PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HSPA5	0	STIP1	1	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
PRNP	4	RNPC3	1	pull down	Satoh J (2009)	1
PRNP	4	HSP90AA1	7	affinity chromatography technology	Wu GR (2017)	1
SRRM2	18	PRNP	4	affinity chromatography technology	McCracken S (2005)	1
PRNP	4	ZBED3	0	affinity chromatography technology	Wu GR (2017)	1
AMFR	2	PRNP	4	affinity chromatography technology	Lee JH (2017)	1
CYLD	2	HSPA4	3	affinity chromatography technology	Elliott PR (2016)	1
PRNP	4	100131997	0	pull down	Satoh J (2009)	1
PRNP	4	HSPA5	0	pull down	Jin T (2000)	1
PSMA3	1	YWHAQ	0	pull down, affinity chromatography technology	Wang B (2010), Wang B (2010)	2
CYLD	2	SRRM2	18	affinity chromatography technology	Elliott PR (2016)	1
CYLD	2	RPSA	2	affinity chromatography technology	Elliott PR (2016)	1
PRNP	4	CNP	2	pull down	Satoh J (2009)	1
HSPA5	0	HSPA4	3	biochemical	Havugimana PC (2012)	1
AMFR	2	HSPA4	3	affinity chromatography technology	Jo Y (2011)	1
YWHAQ	0	LMNA	2	affinity chromatography technology, pull down	Pozuelo-Rubio M (2010), Meek SE (2004)	2
LMNA	2	FHL1	1	bioid	Roux KJ (2012)	1
CYLD	2	LMNA	2	affinity chromatography technology	Elliott PR (2016)	1
PRNP	4	PIMREG	0	pull down, affinity chromatography technology, affinity chromatography technology	Satoh J (2009), Satoh J (2009), Satoh J (2009)	3
CSNK2A1	15	SRRM2	18	enzymatic study, affinity chromatography technology	Zhang M (2011), So J (2015)	2
PRNP	4	DDX47	0	pull down	Satoh J (2009)	1
CSNK2A1	15	HSPA4	3	enzymatic study	Muller P (2012)	1
AMFR	2	HSPD1	0	affinity chromatography technology	Cao J (2007)	1
PSMA3	1	HSPD1	0	affinity chromatography technology	Fedorova OA (2011)	1
PRNP	4	NHP2	0	pull down	Satoh J (2009)	1
PSMA3	1	WDR5	2	affinity chromatography technology	Fedorova OA (2011)	1
PRNP	4	PYM1	3	pull down	Satoh J (2009)	1
PRNP	4	NOB1	2	pull down	Satoh J (2009)	1
CYLD	2	HSPA5	0	affinity chromatography technology	Elliott PR (2016)	1
PRNP	4	FGF13	0	pull down	Satoh J (2009)	1
CSNK2A1	15	WDR5	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
PRNP	4	CWC15	0	pull down	Satoh J (2009)	1
HSPD1	0	HSPA4	3	biochemical	Wan C (2015)	1
PRNP	4	BAG6	2	two hybrid	Stelzl U (2005)	1
HSPA4	3	RPSA	2	biochemical	Havugimana PC (2012)	1
PRNP	4	MARK4	6	pull down	Satoh J (2009)	1
CYLD	2	PSMD2	2	affinity chromatography technology	Elliott PR (2016)	1
SRRM2	18	PYM1	3	biochemical	Havugimana PC (2012)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
BAG6	2	CLU	1	two hybrid	Wang J (2011)	1
AMFR	2	HSPA5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jo Y (2011), Chang YW (2014), Chang YW (2014), Chang YW (2015), Chang YW (2015)	5
CLU	1	TSC22D4	1	two hybrid	Wang J (2011)	1
CYLD	2	PDE4DIP	10	affinity chromatography technology	Elliott PR (2016)	1
PRNP	4	PABPC4	2	affinity chromatography technology	Wu GR (2017)	1
CLU	1	HSPD1	0	affinity chromatography technology, affinity chromatography technology, pull down	Chaiwatanasirikul KA (2011), Chaiwatanasirikul KA (2011), Chaiwatanasirikul KA (2011)	3
PRNP	4	PPFIBP2	2	pull down	Satoh J (2009)	1
AGO1	11	HSP90AA1	7	affinity chromatography technology	Fabian MR (2009)	1
SRRM2	18	HSPD1	0	affinity chromatography technology	McCracken S (2005)	1
TRIM15	0	PRNP	4	protein complementation assay	Lee OH (2015)	1
LMNA	2	PRNP	4	two hybrid	Dittmer TA (2014)	1
HSPD1	0	HSPA5	0	biochemical	Havugimana PC (2012)	1
CYLD	2	DDX47	0	affinity chromatography technology	Elliott PR (2016)	1
PRNP	4	WDR5	2	pull down	Satoh J (2009)	1
PRNP	4	TBPL1	0	pull down	Satoh J (2009)	1
YWHAQ	0	PABPC4	2	pull down, biochemical	Meek SE (2004), Wan C (2015)	2
PSMA3	1	HSPA5	0	affinity chromatography technology	Fedorova OA (2011)	1
HSP90AA1	7	RPSA	2	affinity chromatography technology	Falsone SF (2005)	1
PRNP	4	UTP4	1	pull down	Satoh J (2009)	1
PRNP	4	494514	0	pull down	Satoh J (2009)	1
CSNK2A1	15	CIRBP	1	enzymatic study	Zhang M (2011)	1
HSP90AA1	7	HSPA5	0	affinity chromatography technology	Gano JJ (2010)	1
PRNP	4	ZNF740	6	pull down	Satoh J (2009)	1
PRNP	4	PSMA3	1	two hybrid	Lim J (2006)	1
CLU	1	HSPA5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang C (2013), Li N (2013), Li N (2013)	3
AGO1	11	CYLD	2	affinity chromatography technology	Zhang L (2015)	1
PAN2	3	HSP90AA1	7	affinity chromatography technology	Bett JS (2013)	1
CYLD	2	PABPC4	2	affinity chromatography technology	Elliott PR (2016)	1
AMFR	2	PSMA3	1	affinity chromatography technology	Christianson JC (2012)	1
PRNP	4	C7orf50	2	pull down	Satoh J (2009)	1
PRNP	4	PDE4DIP	10	pull down	Satoh J (2009)	1
CYLD	2	YWHAQ	0	affinity chromatography technology	Elliott PR (2016)	1
SURF2	0	PABPC4	2	affinity chromatography technology	Huttlin EL (2015)	1
PRNP	4	RPL41	0	pull down	Satoh J (2009)	1
PRNP	4	RPSA	2	affinity chromatography technology, affinity chromatography technology	Wu GR (2017), Lee JH (2017)	2
PAN2	3	PABPC4	2	affinity chromatography technology	Bett JS (2013)	1
PRNP	4	ZFYVE28	7	pull down	Satoh J (2009)	1
PRNP	4	HSPD1	0	affinity chromatography technology	Wu GR (2017)	1
PAN2	3	PABPC1	5	affinity chromatography technology, pull down, affinity chromatography technology	Uchida N (2004), Ezzeddine N (2007), Bett JS (2013)	3
PSMA3	1	STIP1	1	affinity chromatography technology	Fedorova OA (2011)	1
PABPC1	5	RPSA	2	biochemical	Havugimana PC (2012)	1
PSMA3	1	PSMD2	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PRNP	4	PPP1R14A	0	pull down	Satoh J (2009)	1
PRNP	4	PSMD2	2	affinity chromatography technology	Wu GR (2017)	1
PRNP	4	PTRH1	0	pull down	Satoh J (2009)	1
SRRM2	18	LMNA	2	affinity chromatography technology, affinity chromatography technology	McCracken S (2005), Depreux FF (2015)	2
HSPA5	0	SRRM2	18	biochemical	Havugimana PC (2012)	1
PRNP	4	CIRBP	1	pull down	Satoh J (2009)	1
CLU	1	PRNP	4	two hybrid, affinity chromatography technology, pull down	Xu F (2008), Xu F (2008), Xu F (2008)	3
PRNP	4	BAZ2B	15	pull down	Satoh J (2009)	1
STIP1	1	PRNP	4	pull down, affinity chromatography technology	Zanata SM (2002), Zanata SM (2002)	2
PRNP	4	PABPC1	5	affinity chromatography technology	Wu GR (2017)	1
PRNP	4	TSLP	0	pull down	Satoh J (2009)	1
PRNP	4	DYRK3	2	pull down	Satoh J (2009)	1
PRNP	4	TSC22D4	1	two hybrid	Lim J (2006)	1
HSPD1	0	MTG1	2	affinity chromatography technology	Huttlin EL (2017)	1
PRNP	4	ADAP2	3	pull down	Satoh J (2009)	1
PAN2	3	HSPA5	0	affinity chromatography technology	Bett JS (2013)	1
PRNP	4	CCDC149	1	pull down	Satoh J (2009)	1
PRNP	4	ARHGAP15	4	pull down	Satoh J (2009)	1
CYLD	2	HSP90AA1	7	affinity chromatography technology	Elliott PR (2016)	1
PRNP	4	MPG	3	pull down, affinity chromatography technology, affinity chromatography technology	Satoh J (2009), Satoh J (2009), Satoh J (2009)	3
PRNP	4	TMEM237	1	pull down	Satoh J (2009)	1
CYLD	2	PABPC1	5	affinity chromatography technology	Elliott PR (2016)	1
PRNP	4	PLK3	0	pull down, affinity chromatography technology, affinity chromatography technology	Satoh J (2009), Satoh J (2009), Satoh J (2009)	3
PRNP	4	RBM22	0	pull down	Satoh J (2009)	1
PRNP	4	CSNK2A1	15	affinity chromatography technology	Wu GR (2017)	1
ARF1	1	PRNP	4	affinity chromatography technology, affinity chromatography technology	Zafar S (2015), Zafar S (2015)	2
PAN2	3	HSPD1	0	affinity chromatography technology	Bett JS (2013)	1
PRNP	4	ZKSCAN8	0	pull down	Satoh J (2009)	1
PRNP	4	CYLD	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Wu GR (2017), Wu GR (2017), Wu GR (2017)	3
CYLD	2	PSMA3	1	affinity chromatography technology	Elliott PR (2016)	1
HSPA5	0	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
PRNP	4	KIAA1191	0	pull down	Satoh J (2009)	1
PRNP	4	CSN3	1	pull down	Satoh J (2009)	1
PRNP	4	AGO1	11	pull down	Satoh J (2009)	1
HSPA5	0	RPSA	2	biochemical	Havugimana PC (2012)	1
PSMA3	1	HSP90AA1	7	affinity chromatography technology	Fedorova OA (2011)	1
AGO1	11	PABPC1	5	affinity chromatography technology	Fabian MR (2009)	1
LMNA	2	CSNK2A1	15	affinity chromatography technology	Depreux FF (2015)	1
CYLD	2	WDR5	2	affinity chromatography technology	Elliott PR (2016)	1
PRNP	4	AIFM3	6	pull down	Satoh J (2009)	1
AMFR	2	BAG6	2	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Wang Q (2011), Wang Q (2011), Xu Y (2012), Xu Y (2012), Xu Y (2012), Wang Q (2011), Liu Y (2014), Zhang T (2015)	9
PRNP	4	ZNF408	0	pull down	Satoh J (2009)	1
PDE4DIP	10	ZNF408	0	two hybrid	Rolland T (2014)	1
PRNP	4	SCNM1	0	pull down	Satoh J (2009)	1
PRNP	4	HOXA1	4	pull down, affinity chromatography technology, affinity chromatography technology	Satoh J (2009), Satoh J (2009), Satoh J (2009)	3
STIP1	1	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Scheufler C (2000), Johnson BD (1998), Mollapour M (2010), Li J (2011), Kundrat L (2010), Tsutsumi S (2012), Sarkar S (2012), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Brinker A (2002), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Graumann K (2000), Hein MY (2015), Chadli A (2010), Chadli A (2008), Woodford MR (2016), Scholz GM (2001), Sun L (2012), Woodford MR (2016), Huttlin EL (2017)	23
PRNP	4	FHL1	1	pull down	Satoh J (2009)	1
PRNP	4	IER3	0	pull down	Satoh J (2009)	1
HSPA4	3	PRNP	4	affinity chromatography technology	Wang GH (2011)	1
STIP1	1	HSPA4	3	affinity chromatography technology, pull down, pull down, pull down, biochemical	Johnson BD (1998), Horibe T (2011), Brinker A (2002), Graumann K (2000), Wan C (2015)	5
PDE4DIP	10	SCNM1	0	two hybrid	Rolland T (2014)	1
PRNP	4	ABT1	0	pull down	Satoh J (2009)	1
CSNK2A1	15	PSMA3	1	enzymatic study	Zhang M (2011)	1
CYLD	2	HSPD1	0	affinity chromatography technology	Elliott PR (2016)	1
HSP90AA1	7	CSNK2A1	15	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Miyata Y (1995), Muller P (2012), Zhang M (2011), Woo SH (2009)	4
LMNA	2	NHP2	0	affinity chromatography technology	Depreux FF (2015)	1
PRNP	4	MTG1	2	pull down	Satoh J (2009)	1
PAN2	3	SRRM2	18	affinity chromatography technology	Bett JS (2013)	1
MARK4	6	HSPA4	3	affinity chromatography technology	Trinczek B (2004)	1
PRNP	4	SURF2	0	pull down	Satoh J (2009)	1
PAN2	3	PRNP	4	affinity chromatography technology	Bett JS (2013)	1
FHL1	1	PDE4DIP	10	two hybrid	Vinayagam A (2011)	1
CYLD	2	C7orf50	2	affinity chromatography technology	Elliott PR (2016)	1
PRNP	4	YWHAQ	0	affinity chromatography technology	Wu GR (2017)	1