1	0	MYC	2	affinity chromatography technology, affinity chromatography technology	Bres V (2009), Bres V (2009)	2
LAMP3	1	MAPK8	3	affinity chromatography technology	Huttlin EL (2017)	1
CDC5L	2	MAP2K7	5	affinity chromatography technology	Lleres D (2010)	1
MYC	2	ALDOA	0	genetic interference	Toyoshima M (2012)	1
MYC	2	MAP2K7	5	genetic interference	Toyoshima M (2012)	1
NRAS	1	BRAF	12	affinity chromatography technology, affinity chromatography technology, two hybrid	Mori S (1995), Eisenhardt AE (2016), Jaitner BK (1997)	3
HSP90AA1	7	MAP2K7	5	affinity chromatography technology	Taipale M (2012)	1
MAPK8	3	MAP2K7	5	enzymatic study, enzymatic study, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study	Tournier C (1997), Tournier C (1997), Tournier C (1997), Cheng J (2000), Ho DT (2006), Ho DT (2006), Ho DT (2006), Ho DT (2006), Enomoto A (2003), Takeda AN (2014), Sundarrajan M (2003), Chen TC (2014), Zhu T (2016), Zhu T (2016)	14
XPO1	8	GSK3B	1	affinity chromatography technology	Kirli K (2015)	1
MAPK8	3	MYC	2	enzymatic study, pull down, affinity chromatography technology	Noguchi K (1999), Noguchi K (1999), Noguchi K (1999)	3
MAPK8IP2	5	VRK2	1	pull down	Blanco S (2008)	1
MAP2K7	5	WDR6	6	affinity chromatography technology	Wasserman T (2010)	1
ADAM32	3	MAP2K7	5	affinity chromatography technology	Huttlin EL (2017)	1
DUSP19	0	MAP2K7	5	affinity chromatography technology, pull down	Zama T (2002), Zama T (2002)	2
MAP3K12	2	MAP2K7	5	enzymatic study, affinity chromatography technology	Merritt SE (1999), Merritt SE (1999)	2
GSK3B	1	MAP3K11	7	affinity chromatography technology	Pilot-Storck F (2010)	1
HSP90AA1	7	ALK	8	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
ELAVL1	0	BCL10	0	affinity chromatography technology	Abdelmohsen K (2009)	1
MAP3K2	1	MAP3K3	3	pull down, affinity chromatography technology	Takeda AN (2014), Hein MY (2015)	2
MAP2K4	3	MAPK14	0	enzymatic study, affinity chromatography technology, pull down	Deacon K (1997), Xia Y (1998), Xia Y (1998)	3
MAP2K7	5	RPL30	1	two hybrid	Wang J (2011)	1
ELAVL1	0	GSK3B	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MAP2K7	5	BCL10	0	affinity chromatography technology	Blonska M (2007)	1
MAPK8IP1	7	VRK2	1	affinity chromatography technology, affinity chromatography technology	Blanco S (2008), Blanco S (2008)	2
MAPK8IP3	9	MAP2K4	3	affinity chromatography technology, affinity chromatography technology	Ito M (1999), Matsuura H (2002)	2
ELAVL1	0	MAP2K7	5	affinity chromatography technology	Abdelmohsen K (2009)	1
MAPK8IP1	7	JUN	0	affinity chromatography technology	Nishitani Y (2006)	1
MAP3K1	4	MAP2K4	3	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study	Cheng J (2000), Gallagher ED (2004), Ryoo K (2004), Ryoo K (2004), Tu Z (2003), Takekawa M (2005), Xia Y (1998), Xia Y (1998), Gallagher ED (2002), Xia Y (1998), Chen Z (2006), Ahn JS (2016)	12
MAPK8IP1	7	MAPK8	3	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Whitmarsh AJ (1998), Cai Y (2002), Ho DT (2006), Song JJ (2005), Blanco S (2008), Blanco S (2008), Nishitani Y (2006), Huttlin EL (2017)	8
FBXO6	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Taipale M (2012)	2
XPO1	8	MAP3K1	4	affinity chromatography technology	Kirli K (2015)	1
MAP2K7	5	MAPK8IP2	5	affinity chromatography technology, pull down, pull down, pull down	Yasuda J (1999), Yasuda J (1999), Yasuda J (1999), Negri S (2000)	4
MAPK1	1	GSK3B	1	affinity chromatography technology, pull down, enzymatic study	Ding Q (2005), Ding Q (2005), Ding Q (2005)	3
LRP1	25	MAPK8IP2	5	two hybrid, pull down	Gotthardt M (2000), Gotthardt M (2000)	2
MAP3K1	4	MAPK9	3	two hybrid, pull down	Gallagher ED (2004), Gallagher ED (2002)	2
ELAVL1	0	MAP3K20	1	affinity chromatography technology	Abdelmohsen K (2009)	1
IL13RA2	0	ANTXR1	3	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	MAP3K5	1	affinity chromatography technology	Taipale M (2012)	1
HSP90AA1	7	MAP3K2	1	affinity chromatography technology	Taipale M (2012)	1
MAPK8IP1	7	MAPK8IP2	5	affinity chromatography technology, pull down, affinity chromatography technology	Yasuda J (1999), Yasuda J (1999), Huttlin EL (2017)	3
MAPK8IP3	9	MAPK8IP2	5	pull down, pull down, affinity chromatography technology	Kelkar N (2000), Kelkar N (2000), Huttlin EL (2017)	3
MAPK14	0	JUN	0	enzymatic study	Thakur N (2014)	1
MAP3K7	2	BCL10	0	affinity chromatography technology	Blonska M (2007)	1
VRK2	1	MAP3K7	2	affinity chromatography technology	Blanco S (2008)	1
MAPK8IP3	9	MAP2K7	5	pull down, affinity chromatography technology	Kelkar N (2000), Matsuura H (2002)	2
LPXN	4	MAP2K7	5	two hybrid	Wang J (2011)	1
HSP90AA1	7	HSPE1	0	biochemical	Wan C (2015)	1
ATF4	2	MAP2K7	5	two hybrid	Wang J (2011)	1
MAP3K12	2	MAPK8IP2	5	affinity chromatography technology, pull down	Yasuda J (1999), Yasuda J (1999)	2
LRP1	25	MAP2K7	5	affinity chromatography technology	Huttlin EL (2017)	1
LRRK2	5	MAP2K7	5	enzymatic study, affinity chromatography technology, enzymatic study	Gloeckner CJ (2009), Hsu CH (2010), Hsu CH (2010)	3